Ranakinin

Ranakinin potently binds to and inhibits the binding of selective tachykinin NK1 receptor radioligands to membrane binding sites in rat submandibular glands, with an IC₅₀ of 1.6 nM^[1].
Ranakinin (10^-9-10^-5 M; 20 sec) stimulates the production of IP₃, IP₂ and IP₁ in a time- and dose-dependent manner, and decreases the concentrations of PIP₂ and PIP in a time- and dose-dependent manner, with no effect on PI levels, in myo-[³H]inositol-prelabeled adrenal tissues of Rana ridibunda^[2].
Ranakinin (10^-5 M; 20 min) doubles the secretions of corticosterone and aldosterone from perfused adrenal explants of Rana ridibunda^[2].
Ranakinin (at different competitor concentrations; incubated for 60 min at 25 °C) binds to bufokinin (bNK₁) receptors in intestinal smooth muscle membrane homogenates of Bufo marinus, with an IC₅₀ of 2.8 nM, exhibiting high binding affinity almost comparable to that of bufokinin^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.