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Cat. No.: HY-189084

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PSB-10

PSB-10 is a selective human adenosine A3 receptor antagonist that antagonizes adenosine-mediated signaling. PSB-10 can be used in the study of breast cancer.

For research use only. We do not sell to patients.

CAS No.: 439902-54-2
Formula: C₁₆H₁₄Cl₃N₅O
Molecular Weight:398.67

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Please store the product under the recommended conditions in the Certificate of Analysis.

PSB-10 Chemical Structure

CAS No.: 439902-54-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Description

PSB-10 is a selective human adenosine A3 receptor antagonist that antagonizes adenosine-mediated signaling. PSB-10 can be used in the study of breast cancer^[1]^[2].

IC₅₀ & Target

^[1]

Adenosine A₃ receptor

All Adenosine Receptor Isoforms :

In Vitro

Anti-cancerLocal Vascular Regulation

Anti-cancer

Local Vascular Regulation

PSB-10 (1 µM; Day 0-7) increases GFP-MDA-231 breast CC density to 172.8% of control and partially compromises vascular network formation in the MMm^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Breast Cancer Modeling

Chemical Information

CAS No. 439902-54-2
Molecular Weight 398.67
Formula C₁₆H₁₄Cl₃N₅O
SMILES

CN1C2=C(NC(C3=C(C(Cl)=CC(Cl)=C3)Cl)=N2)C4=N[C@H](CC)CN4C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Colombo MV, et al. Engineering the early bone metastatic niche through human vascularized immuno bone minitissues. Biofabrication. 2021 Apr 26;13(3).

[2]. Bednarska K, et al. Effect of adenosine modified with a boron cluster pharmacophore on reactive oxygen species production by human neutrophils. Bioorganic & medicinal chemistry. 2012 Nov 15;20(22):6621-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
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PSB-10

All Adenosine Receptor Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PSB-10 Related Classifications

HY-189084 Related Classifications

Bioz

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