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Sutacimig

(別名: HMB-001)
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Based on 1 Customer Validation

Sutacimig (HMB-001) is a humanized antibody of the (H-γ4_L-κ)_(H-γ4_L-κ) format that targets FⅦa/TREML1. One arm of Sutacimig binds to endogenous FVIIa, thereby prolonging the half-life of FVIIa and increasing its accumulation in the bloodstream, while the other arm binds to TLT-1, which is exclusively expressed on the surface of activated platelets. This localizes endogenous FVIIa to activated platelets, further enhancing the activity of FVIIa. Sutacimig enhances Thrombin generation, fibrin formation, and the formation of stable fibrin-platelet networks at sites of vascular injury. Sutacimig can be used in studies related to Glanzmann thrombasthenia.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.08%
  • CAS 番号: 2933972-64-4
  • 分子量:144.54 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Sutacimig
  • Experimental Validation Results for Sutacimig
  • Experimental Validation Results for Sutacimig
  • Sutacimig Chemical Structure
    Sutacimig 構造式
CAS 番号: 2933972-64-4
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG4-kappa

  • 1/16

    Immobilized Coagulation factor VII/F7 Protein, Human (HEK293, His, HY-P78763) can bind Sutacimig. The EC50 for this effect is 10.01 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 Jurkat cells with Sutacimig (HY-P991029, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Sutacimig Chemical Structure
    1/16
  • Sutacimig
  • Immobilized Coagulation factor VII/F7 Protein, Human (HEK293, His, HY-P78763) can bind Sutacimig. The EC50 for this effect is 10.01 ng/mL.
  • Flow cytometric analysis of 1.5×106 Jurkat cells with Sutacimig (HY-P991029, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG4-kappa