SCP-7
SCP-7 is a STAT3 inhibitor with a Kd value of 795 nM. SCP-7 induces mitochondrial dysfunction, increases ROS levels and promotes apoptosis. SCP-7 induces G2/M phase arrest of the cell cycle. SCP-7 inhibits the proliferation, migration and colony formation of colorectal cancer cells. SCP-7 suppresses tumor growth in a mouse xenograft model of colorectal cancer. SCP-7 is applicable to research related to colorectal cancer.
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- CAS 番号: 2479389-64-3
- 分子式: C22H20O6
- 分子量:380.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
STAT3 795 nM (Kd) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
3.84 μM
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Inhibition of cell viability against human HCT116 cells incubated for 48 hrs by MTT assay.
Inhibition of cell viability against human HCT116 cells incubated for 48 hrs by MTT assay.
|
42497765 |
| HT-29 | IC50 |
1.58 μM
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Inhibition of cell viability against human HT29 cells incubated for 48 hrs by MTT assay.
Inhibition of cell viability against human HT29 cells incubated for 48 hrs by MTT assay.
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42497765 |
| HEK-293T | IC50 |
18.34 μM
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Inhibition of cell viability against human HEK-293T cells incubated for 48 hrs by MTT assay.
Inhibition of cell viability against human HEK-293T cells incubated for 48 hrs by MTT assay.
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42497765 |
体外実験
SCP-7 (48 h) potently inhibits the viability of HCT116 and HT29 colorectal cancer cells with IC50 values of 3.84 μM and 1.58 μM, respectively, and exhibits reduced activity against normal HEK-293T cells[1].
SCP-7 (48 h) inhibits the proliferation of HCT116 and HT29 colorectal cancer cells[1].
SCP-7 (72 h) concentration-dependently inhibits colony formation by HCT116 and HT29 colorectal cancer cells[1].
SCP-7 (0.25 μM-1 μM; 12 h, 24 h) inhibits the migration of HCT116 and HT29 colorectal cancer cells[1].
SCP-7 (48 h) induces apoptosis in HCT116 and HT29 colorectal cancer cells, as evidenced by increased apoptotic cell proportions and altered expression of BAX, Bcl-2, Mcl-1, and survivin[1].
SCP-7 (2.5 μM-10 μM; 48 h) induces mitochondrial dysfunction and oxidative stress in HCT116 and HT29 colorectal cancer cells[1].
SCP-7 (2.5 μM-10 μM; 48 h) induces G2/M phase cell cycle arrest in HCT116 and HT29 colorectal cancer cells, accompanied by reduced cyclin B1 and CDK1 expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116, HT29
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Concentration:0, 0.5, 1 and 2 μM
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Incubation Time:12 h, 24 h
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Result:Inhibited the migration.
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Cell Line:inhibits the migration
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Concentration:0, 2.5, 5 and 10 μM
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Incubation Time:48 h
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Result:Induced cell apoptosis.
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Cell Line:inhibits the migration
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Concentration:0, 0.625, 1.25, 2.5, 5 and 10 μM
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Incubation Time:48 h
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Result:Upregulated BAX.
Downregulated Bcl-2, Mcl-1, survivin and c-Myc.
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Cell Line:HCT116, HT29
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Concentration:0, 2.5, 5 and 10 μM
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Incubation Time:48 h
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Result:Increased the proportion of cells in the G2/M phase in a concentration-dependent manner in both HCT116 and HT29 cells.
Significantly reduced cyclin B1 and CDK1 expression levels in both cell lines.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice[1]
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Dosage:2.5 mg/kg; 5 mg/kg
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Administration:i.p.; once every two days; 14 days
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Result:Suppressed HCT116 xenograft tumor growth in a dose-dependent manner.
Reduced tumor weight and volume significantly compared to the control group.
Reduced Ki67 and p-STAT3 levels in tumor tissue.
Increased BAX levels in tumor tissue.
Downregulated downstream STAT3 targets c-Myc and Bcl-2.
Caused no significant changes in mouse body weight during treatment.
Showed no significant toxicity via organ index analysis, H&E staining of major organs, and serum levels of ALT, AST, CRE, and TBIL.
化学情報
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CAS 番号 2479389-64-3
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分子量 380.39
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分子式 C22H20O6
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SMILES
O=C(C1=CC=CC=C1)O[C@@H]2/C=C(C)/C[C@H](OC3=O)C=C3C[C@H]4[C@H]2C(C(O4)=O)=C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SCP-7 関連分類
HY-187792 関連分類
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