ProINDY
Based on 1 Customer Validation
ProINDY, a prodrug of INDY (HY-108476), is a DYRK1A and DYRK1B inhibitor. ProINDY effectively recovers Xenopus embryos from head malformation induced by Dyrk1A overexpression.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.55%
- CAS 番号: 719277-30-2
- 分子式: C14H15NO3S
- 分子量:277.34
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-108476
INDY
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HY-A0063
Tipiracil hydrochloride
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HY-102071
KIN59
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HY-108476R
INDY (Standard)
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HY-100464
tBID
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HY-115677
ILK-IN-3
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HY-34222
7-Deazaguanine
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HY-A0063R
Tipiracil hydrochloride (Standard)
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HY-102071R
KIN59 (Standard)
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HY-13455A
LDN-192960 hydrochloride
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HY-142295A
GNF2133 hydrochloride
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HY-100464R
tBID (Standard)
生物活性
In the cultured cells overexpressing Dyrk1A or xDyrk1A, ProINDY inhibits the phosphorylation of Thr212 of the tau-protein. ProINDY also rescues the NFAT pathway in Dyrk1A-overexpressing cells, confirming the identical Dyrk1A-inhibitory effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 719277-30-2
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性状 Solid
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分子量 277.34
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分子式 C14H15NO3S
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Color Off-white to light yellow
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SMILES
CC(/C=C1SC2=CC=C(OC(C)=O)C=C2N\1CC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (360.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6057 mL | 18.0284 mL | 36.0568 mL | 90.1421 mL |
| 5 mM | 0.7211 mL | 3.6057 mL | 7.2114 mL | 18.0284 mL | |
| 10 mM | 0.3606 mL | 1.8028 mL | 3.6057 mL | 9.0142 mL | |
| 15 mM | 0.2404 mL | 1.2019 mL | 2.4038 mL | 6.0095 mL | |
| 20 mM | 0.1803 mL | 0.9014 mL | 1.8028 mL | 4.5071 mL | |
| 25 mM | 0.1442 mL | 0.7211 mL | 1.4423 mL | 3.6057 mL | |
| 30 mM | 0.1202 mL | 0.6009 mL | 1.2019 mL | 3.0047 mL | |
| 40 mM | 0.0901 mL | 0.4507 mL | 0.9014 mL | 2.2536 mL | |
| 50 mM | 0.0721 mL | 0.3606 mL | 0.7211 mL | 1.8028 mL | |
| 60 mM | 0.0601 mL | 0.3005 mL | 0.6009 mL | 1.5024 mL | |
| 80 mM | 0.0451 mL | 0.2254 mL | 0.4507 mL | 1.1268 mL | |
| 100 mM | 0.0361 mL | 0.1803 mL | 0.3606 mL | 0.9014 mL |
ProINDY 関連分類
HY-108475 関連分類
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