Rinucumab
Based on 1 Customer Validation
Rinucumab (REGN 2176) is an anti-PDGFR-β antibody. Rinucumab is used for research on neovascular age-related macular degeneration.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.9%
- CAS 番号: 1569263-06-4
- 分子量:145.5 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
PDGFR-β |
体外実験
Rinucumab can be used in combination with Aflibercept (HY-108801) for vision research[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
遺伝子ID
アクセッション番号
NP_002600.1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized PDGF-BB Protein, Human can bind Rinucumab. The EC50 for this effect is 10.71 ng/mL. -
化学情報
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CAS 番号 1569263-06-4
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性状 Liquid
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分子量 145.5 kDa
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Color Colorless to light yellow
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SMILES
[Rinucumab]
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別名
REGN 2176
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Dunn EN, et al. An Overview of the Fovista and Rinucumab Trials and the Fate of Anti-PDGF Medications. Ophthalmic Surg Lasers Imaging Retina. 2017 Feb 1;48(2):100-104. [Content Brief]
[2]. Megan Cully, et al. Deal watch: Novartis eyes vision-enhancing therapy for macular degeneration. Nat Rev Drug Discov. 2014 Jul;13(7):487. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)