Thiocoumarin
Thiocoumarin is a carbonic anhydrase (CA) inhibitor, with Ki values of 0.047 μM, 0.042 μM, and 0.1 μM against hCA IX, mCA XIII, and hCA I, respectively; its Ki values against hCA IV, mCA XV, hCA II, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, and hCA XIV are 4.1, 4.8, 6.2, 8.4, 7.5, 8.8, 7.3, 8.7, and 7.4 μM, respectively. As a photocage molecule, Thiocoumarin undergoes photolysis upon illumination to release the caged molecule, and it exhibits red-shifted absorption properties and rapid photolysis kinetics. Thiocoumarin can be used in cancer-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3986-98-9
- 分子式: C9H6OS
- 分子量:162.21
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Thiocoumarin-caged ATP is rapidly and cleanly uncaged to release ATP upon irradiation with 490 nm light (full release within 4 min at all tested intensities) or 400 nm light (full release within 30 s at 50% intensity) at a concentration of 1 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3986-98-9
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分子量 162.21
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分子式 C9H6OS
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SMILES
S=C1OC2=C(C=C1)C=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ma J, et al. Thiocoumarin Caged Nucleotides: Synthetic Access and Their Photophysical Properties. Molecules (Basel, Switzerland). 2020 Nov 15;25(22):5325. [Content Brief]
[2]. Maresca A, et al. Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. Journal of medicinal chemistry. 2010 Jan 14;53(1):335-44. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Thiocoumarin 関連分類
HY-183522 関連分類
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