PHPS1
Based on 6 publication(s) in Google Scholar
PHPS1 is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.99%
- CAS 番号: 314291-83-3
- 分子式: C21H15N5O6S
- 分子量:465.44
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Kinase Inhibitor Library
HY-L009
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Metabolism/Protease Compound Library
HY-L012
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cardiovascular Disease Compound Library
HY-L046
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Phosphatase Inhibitor Library
HY-L081
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Anti-Obesity Compound Library
HY-L087
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Metabolic Enzyme Compound Library
HY-L146
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Highly Selective Inhibitors Library
HY-L158
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
MedChemExpress（MCE）の使用を引用している文献 PHPS1
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生物活性
Ki: 0.73 μM (Shp2), 5.8 μM (Shp2-R362K), 10.7 μM (Shp1), 5.8 μM (PTP1B), 0.47 μM (PTP1B-Q)[1]
PHPS1 (30 μM; 6 days) inhibits proliferation of human tumor cells[1].
PHPS1 (5-20 μM; 5-360 minutes) inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human cancer cell lines MDA-MB-435, HCT-116 (colon carcinoma), HCT-15 (colon carcinoma), PC-3 (prostate carcinoma) HT-29 (colon carcinoma), NCI-H661 (lung carcinoma), and Caki-1 (kidney carcinoma)
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Concentration:30 μM
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Incubation Time:6 days
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Result:Resulted in a reduction in cell number of between 0% (Caki-1) to 74% (HT-29).
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Cell Line:Madin-Darby canine kidney (MDCK) cells
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Concentration:5, 10, 20 μM
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Incubation Time:5, 15, 60, 120, 360 minutes
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Result:Inhibited HGF/SF (1 unit/mL)-induced phosphorylation and thus activation of Erk1/2 over a time period of 15 min to 6 h. In contrast, transient phosphorylation of Erk1/2 after 5 min was not affected.
Exhibited no effect on HGF/SF-induced activation of PI3K/Akt or Stat3.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ldlr-/- (005061) mice[2]
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Dosage:3 mg/kg
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Administration:Intraperitoneal (i.p.) injection; every day during the last week on the high-fat diet.
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Result:Revealed a significant decrease in atherosclerotic plaque size in the aorta compared with the other two groups.
化学情報
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CAS 番号 314291-83-3
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性状 Solid
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分子量 465.44
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分子式 C21H15N5O6S
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Color Red to reddish brown
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SMILES
O=S(C1=CC=C(N/N=C2C(C3=CC=C([N+]([O-])=O)C=C3)=NN(C4=CC=CC=C4)C\2=O)C=C1)(O)=O
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別名
PTP Inhibitor V, PHPS1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Sci Rep
SHP2 improves ovarian morphology and steroidogenic function in a rat PCOS model by modulating IRE1α/XBP1/NLRP3-mediated granulosa cell pyroptosis. [Abstract]2026 Mar 21;16(1):14376. PMID: 41865134 -
Sci Rep
CBX2 promoted oral squamous cell carcinoma via increasing CEP55/NF-κB/METTL3/SHP2 signaling induced metastasis/proliferation and angiogenesis. [Abstract]2025 Dec 21. PMID: 41423460 -
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Biol Reprod
SHP2 regulates the HIF-1 signaling pathway in the decidual human endometrial stromal cells. [Abstract]2025 Apr 13;112(4):743-753. PMID: 39893623 -
Biomol Biomed
Nogo-A exacerbates sepsis-associated encephalopathy by modulating microglial SHP-2/NLRP3 balance and inducing ROS and M1 polarization. [Abstract]2024 Dec 11;25(1):210-225. PMID: 39151100 -
Heliyon
Decorin impeded the advancement of thyroid papillary carcinoma by thwarting the EGFR/ FER/ SHP2 signaling-induced sustenance of early endosomes. [Abstract]2024 Jun 20;10(13):e33358. PMID: 39035505
溶剤 & 溶解度
DMSO : 25 mg/mL (53.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (283 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Klaus Hellmuth, et al. Specific Inhibitors of the Protein Tyrosine Phosphatase Shp2 Identified by High-Throughput Docking. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7275-80. [Content Brief]
[2]. Jia Chen, et al. SHP2 Inhibitor PHPS1 Protects Against Atherosclerosis by Inhibiting Smooth Muscle Cell Proliferation. BMC Cardiovasc Disord. 2018 Apr 27;18(1):72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1485 mL | 10.7425 mL | 21.4850 mL | 53.7126 mL |
| 5 mM | 0.4297 mL | 2.1485 mL | 4.2970 mL | 10.7425 mL | |
| 10 mM | 0.2149 mL | 1.0743 mL | 2.1485 mL | 5.3713 mL | |
| 15 mM | 0.1432 mL | 0.7162 mL | 1.4323 mL | 3.5808 mL | |
| 20 mM | 0.1074 mL | 0.5371 mL | 1.0743 mL | 2.6856 mL | |
| 25 mM | 0.0859 mL | 0.4297 mL | 0.8594 mL | 2.1485 mL | |
| 30 mM | 0.0716 mL | 0.3581 mL | 0.7162 mL | 1.7904 mL | |
| 40 mM | 0.0537 mL | 0.2686 mL | 0.5371 mL | 1.3428 mL | |
| 50 mM | 0.0430 mL | 0.2149 mL | 0.4297 mL | 1.0743 mL |
PHPS1 関連分類
HY-112368 関連分類
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