製品番号: HY-N4150

Quercetagitrin

(別名: Quercetagetin-7-O-glucoside)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta). Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC₅₀ = 1 μM) and PTPN9 (IC₅₀ = 1.7 μM). Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimer’s disease and type 2 diabetes.

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純度: 98.33%
CAS 番号: 548-75-4
分子式: C₂₁H₂₀O₁₃
分子量:480.38

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Quercetagitrin 構造式

CAS 番号: 548-75-4

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Sample (0.1mg)

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Use of MCE Products

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生物活性

製品説明

NF-κB アイソフォーム固有の製品をすべて表示 :

体外実験

Quercetagitrin (3.12-100 μM, 0-48 h) decreases the peak flurorescence and inhibits tau-K18 aggregation in a dose-dependent manner^[3].
Quercetagitrin (10-40 μM, 24 h) decreases tau phosphorylation levels and total tau levels concentration-dependently in HEK293 cells transfected with human 1N4R P301S-tau plasmids sup>[3].
Quercetagitrin (10-20 μM, 24 h) decreases tau phosphorylation levels and total tau levels concentration-dependently in N2a cells transfected with human 1N4R P301S-tau plasmids sup>[3].
Quercetagitrin (Compound QG) inhibits PTPN6 (IC₅₀ = 1 μM) and PTPN9 (IC₅₀ = 1.7 μM)^[4].
Quercetagitrin (2.5-5 μM, 6 h) increases glucose absorption in the prescence of insulin in differentiated C2C12 myoblasts^[4].
Quercetagitrin (5-10 μM, 6 h) increases AMPK phosphorylation in C2C12 myoblasts^[4].
Quercetagitrin (40 μM, 6 h) mitigates palmitic acid-induced insulin resistance in C2C12 myoblast through the insulin-dependent Akt pathway^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Quercetagitrin (10 μg/mL, through water feeding, 3 consecutive months) attenuates synaptic impairments and cognitive deficits in the P301S-Tau transgenic mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Six-month-old male P301S-Tau transgenic mice^[3]
Dosage:

10 μg/mL
Administration:

Through water feeding for 3 consecutive months
Result:

Remarkably decreased acetylation level at Lys174.
Reduced tau accumulation in the hippocampus and the cortex.
Prevented augmented GSK3β activity in the hippocampus.
Reduced tau oligomerization.
Prominently limited astrogliosis and microglia activation in the hippocampus of P301S-tau transgenic mice.
Partially elevated synaptophysin expression and efficiently ameliorated the memory deficits in P301S-tau transgenic mice, evidenced by decreased latency in reaching the target platform region.
Reduced gliosis, neuronal loss, synaptic impairments and cognitive deficits.

化学情報

CAS 番号 548-75-4
性状 Solid
分子量 480.38
分子式 C₂₁H₂₀O₁₃
Color Light yellow to yellow
SMILES

O=C1C2=C(O)C(O)=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2OC(C4=CC(O)=C(O)C=C4)=C1O
別名

Quercetagetin-7-O-glucoside
Structure Classification
- Flavonoids
- Flavonols
- Phenols
- Polyphenols
Initial Source
- Plants
- Compositae
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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ACS Omega

Quercetagitrin Ameliorates Alzheimer-Like Pathologies Associated with TNFα/NFκB Pathway in APP/PS1 Mice. [Abstract]

2025 Oct 16;10(42):49816-49827. PMID: 41179212

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (260.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0817 mL

10.4084 mL

20.8169 mL

5 mM

0.4163 mL

2.0817 mL

4.1634 mL

10 mM

0.2082 mL

1.0408 mL

2.0817 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
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- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
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MS (2659 KB)
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IR (2659 KB)
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Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. BY P. SURYAPRAKASA RAO, et al. Isolation and constitution of quercetagitrin, a glucoside of quercetagetin. Proceedings of the Indian Academy of Sciences - Section A. 1941.

[2]. Tordera M, et al. Influence of anti-inflammatory flavonoids on degranulation and arachidonic acid release in rat neutrophils. Z Naturforsch C. 1994 Mar-Apr;49(3-4):235-40. [Content Brief]

[3]. Zhong, S., et al., (2023). Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice. Molecules (Basel, Switzerland), 28(9), 3964. [Content Brief]

[4]. Gone, G. B., et al., (2024). Exploring the Anti-Diabetic Potential of Quercetagitrin through Dual Inhibition of PTPN6 and PTPN9. Nutrients, 16(5), 647. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0817 mL	10.4084 mL	20.8169 mL	52.0421 mL
	5 mM	0.4163 mL	2.0817 mL	4.1634 mL	10.4084 mL
	10 mM	0.2082 mL	1.0408 mL	2.0817 mL	5.2042 mL
	15 mM	0.1388 mL	0.6939 mL	1.3878 mL	3.4695 mL
	20 mM	0.1041 mL	0.5204 mL	1.0408 mL	2.6021 mL
	25 mM	0.0833 mL	0.4163 mL	0.8327 mL	2.0817 mL
	30 mM	0.0694 mL	0.3469 mL	0.6939 mL	1.7347 mL
	40 mM	0.0520 mL	0.2602 mL	0.5204 mL	1.3011 mL
	50 mM	0.0416 mL	0.2082 mL	0.4163 mL	1.0408 mL
	60 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.8674 mL
	80 mM	0.0260 mL	0.1301 mL	0.2602 mL	0.6505 mL
	100 mM	0.0208 mL	0.1041 mL	0.2082 mL	0.5204 mL

Keywords

Quercetagitrin

1 Cited Publications

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Quercetagitrin

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MedChemExpress（MCE）の使用を引用している文献 Quercetagitrin

NF-κB アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Quercetagitrin 関連分類

製品番号: HY-N4150