製品番号: HY-W404916

Probenecid sodium

49 Cited Publications

カスタマーレビュー

Based on 49 publication(s) in Google Scholar

Probenecid sodium is an orally active, blood-brain barrier-permeable Pannexin 1 channel inhibitor. Probenecid sodium exhibits anti-inflammatory, antiviral, and neuroprotective activities. Probenecid sodium can be used in research related to multiple sclerosis, focal cerebral ischemic injury, influenza virus infection, and nephropathy.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.37%
CAS 番号: 23795-03-1
分子式: C₁₃H₁₈NNaO₄S
分子量:307.34

保管条件:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Probenecid sodium 構造式

CAS 番号: 23795-03-1

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (49)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

TRPV2

Interleukin Related アイソフォーム固有の製品をすべて表示 :

体外実験

Probenecid (0.001-100000 μM; 1-24 h) sodium potently inhibits the replication of Anhui/1-H7N9 in NHBE/A549 cells^[1].
Probenecid (0.001-100000 μM; 1-24 h) sodium potently inhibits the replication of VN/1203-H5N1 in VeroE6 cells, with an IC₅₀ of 0.00003 μM under the condition of 24 h prophylactic treatment and an IC₅₀ of 0.001 μM under the condition of treatment at 1 hour post-infection^[1].
Probenecid sodium inhibits the entry of aristolochic acid into proximal tubular cell lines via human organic anion transporters (OATs) and preserves cell viability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Probenecid (10-100 mg/kg; oral gavage; twice daily for 3 consecutive days) sodium reduces H5N1 influenza-induced body weight loss, decreases pulmonary viral titers, and lowers pro-inflammatory cytokine levels^[1].
Probenecid (150 mg/kg; i.p.; twice daily; up to 8 days) sodium exerts renoprotective effects in a mouse model of aristolochic acid nephropathy, prevents acute kidney injury, alleviates tubulointerstitial injury and DNA repair/proliferation responses, and reduces the levels of advanced aristolochic acid-DNA adducts^[2].
Probenecid (250 mg/kg, i.p., once daily for 20 consecutive days) sodium inhibits symptom progression in mice with autoimmune encephalomyelitis^[3].
Probenecid (1 mg/kg; intraperitoneal injection; twice) sodium significantly reduces cerebral infarction volume and improves neurological function in a mouse model of focal cerebral ischemia^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice (female, 6-8 weeks old)^[1]
Dosage:

10 mg/kg; 100 mg/kg
Administration:

i.g.; twice daily; 3 days
Result:

Maintained stable weight from day 3 pi through day 6 pi.
Reduced lung virus titers (10 mg/kg).
Eliminated detectable lung virus(100 mg/kg).
Caused a significant reduction in serum IL-6, TNF-α, and IL-1β levels on days 3 and 5 pi compared to untreated infected controls (10 mg/kg and 100 mg/kg).

Animal Model:

C57BL/6 mice (12-week-old, experimental autoimmune encephalomyelitis model)^[3]
Dosage:

250 mg/kg
Administration:

i.p.; once daily; 20 days
Result:

Stabilized clinical scores on day 16 post-immunization and maintained unchanged scores for the duration of the experiment, with a significantly lower mean clinical score at day 28 compared to control groups.
Achieved 89% survival rate (8 out of 9 mice) by day 35 post-immunization, compared to 50% in untreated EAE mice and less than 65% in solvent-treated mice.
Reduced CD3-positive T cell numbers in spinal cords compared to control groups.
Decreased CD68-positive activated microglia area in spinal cords compared to control groups.
Increased Olig-2-positive oligodendrocyte numbers significantly in spinal cords compared to control groups.
Elevated myelinated area (via PAS staining) significantly in spinal cords compared to control groups.

