PD-1
null Programmed cell death protein 1 (PD-1, CD279) is an inhibitory receptor of the CD28 superfamily induced on activated, exhausted and antigen-experienced T cells, B cells, NK cells and myeloid cells. PD-1 engages two ligands, PD-L1 (B7-H1/CD274), inducibly expressed on hematopoietic and parenchymal cells, and PD-L2 (B7-DC/CD273), restricted to dendritic cells and macrophages. Ligand binding phosphorylates the PD-1 cytoplasmic ITIM and ITSM motifs, recruiting SHP-2 phosphatase that attenuates TCR and CD28 proximal signaling, blunting proliferation, cytokine output, cytotoxicity and survival. This pathway physiologically limits autoimmunity and tissue damage during chronic antigen exposure, but is co-opted by tumors and chronic infections to sustain T-cell exhaustion. PD-1 blockade with pembrolizumab, nivolumab, cemiplimab and related antibodies has revolutionized oncology across dozens of cancer types; PD-1 is also implicated in primary biliary cholangitis and lupus autoimmunity.
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PD-1 組換えタンパク質 (36)
PD-1 Protein, Human (HEK293, His)
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製品番号: HY-P7396
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (CHO, Fc)
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製品番号: HY-P7395
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (HEK293, mFc)
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製品番号: HY-P70525
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (Biotinylated, HEK293, His-Avi)
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製品番号: HY-P72406
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (Biotinylated, HEK293, Fc-Avi)
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製品番号: HY-P78191
純度: ≥ 95%, as determined by Bis-Tris PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (147a.a, HEK293, His)
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製品番号: HY-P70766
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (HEK293, hFc)
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製品番号: HY-P73344A
純度: ≥ 95%, as determined by reducing SDS-PAGE.;≥ 90%, as determined by HPLC.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (C93S, HEK293, His)
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製品番号: HY-P70799
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Mouse (HEK293, His-Fc)
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製品番号: HY-P73724
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (HEK293, His-Fc)
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製品番号: HY-P73345
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Canine (HEK293, Fc)
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製品番号: HY-P73341
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Human (Biotinylated, HEK293, His)
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製品番号: HY-P77509
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Rat (HEK293, His)
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製品番号: HY-P73347
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Rhesus Macaque (HEK293, His)
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製品番号: HY-P73350
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Mouse (HEK293, His)
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製品番号: HY-P70640
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Mouse (HEK293, Fc)
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製品番号: HY-P70639
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Cynomolgus (HEK293, His)
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製品番号: HY-P70676
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Canine (HEK293, His, solution)
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製品番号: HY-P73342
純度: ≥ 90%, as determined by reducing SDS-PAGE.;≥ 95%, as determined by HPLC.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Canine (Biotinylated, HEK293, His-Avi)
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製品番号: HY-P73727
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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PD-1 Protein, Rabbit (HEK293, His)
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製品番号: HY-P78605
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: PDCD1; Systemic Lupus Erythematosus Susceptibility 2; Prev. SLEB2; HPD-1; PD1; Programmed Cell Death 1 Protein; Programmed Cell Death Protein 1; CD279 Antigen; CD279; ADMIO4; HSLE1; AIMTBS; PD-1; HPD-L; Programmed Cell Death 1; Protein PD-1
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
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Capetin (28-54), human
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- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
