VRT-18858
VRT-18858 (RU-36384), the active metabolite of Pralnacasan (HY-19676), is a potent interleukin-1β converting enzyme (ICE) inhibitor (Ki = 1.4 nM). VRT-18858 inhibits LPS (HY-D1056)-induced IL-1β release (IC50 = 0.42 µM) and S. aureus Cowan-induced IL-1β and IL-18 release (IC50=1.3 and 2.1 µM, respectively) in human peripheral blood mononuclear cells. VRT-18858 can be used for osteoarthritis research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 192756-07-3
- 分子式: C24H25N5O7
- 分子量:495.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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IL-1β |
IL-18 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
0.38 μM
Compound: 2a
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Inhibition of LPS-induced IL1-beta production in human PBMC by ELISA
Inhibition of LPS-induced IL1-beta production in human PBMC by ELISA
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[PMID: 20656488] |
| PBMC | IC50 |
0.85 μM
Compound: VRT-18858
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Inhibition of LPS-induced IL-1beta release in PBMC (unknown origin)
Inhibition of LPS-induced IL-1beta release in PBMC (unknown origin)
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[PMID: 34823899] |
化学情報
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CAS 番号 192756-07-3
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分子量 495.48
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分子式 C24H25N5O7
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SMILES
O=C([C@@H](NC(C1=NC=CC2=C1C=CC=C2)=O)CC3)N([C@H](C(N[C@H](C=O)CC(O)=O)=O)CCC4)N4C3=O
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別名
RU-36384
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
VRT-18858 関連分類
HY-125577 関連分類
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