country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N15384

Copy Link Print Information

Wrightiadione

Wrightiadione is a selective natural tetracyclic isoflavone kinase inhibitor with inhibitory activity against TrkA and PLK3. The IC₅₀ values of Wrightiadione against TrkA and PLK3 are 55.8 μM and 9.0 μM, respectively. Wrightiadione is found in the dried bark of Wrightia tomentosa. Wrightiadione can be used in studies of leukemia, kinase inhibition and cancer-related signaling pathways.

For research use only. We do not sell to patients.

CAS No.: 148180-61-4
Formula: C₁₆H₈O₃
Molecular Weight:248.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Wrightiadione Chemical Structure

CAS No.: 148180-61-4

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

TrkA

55.8 μM (IC₅₀)

PLK3

9 μM (IC₅₀)

All Trk Receptor Isoforms :

All Polo-like Kinase (PLK) Isoforms :

In Vitro

Wrightiadione (compound 1) at 10 μM selectively inhibits TrkA and PLK3 against a kinome panel consisting of 97 cancer-related kinases in a high-throughput binding assay^[1].
Wrightiadione inhibits the activity of purified TrkA kinase in radiokinase assays, with an IC₅₀ value of 55.8 μM^[1].
Wrightiadione inhibits the kinase activity of purified PLK3 in radiometric kinase assays, with an IC₅₀ of 9.0 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 148180-61-4
Molecular Weight 248.24
Formula C₁₆H₈O₃
SMILES

O=C1C=2OC=3C=CC=CC3C(=O)C2C=4C=CC=CC14
Structure Classification
- Flavonoids
- Isoflavones
- Flavonoids
- Other Flavonoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jeong Y, et al. Discovery of wrightiadione as a novel template for the TrkA kinase inhibitors. Bioorganic & medicinal chemistry letters. 2015 Nov 15;25(22):5186-9.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

Wrightiadione

All Trk Receptor Isoforms

All Polo-like Kinase (PLK) Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Wrightiadione Related Classifications

HY-N15384 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target