Animal Model:

C57BL/6J mice (male, 25-30 g, focal cerebral ischemia induced by middle cerebral artery occlusion for 60 minutes followed by reperfusion)^[4]
Dosage:

1 mg/kg
Administration:

i.p.; injected immediately before ischemia onset and 2 hours after reperfusion; injected immediately after reperfusion and 3 hours after reperfusion
Result:

Reduced infarct volume and improved neurological score.
Attenuated stroke-induced increases in ipsilateral cortical brain water content.
Significantly increased the number of NeuN+ neurons in the ischemic core.
Significantly reduced the number of CD68+ macrophages/microglia in the ischemic core.
Significantly reduced serum HMGB1 concentrations.
Downregulated AQP4 protein expression in the cortical penumbra.
Reduced activation of GFAP+ astrocytes in the cortical penumbra.

化学情報

CAS 番号 23795-03-1
性状 Solid
分子量 307.34
分子式 C₁₃H₁₈NNaO₄S
Color White to off-white
SMILES

O=C(C1=CC=C(S(=O)(N(CCC)CCC)=O)C=C1)O[Na]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (49)

All

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Journal Impact Factor

Cell Res

SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors. [Abstract]

2022 Jul;32(7):638-658. PMID: 35459936
Immunity

Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine. [Abstract]

2022 Apr 12;55(4):686-700.e7. PMID: 35320705
Nat Immunol

Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infection. [Abstract]

2026 May;27(5):949-960. PMID: 41781710
Cell Mol Immunol

ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome. [Abstract]

2020 Mar;17(3):261-271. PMID: 30911117
Nat Commun

ERα blockade in dendritic cells enhances antigen cross-presentation and induces antitumor CD8+ T cell immunity. [Abstract]

2026 May 5;17(1):6063. PMID: 42086580
Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
Adv Sci (Weinh)

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2-Mediated Cytoskeletal-Nuclear Mechanotransduction. [Abstract]

2025 Dec 22:e09056. PMID: 41431162
Adv Sci (Weinh)

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease. [Abstract]

2025 Oct 6:e10270. PMID: 41051385
Adv Sci (Weinh)

Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease. [Abstract]

2025 Jul;12(28):e2503579. PMID: 40344619
Cell Death Differ

GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration. [Abstract]

2026 Mar 31. PMID: 41917182
Int J Biol Sci

GRP75-faciliated Mitochondria-associated ER Membrane (MAM) Integrity controls Cisplatin-resistance in Ovarian Cancer Patients. [Abstract]

2022 Apr 11;18(7):2914-2931. PMID: 35541901
Acta Pharmacol Sin

Species differences in the hepatobiliary disposition of morphine-6-glucuronide mediated by hepatic transporters in rats and humans. [Abstract]

2025 Sep 15. PMID: 40954191
J Transl Med

Chronic sleep deprivation induces plasma exosome-derived miR-150-5p downregulation as a novel mechanism involved in Parkinson's disease progression by targeting DCLK1. [Abstract]

2025 Jul 11;23(1):781. PMID: 40646516
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Food Res Int

Ergothioneine exerts neuroprotective effects in Parkinson's disease: Targeting α-synuclein aggregation and oxidative stress. [Abstract]

2025 Feb:201:115590. PMID: 39849723
Drug Deliv

Reliable high-PAP-1-loaded polymeric micelles for cancer therapy: preparation, characterization, and evaluation of anti-tumor efficacy. [Abstract]

2025 Dec;32(1):2490269. PMID: 40207975
Cell Rep

Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib. [Abstract]

2025 Mar 25;44(4):115466. PMID: 40138312
Chin Med

Targeting G-protein-coupled receptors and gut microbiota: Ge-Lian Qi-Shen decoction elevates GLP-1 to combat non-alcoholic fatty liver disease. [Abstract]

2026 Jan 24;21(1):51. PMID: 41580820
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Front Immunol

TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarization. [Abstract]

2026 Jan 12:16:1683500. PMID: 41624842
Redox Rep

Uric acid alleviates the inflammatory response in LPS-induced BV2 cells and MPTP-induced PD mice by resisting ferroptosis through the Nrf2 signalling pathway. [Abstract]

