TSI-01
Based on 1 Customer Validation
TSI-01 is a selective LPCAT2 inhibitor, with IC50 values of 0.47 μM and 3.02 μM against LPCAT2 and LPCAT1, respectively. TSI-01 competitively inhibits acetyl-CoA (acetyl-CoA) targeting the lysophosphatidic acid acetyltransferase activity of LPCAT2, and suppresses PAF biosynthesis in calcium ionophore-stimulated mouse peritoneal macrophages. TSI-01 inhibits the proliferation of endometrial cancer cells and promotes endometrial cancer cell apoptosis (apoptosis). TSI-01 can be used for the research of endometrial cancer and PAF-related inflammatory diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.52%
- CAS 番号: 704878-75-1
- 分子式: C14H11Cl2NO4
- 分子量:328.15
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Bioactive Compound Library Max
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Bioactive Compound Library
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Immunology/Inflammation Compound Library
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
HY-L150
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Cysteine Targeted Covalent Library
HY-L153
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Highly Selective Inhibitors Library
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Macrophage Related Compound Library
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MCE Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Lactylation Compound Library
HY-L249
生物活性
TSI-01 (0-40 μM) potently inhibits the viability of human endometrial cancer Ishikawa cells with an IC50 of 7.56 μM and HEC-1A cells with an IC50 of 9.31 μM[1].
TSI-01 (0-10 μM) concentration-dependently promotes apoptosis in human endometrial cancer Ishikawa and HEC-1A cells, with 10 μM inducing the highest levels of early and late apoptosis[1].
TSI-01 (0.1-100 μM; 1 h) dose-dependently inhibits A23187-induced PAF production in RAW-mLPCAT2 cells with an IC50 of 38.8 μM, without reducing cell viability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 704878-75-1
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性状 Solid
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分子量 328.15
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分子式 C14H11Cl2NO4
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Color White to off-white
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SMILES
O=C(C1=CC=C(N2C(C(Cl)=C(C2=O)Cl)=O)C=C1)OC(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (380.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Zhao T, et al. Overexpression of LPCAT1 enhances endometrial cancer stemness and metastasis by changing lipid components and activating the TGF/β-Smad2/3 signaling pathway. Acta biochimica et biophysica Sinica. 2022 Jun 25;54(7):904-916. [Content Brief]
[2]. Tarui M, et al. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. Journal of lipid research. 2014 Jul;55(7):1386-96. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0474 mL | 15.2369 mL | 30.4739 mL | 76.1847 mL |
| 5 mM | 0.6095 mL | 3.0474 mL | 6.0948 mL | 15.2369 mL | |
| 10 mM | 0.3047 mL | 1.5237 mL | 3.0474 mL | 7.6185 mL | |
| 15 mM | 0.2032 mL | 1.0158 mL | 2.0316 mL | 5.0790 mL | |
| 20 mM | 0.1524 mL | 0.7618 mL | 1.5237 mL | 3.8092 mL | |
| 25 mM | 0.1219 mL | 0.6095 mL | 1.2190 mL | 3.0474 mL | |
| 30 mM | 0.1016 mL | 0.5079 mL | 1.0158 mL | 2.5395 mL | |
| 40 mM | 0.0762 mL | 0.3809 mL | 0.7618 mL | 1.9046 mL | |
| 50 mM | 0.0609 mL | 0.3047 mL | 0.6095 mL | 1.5237 mL | |
| 60 mM | 0.0508 mL | 0.2539 mL | 0.5079 mL | 1.2697 mL | |
| 80 mM | 0.0381 mL | 0.1905 mL | 0.3809 mL | 0.9523 mL | |
| 100 mM | 0.0305 mL | 0.1524 mL | 0.3047 mL | 0.7618 mL |
TSI-01 関連分類
HY-112825 関連分類
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