RU28362
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 74915-64-3
- 分子式: C23H28O3
- 分子量:352.47
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
BNIP3 |
RU28362 (0.1, 1, 5, 10 nM; 72 h) increases the Bnip3 mRNA levels in a dose-dependent manner after 72 h in neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Primary cortical neurons
-
Concentration:0.1, 1.0, 5.0, 10.0 nM
-
Incubation Time:48, 72 h
-
Result:Significantly increased the Bnip3 mRNA levels in a dose-dependent manner after 72 h, Bnip3 mRNA levels were not changed after treatment with RU28362 for 48 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:250-350 g, adult male Sprague-Dawley rats[2]
-
Dosage:150 µg/kg
-
Administration:I.p.; 60 min before exposure to a 15-min period of restraint stress
-
Result:Inhibited adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland.
化学情報
-
CAS 番号 74915-64-3
-
分子量 352.47
-
分子式 C23H28O3
-
SMILES
O=C1C=C[C@@]2([C@]3([C@H](C[C@@]4([C@@](O)(CC[C@]4([C@@]3(C=C(C2=C1)C)[H])[H])C#CC)C)O)[H])C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144(2):482-94. [Content Brief]
[2]. Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RU28362 関連分類
HY-121859 関連分類
Powered by Bioz