Robenacoxib-d5
Based on 1 Customer Validation
Robenacoxib-d5 is deuterium-labeled Robenacoxib (HY-118078).
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 2012598-81-9
- Formula: C16H8D5F4NO2
- Molecular Weight:332.30
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable or radioisotope-labeled compounds allow precise tracking and quantification of individual atoms in metabolic pathways. Stable isotopes generally do not change molecular properties but may slightly affect metabolic kinetics; radioactive isotopes may interfere with cells. Markers can distinguish endogenous and exogenous metabolites, reduce false positives, and are beneficial to quantification and reconstruction of metabolic pathways[2].
In cell culture or enzymatic reactions, the use of isotope markers can precisely control the concentration and exposure time, making it easy to study metabolic reactions and enzyme activities. Through stable isotope analytical metabolomics (SIRM), cellular metabolic networks can be studied, key metabolic nodes and regulatory mechanisms can be identified, and targets can be provided for compound development.
Isotope-labeled compounds can be used in competition binding experiments to evaluate the affinity and binding kinetics of compounds to receptors to help optimize design. Stable isotope labels are used as internal standards in mass spectrometry analysis to improve analysis accuracy and reproducibility and reduce matrix effect interference[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms and evaluate unexpected side effects, improving the accuracy and efficiency of clinical research[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2012598-81-9
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Unlabeled Cas 220991-32-2
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Appearance Solid
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Molecular Weight 332.30
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Formula C16H8D5F4NO2
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Color White to off-white
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SMILES
O=C(CC1=CC(C([2H])([2H])C([2H])([2H])[2H])=CC=C1NC2=C(C(F)=CC(F)=C2F)F)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (376.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Smith K A, et al. Soil and environmental analysis[M]. Marcel Dekker Incorporated, 2000.
[3]. Fan T W M, et al. Stable isotope-resolved metabolomics and applications for drug development[J]. Pharmacology & therapeutics, 2012, 133(3): 366-391. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0093 mL | 15.0466 mL | 30.0933 mL | 75.2332 mL |
| 5 mM | 0.6019 mL | 3.0093 mL | 6.0187 mL | 15.0466 mL | |
| 10 mM | 0.3009 mL | 1.5047 mL | 3.0093 mL | 7.5233 mL | |
| 15 mM | 0.2006 mL | 1.0031 mL | 2.0062 mL | 5.0155 mL | |
| 20 mM | 0.1505 mL | 0.7523 mL | 1.5047 mL | 3.7617 mL | |
| 25 mM | 0.1204 mL | 0.6019 mL | 1.2037 mL | 3.0093 mL | |
| 30 mM | 0.1003 mL | 0.5016 mL | 1.0031 mL | 2.5078 mL | |
| 40 mM | 0.0752 mL | 0.3762 mL | 0.7523 mL | 1.8808 mL | |
| 50 mM | 0.0602 mL | 0.3009 mL | 0.6019 mL | 1.5047 mL | |
| 60 mM | 0.0502 mL | 0.2508 mL | 0.5016 mL | 1.2539 mL | |
| 80 mM | 0.0376 mL | 0.1881 mL | 0.3762 mL | 0.9404 mL | |
| 100 mM | 0.0301 mL | 0.1505 mL | 0.3009 mL | 0.7523 mL |
Robenacoxib-d5 Related Classifications
HY-118078S Related Classifications
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