PF-03049423
PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 402955-58-2
- 分子式: C24H32N6O4.xHCl
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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PDE5A |
rat and human platelet enzyme ~0.2 nM (IC50) |
PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model[1]
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Dosage:0.1, 1, or 10 mg/kg
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Administration:Subcutaneous injection, b.i.d. for 7 days
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Result:Improved functional recovery at 1 mg/kg and 10 mg/kg.
化学情報
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CAS 番号 402955-58-2
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分子式 C24H32N6O4.xHCl
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SMILES
O=C1C(N2CCN(CC2)CCO)=NC3=C(N1CCOCCC)C=C(C4=CC=C(OC)N=C4)N=C3.[x HCl]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PF-03049423 関連分類
HY-10679A 関連分類
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