nTRD22
Based on 1 Customer Validation
nTRD22 is an RNA-binding allosteric modulator targeting TDP-43. nTRD22 binds to the N-terminal domain of TDP-43, thereby allosterically regulating the RNA-binding domain of TDP-43 and reducing its RNA-binding ability. nTRD22 decreases the TDP-43 protein level in primary motor neurons. nTRD22 alleviates motor dysfunction in amyotrophic lateral sclerosis models. nTRD22 is applicable to related research on amyotrophic lateral sclerosis.
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- 純度 : 95.0%
- CAS 番号: 1065567-62-5
- 分子式: C19H22F3N3O4
- 分子量:413.39
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
nTRD22 (0.03 μM-1 mM) binds to full-length TDP-431-260 with an apparent Kd of 145 ± 3 μM and to the isolated N-terminal domain TDP-431-102 with an apparent Kd of 96 ± 36 μM[1].
nTRD22 inhibits TDP-431-260 binding to UG6 RNA with an IC50 of ~100 μM in an alpha assay[1].
nTRD22 (0.1-500 μM) inhibits TDP-431-260 binding to (UG)6 RNA with an IC50 of ~145 μM and achieves ~30% inhibition of the interaction in an SPR assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:GAL4-UAS bipartite expression system line (overexpressing human TDP-43 in motor neurons)[1]
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Dosage:50 μM
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Administration:incorporated into fly food; continuous exposure
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Result:Significantly improved motor performance, with a greater percentage of flies crossing the target climbing line over the 2-minute assay period compared to control groups.
Showed increased rescue effect in aged flies.
化学情報
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CAS 番号 1065567-62-5
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性状 Solid
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分子量 413.39
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分子式 C19H22F3N3O4
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Color White to light yellow
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SMILES
O=C(C1=NOC(COC2=CC=CC(C(F)(F)F)=C2)=C1)NCCN3CCCC(C3)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (268 KB)
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- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
nTRD22 関連分類
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