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製品番号: HY-187608

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Ro 44-3888

Ro 44-3888 is an orally active and selective GP IIb-IIIa (fibrinogen receptor, integrin α_IIbβ₃) inhibitor with an IC₅₀ of 1.9 nM against the human target. Ro 44-3888 blocks the binding of fibrinogen to GP IIb-IIIa and inhibits human ADP-induced platelet aggregation. Ro 44‑3888 is formed via the metabolism of the double prodrug Ro 48‑3657 (HY-10309). Ro 44-3888 is used in studies related to arterial thrombosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 144412-18-0
分子式: C₁₈H₂₄N₄O₅
分子量:376.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ro 44-3888 構造式

CAS 番号: 144412-18-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
プロトコル (1)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

GPIIb/IIIa

1.9 nM (IC₅₀)

Integrin アイソフォーム固有の製品をすべて表示 :

体外実験

Ro 44-3888 (compound 13) potently inhibits the binding of fibrinogen to purified human GP IIb-IIIa with an IC₅₀ of 1.9 nM, and effectively suppresses ADP-induced platelet aggregation in human platelet-rich plasma with an IC₅₀ of 38 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

体内実験

Ro 44-3888 (compound 13) is generated via in vivo metabolism after oral administration of Ro 48‑3657 (HY-10309). Its bioavailability is 26 % in rats, 25 % in dogs, and 33 % in rhesus monkeys; the corresponding elimination half-lives are 4.1 h, 11.4 h, and 5.1 h, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 144412-18-0
分子量 376.41
分子式 C₁₈H₂₄N₄O₅
SMILES

O=C(N1CCC(CC1)OCC(O)=O)[C@H](C)NC(C2=CC=C(C=C2)C(N)=N)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Weller T, et al. Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines. Journal of medicinal chemistry. 1996 Aug 02;39(16):3139-47.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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