Robenacoxib
Based on 1 Customer Validation
Robenacoxib is a nonsteroidal anti-inflammatory and analgesic agent. Robenacoxib is a selective COX-2 inhibitor.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.08%
- CAS 番号: 220991-32-2
- 分子式: C16H13F4NO2
- 分子量:327.27
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
化学情報
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CAS 番号 220991-32-2
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性状 Solid
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分子量 327.27
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分子式 C16H13F4NO2
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Color Off-white to light yellow
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SMILES
O=C(CC1=CC(CC)=CC=C1NC2=C(C(F)=CC(F)=C2F)F)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外:
DMSO : 125 mg/mL (381.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
純度とドキュメンテーション
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データシート (269 KB)
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SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kongara K, et al. Robenacoxib in the treatment of pain in cats and dogs: safety, efficacy, and place in therapy. Vet Med (Auckl). 2018 Aug 15;9:53-61. [Content Brief]
[2]. Schmid VB, et al. Analgesic and anti-inflammatory actions of robenacoxib in acute joint inflammation in dog. J Vet Pharmacol Ther. 2010 Apr;33(2):118-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0556 mL | 15.2779 mL | 30.5558 mL | 76.3895 mL |
| 5 mM | 0.6111 mL | 3.0556 mL | 6.1112 mL | 15.2779 mL | |
| 10 mM | 0.3056 mL | 1.5278 mL | 3.0556 mL | 7.6390 mL | |
| 15 mM | 0.2037 mL | 1.0185 mL | 2.0371 mL | 5.0926 mL | |
| 20 mM | 0.1528 mL | 0.7639 mL | 1.5278 mL | 3.8195 mL | |
| 25 mM | 0.1222 mL | 0.6111 mL | 1.2222 mL | 3.0556 mL | |
| 30 mM | 0.1019 mL | 0.5093 mL | 1.0185 mL | 2.5463 mL | |
| 40 mM | 0.0764 mL | 0.3819 mL | 0.7639 mL | 1.9097 mL | |
| 50 mM | 0.0611 mL | 0.3056 mL | 0.6111 mL | 1.5278 mL | |
| 60 mM | 0.0509 mL | 0.2546 mL | 0.5093 mL | 1.2732 mL | |
| 80 mM | 0.0382 mL | 0.1910 mL | 0.3819 mL | 0.9549 mL | |
| 100 mM | 0.0306 mL | 0.1528 mL | 0.3056 mL | 0.7639 mL |
Robenacoxib 関連分類
HY-118078 関連分類
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