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製品番号: HY-125279

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OAT-2068

OAT-2068 is a selective, high activity and orally active inhibitor of mouse chitotriosidase (mCHIT1) (IC₅₀=29 nM) and displays 143-fold selectivity over m AMCase (IC₅₀=4170 nM). OAT-2068 displays a good pharmacokinetic profile and is an ideal tool to study the role of CHIT1 in biological systems, including animal models of human diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2221950-65-6
分子式: C₂₃H₃₆ClN₇
分子量:446.03

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

OAT-2068 構造式

CAS 番号: 2221950-65-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

IC50: 29 nM (mCHIT1); 4200 nM (mAMCase)
IC50: 67 nM (hCHIT1); 1300 nM (hAMCase)^[2]

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

OAT-2068 is a potent inhibitor developed for mAMCase (IC₅₀=4200 nM) and mCHIT1(IC₅₀=29 nM), which also displays activity toward hAMCase (IC₅₀=67 nM) and hCHIT1 (IC₅₀=1300 nM), it exhibits off-target activity toward the human ether-a-go-go-related gene (hERG)(hERG IC₅₀=2.4 μM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

OAT-2068 (intravenous injection; 3 mg/kg; single dose) displays a favorable pharmacokinetic profile, showing moderate plasma clearance (1.71 mg*kg/L),good volume of distribution (4.6 L/h/kg), and T_1/2 (2.87 h) in female BALB/c mice^[1].
OAT-2068 (oral administartion; 10 mg/kg; single dose) displays a favorable pharmacokinetic profile,it is rapidly absorbed with T_max 0.5 h and exhibited a high bioavailability of 61%, the T_1/2 and the plasma clearance are 2.83 hours and 3.57 mg*kg/L, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2221950-65-6
分子量 446.03
分子式 C₂₃H₃₆ClN₇
SMILES

NC1=NNC(N2CCC(N3[C@@H](CC4=CC=C(Cl)C=C4)CN(CC(C)C)[C@@H](C)C3)CC2)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Marzena Mazur, et al. Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase. Bioorg Med Chem Lett. 2018 Feb 1;28(3):310-314. [Content Brief]

[2]. Gleb Andryianau, et al. Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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