製品番号: HY-117469

Triptohypol C

カスタマーレビュー

Based on 1 Customer Validation

Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an K_d value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 96.56%
CAS 番号: 193957-88-9
分子式: C₂₉H₄₀O₄
分子量:452.63

保管条件:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Triptohypol C 構造式

CAS 番号: 193957-88-9

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

Nur77/NR4A1

Nuclear Hormone Receptor 4A/NR4A アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.15 μM Compound: 2	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 28688281]
A549	IC₅₀	3.15 μM Compound: 2	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 28865279]
MIA PaCa-2	IC₅₀	0.72 μM Compound: 2	Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay	[PMID: 28688281]
MIA PaCa-2	IC₅₀	0.72 μM Compound: 2	Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay	[PMID: 28865279]

体外実験

Triptohypol C (compound 3a) (2 μM; 1 h) strongly antagonize the effect of TNFα on inducing IκBα degradation, and inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1^[1].
Triptohypol C (2 μM; 10 h) cause 3.12% apoptosis in HepG2 cells, which is less toxic than Tripterin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Lysates from HepG2 cells (incubated with 20 ng/mL TNFα for 30 min)
Concentration:

2 μM
Incubation Time:

1 h
Result:

Strongly antagonized the effect of TNFα on inducing IκBα degradation

Immunofluorescence^[1]

Cell Line:

HepG2 cells (transfected with Myc-Nur77 and Flag-TRAF2 or Flag-p62)
Concentration:

2 μM
Incubation Time:

1 h
Result:

Promoted the interactions between Nur77 and TRAF2 and p62/SQSTM1.

Apoptosis Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

2 μM
Incubation Time:

10 h
Result:

Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).

体内実験

Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Zebrafish^[1]
Dosage:

0.5 μM, 1 μM and 1.25 μM
Administration:

72 h
Result:

Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25 μM for 24 h or at a concentration of 0.5 μM for 72 h.

化学情報

CAS 番号 193957-88-9
性状 Solid
分子量 452.63
分子式 C₂₉H₄₀O₄
Color Light yellow to yellow
SMILES

CC1=C(O)C(O)=CC2=C1CC=C3[C@@]2(C)CC[C@]4(C)[C@]3(C)CC[C@]5(C)[C@@]4([H])C[C@](C)(C(O)=O)CC5
Structure Classification
- Terpenoids
- Triterpenes
- Ketones, Aldehydes, Acids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 16.67 mg/mL (36.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2093 mL

11.0465 mL

22.0931 mL

5 mM

0.4419 mL

2.2093 mL

4.4186 mL

10 mM

0.2209 mL

1.1047 mL

2.2093 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2093 mL	11.0466 mL	22.0931 mL	55.2328 mL
	5 mM	0.4419 mL	2.2093 mL	4.4186 mL	11.0466 mL
	10 mM	0.2209 mL	1.1047 mL	2.2093 mL	5.5233 mL
	15 mM	0.1473 mL	0.7364 mL	1.4729 mL	3.6822 mL
	20 mM	0.1105 mL	0.5523 mL	1.1047 mL	2.7616 mL
	25 mM	0.0884 mL	0.4419 mL	0.8837 mL	2.2093 mL
	30 mM	0.0736 mL	0.3682 mL	0.7364 mL	1.8411 mL

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Triptohypol C

Immunology/Inflammation Compound Library

Natural Product Library

Autophagy Compound Library

Terpenoids Library

Plant-Sourced Natural Product Library

Nuclear Receptor Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Nuclear Hormone Receptor 4A/NR4A アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Triptohypol C

Immunology/Inflammation Compound Library

Natural Product Library

Autophagy Compound Library

Terpenoids Library

Plant-Sourced Natural Product Library

Nuclear Receptor Compound Library

Mitophagy Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Nuclear Hormone Receptor 4A/NR4A アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Triptohypol C 関連分類

HY-117469 関連分類