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製品番号: HY-117357

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SI-113

カスタマーレビュー

Based on 1 Customer Validation

SI-113 is a SGK1 inhibitor, with an IC₅₀ of 600 nM. SI113 induces autophagy.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.09%
CAS 番号: 1392816-46-4
分子式: C₂₃H₂₄N₆O
分子量:400.48

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SI-113 構造式

CAS 番号: 1392816-46-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

SI-113 is a SGK1 inhibitor, with an IC₅₀ of 600 nM. SI113 induces autophagy^[1]^[2].

SGK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	25.64 μM Compound: 2; Si113	Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 34161866]
A2780	IC₅₀	3.47 μM Compound: 2; Si113	Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 34161866]
A2780	IC₅₀	4.56 μM Compound: 2; Si113	Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human A2780 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34161866]
HepG2	IC₅₀	15.87 μM Compound: 2; Si113	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 34161866]
HepG2	IC₅₀	3.15 μM Compound: 2; Si113	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 34161866]
HepG2	IC₅₀	8.29 μM Compound: 2; Si113	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34161866]
Huh-7	IC₅₀	0.58 μM Compound: 2; Si113	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 34161866]
Huh-7	IC₅₀	1.88 μM Compound: 2; Si113	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34161866]
Huh-7	IC₅₀	2.05 μM Compound: 2; Si113	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 34161866]

体外実験

SI-113 exhibits IC₅₀ values of 10.5, 14.4 and 10.7 μM in GIN8, GIN28 and GCE28 GBM cells^[1].
SI-113 induces significant increases in caspase-3/7 activation in all GBM cell lines^[1].
SI-113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1392816-46-4
性状 Solid
分子量 400.48
分子式 C₂₃H₂₄N₆O
Color White to off-white
SMILES

OCCNC1=NC(NCCC2=CC=CC=C2)=C3C(N(/C=C/C4=CC=CC=C4)N=C3)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 250 mg/mL (624.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4970 mL

12.4850 mL

24.9700 mL

5 mM

0.4994 mL

2.4970 mL

4.9940 mL

10 mM

0.2497 mL

1.2485 mL

2.4970 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Marco Radi , et al. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5579-83. [Content Brief]

[2]. Silvia Matteoni, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4970 mL	12.4850 mL	24.9700 mL	62.4251 mL
	5 mM	0.4994 mL	2.4970 mL	4.9940 mL	12.4850 mL
	10 mM	0.2497 mL	1.2485 mL	2.4970 mL	6.2425 mL
	15 mM	0.1665 mL	0.8323 mL	1.6647 mL	4.1617 mL
	20 mM	0.1249 mL	0.6243 mL	1.2485 mL	3.1213 mL
	25 mM	0.0999 mL	0.4994 mL	0.9988 mL	2.4970 mL
	30 mM	0.0832 mL	0.4162 mL	0.8323 mL	2.0808 mL
	40 mM	0.0624 mL	0.3121 mL	0.6243 mL	1.5606 mL
	50 mM	0.0499 mL	0.2497 mL	0.4994 mL	1.2485 mL
	60 mM	0.0416 mL	0.2081 mL	0.4162 mL	1.0404 mL
	80 mM	0.0312 mL	0.1561 mL	0.3121 mL	0.7803 mL
	100 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
化学情報
溶剤 & 溶解度
- 体外実験
純度とドキュメンテーション
参考文献

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SI-113

Kinase Inhibitor Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Metabolic Enzyme Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

SGK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

SI-113

Kinase Inhibitor Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Metabolic Enzyme Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

SGK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

SI-113 関連分類

HY-117357 関連分類