PQ32
PQ32 is an antitumor agent that targets c-MYC Pu27 and KRAS G-quadruplexes. PQ32 inhibits tumor cell proliferation, arrests the cell cycle at the G2 phase, and induces apoptosis. PQ32 inhibits the expression of c-MYC and KRAS genes. PQ32 can inhibit tumor growth in mice and is used in the study of lymphoma, breast cancer, lung cancer, hepatocellular carcinoma, colorectal cancer, and other cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C27H21N3O6
- 分子量:483.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
K-RAS |
体外実験
PQ32 shows anti-tumor activity against RAJI, CA46, MDA-MB-231, A549, HepG2, HT29, HEK-293T cells, with IC50s of 1.75, 2.68, 1.07, 3.48, 2.72, 1.50, 4.09 μM, respectively[1].
PQ32 (1.5 μM, 24 h) induces cell cycle arrest and apoptosis in MDA-MB-231 cells[1].
PQ32 (1.5-3 μM, 24-72 h) inhibits c-MYC and KRAS gene and protein expression in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:1.5 μM
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Incubation Time:24 h
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Result:Arrested the cells in the G2 phase (increasing from 4.01% to 27.01%).
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Cell Line:MDA-MB-231
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Concentration:1.5 μM
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Incubation Time:24 h
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Result:Induced cell apoptosis (46.84%).
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Cell Line:MDA-MB-231
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Concentration:1.5 μM, 3 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Inhibited c-MYC and KRAS gene expression.
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Cell Line:MDA-MB-231
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Concentration:1.5 μM, 3 μM
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Incubation Time:24 h, 48 h, 72 h
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Result:Inhibited c-MYC and KRAS protein expression.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HT29 cancer xenografts (5 × 106 cells, s.c.) female nude mice (BALB/c, 4-weeks old, 14-17 g) [1]
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Dosage:15 mg/kg
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Administration:intratumoral injection, every other day, 21 days
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Result:Resulted in a significant reduction in tumor weight with tumor growth inhibition of 59%, displayed time-dependent inhibition of tumor growth.
化学情報
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分子量 483.47
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分子式 C27H21N3O6
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SMILES
COC(C=CC(CN1C=C2C(C3=CC4=C(C=C3)OCO4)=NN=C2C5=C1C=C6OCOC6=C5)=C7)=C7OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PQ32 関連分類
HY-175265 関連分類
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