2026 Dec 31;31(1):2668238. PMID: 42241031
J Agric Food Chem

Nuciferine Alleviates Renal Injury by Inhibiting Inflammatory Responses in Fructose-Fed Rats. [Abstract]

2016 Oct 26;64(42):7899-7910. PMID: 27718563
Biochem Pharmacol

Aquaporin-1 (AQP1) mediates cardiac oedema and mitochondrial dysfunction in cardiometabolic HFpEF: New insights into the mechanisms of SGLT2 inhibitors. [Abstract]

2026 Jun 12;251(Pt 2):118159. PMID: 42285370
Transl Res

Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway. [Abstract]

2024 May 9:271:26-39. PMID: 38734063
Pharmaceuticals (Basel)

Neuroprotective Effects of Rosa roxburghii Tratt Juice Concentrate Powder in Parkinson's Disease Mice via the PI3K/AKT Signaling Pathway. [Abstract]

2026 May;19(5):711. PMID: 42198384
Int J Mol Sci

Cisplatin Synergistically Enhances Antitumor Potency of Conditionally Replicating Adenovirus via p53 Dependent or Independent Pathways in Human Lung Carcinoma. [Abstract]

2019 Mar 5;20(5):1125. PMID: 30841620
Front Pharmacol

Ca2+-Permeable Channels/Ca2+ Signaling in the Regulation of Ileal Na+/Gln Co-Transport in Mice. [Abstract]

2022 Feb 23;13:816133. PMID: 35281933
Chem Biol Interact

7-Hydroxycoumarin and its conjugated metabolites interact with organic anion transporters 1 and 3 in vitro and in vivo. [Abstract]

2025 Jan 5:405:111293. PMID: 39481674
Cell Calcium

Impact of channel properties, imaging strategies and diffusional constraints on the detectability of Ca2+ microdomains. [Abstract]

2026 Mar 20:135:103133. PMID: 41895149
Cell Calcium

Simultaneous TIRF imaging of subplasmalemmal Ca2+ dynamics and granule fusions in insulin-secreting INS-1 cells reveals coexistent synchronized and asynchronous release. [Abstract]

2024 Jun:120:102883. PMID: 38643716
Exp Neurol

Early α-synuclein/synapsin III co-accumulation, nigrostriatal dopaminergic synaptopathy and denervation in the MPTPp mouse model of Parkinson's Disease. [Abstract]

2025 Jan:383:115040. PMID: 39500391
Regul Toxicol Pharmacol

Characterization of in vitro Mrp2 transporter model based on intestinal organoids. [Abstract]

2019 Nov:108:104449. PMID: 31449916
J Endocrinol Invest

Pannexin-1 regulation of ATP release promotes the invasion of pituitary adenoma. [Abstract]

2025 Feb;48(2):317-332. PMID: 39527372
Toxicol Appl Pharmacol

Human trophoblast organoids for improved prediction of placental ABC transporter-mediated drug transport. [Abstract]

2024 Nov:492:117112. PMID: 39326791
Neuroscience

Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK/AKT Signaling Pathway. [Abstract]

2022 Jul 1:494:51-68. PMID: 35158017
Mol Pharmacol

Transient receptor potential vanilloid 3 activation accelerates keratinocyte migration in vitro but not dermal wound healing in vivo. [Abstract]

2025 Dec;107(12):100084. PMID: 41240425
J Dig Dis

DREADDs-Based Chemogenetics Induced Slow Transit Constipation via Inhibition of Enteric Neurons. [Abstract]

2025 Apr 14. PMID: 40223443
Toxicol In Vitro

YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells. [Abstract]

2020 Dec:69:104971. PMID: 32805372
Adv Med Educ Pract

Online Medical Education in India - Different Challenges and Probable Solutions in the Age of COVID-19. [Abstract]

2021 Mar 4:12:237-243. PMID: 33692645
Biochem Biophys Res Commun

Protective role of TRPV2 in synaptic plasticity through the ERK1/2-CREB-BDNF pathway in chronic unpredictable mild stress rats. [Abstract]

2024 Aug 20:721:150128. PMID: 38776831
Biopharm Drug Dispos

Inhibition of canalicular and sinusoidal taurocholate efflux by cholestatic drugs in human hepatoma HepaRG cells. [Abstract]

2022 Dec;43(6):265-271. PMID: 36195987
Lasers Surg Med

The sensitivity of glioma cells to pyropheophorbide-αmethyl ester-mediated photodynamic therapy is enhanced by inhibiting ABCG2. [Abstract]

2017 Sep;49(7):719-726. PMID: 28370217
Cutan Ocul Toxicol

Leveraging a TRPV1-overexpressing cell model: an integrated testing strategy for UV filter-induced ocular irritation. [Abstract]

2026 Jun;45(2):243-250. PMID: 41985167
bioRxiv

2026 Mar 12.
bioRxiv

2026 Jan 7.
bioRxiv

2025 Dec 18.
Res Sq

2024 Nov 17.
Research Square Print

August 31st, 2022.
Research Square Preprint

2021 Aug.

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (325.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2537 mL

16.2686 mL

32.5373 mL

5 mM

0.6507 mL

3.2537 mL

6.5075 mL

10 mM

0.3254 mL

1.6269 mL

3.2537 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

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参考文献

[1]. Murray J, et al. Probenecid Inhibits Influenza A(H5N1) and A(H7N9) Viruses In Vitro and in Mice. Viruses. 2024;16(1):152. Published 2024 Jan 19. [Content Brief]

[2]. Baudoux TE, et al. Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy. Kidney Int. 2012;82(10):1105-1113. [Content Brief]

[3]. Hainz N, et al. Probenecid arrests the progression of pronounced clinical symptoms in a mouse model of multiple sclerosis. Sci Rep. 2017;7(1):17214. Published 2017 Dec 8. [Content Brief]

[4]. Xiong XX, et al. Probenecid protects against transient focal cerebral ischemic injury by inhibiting HMGB1 release and attenuating AQP4 expression in mice. Neurochem Res. 2014;39(1):216-224. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2537 mL	16.2686 mL	32.5373 mL	81.3431 mL
	5 mM	0.6507 mL	3.2537 mL	6.5075 mL	16.2686 mL
	10 mM	0.3254 mL	1.6269 mL	3.2537 mL	8.1343 mL
	15 mM	0.2169 mL	1.0846 mL	2.1692 mL	5.4229 mL
	20 mM	0.1627 mL	0.8134 mL	1.6269 mL	4.0672 mL
	25 mM	0.1301 mL	0.6507 mL	1.3015 mL	3.2537 mL
	30 mM	0.1085 mL	0.5423 mL	1.0846 mL	2.7114 mL
	40 mM	0.0813 mL	0.4067 mL	0.8134 mL	2.0336 mL
	50 mM	0.0651 mL	0.3254 mL	0.6507 mL	1.6269 mL
	60 mM	0.0542 mL	0.2711 mL	0.5423 mL	1.3557 mL
	80 mM	0.0407 mL	0.2034 mL	0.4067 mL	1.0168 mL
	100 mM	0.0325 mL	0.1627 mL	0.3254 mL	0.8134 mL

Keywords

Probenecid sodium

49 Cited Publications

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Probenecid sodium

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Antiviral Compound Library

CNS-Penetrant Compound Library

Anti-Cardiovascular Disease Compound Library

Orally Active Compound Library

Neuroprotective Compound Library

Angiogenesis-Related Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

MedChemExpress（MCE）の使用を引用している文献 Probenecid sodium

Interleukin Related アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (49)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Probenecid sodium

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Antiviral Compound Library

CNS-Penetrant Compound Library

Anti-Cardiovascular Disease Compound Library

Orally Active Compound Library

Neuroprotective Compound Library

Angiogenesis-Related Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

MedChemExpress（MCE）の使用を引用している文献 Probenecid sodium

Interleukin Related アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (49)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Probenecid sodium 関連分類

HY-W404916 関連分類