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CB-5083

53 Cited Publications
고객리뷰

Based on 53 publication(s) in Google Scholar

CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC50 of 11 nM.

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  • Purity: 99.90%
  • CAS No.: 1542705-92-9
  • 화학식: C24H23N5O2
  • 분자량:413.47
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • CB-5083 Chemical Structure
    CB-5083 Chemical Structure
  • Experimental Validation Results for CB-5083
  • Experimental Validation Results for CB-5083
  • Experimental Validation Results for CB-5083
  • Experimental Validation Results for CB-5083
  • Experimental Validation Results for CB-5083
CAS No.: 1542705-92-9
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  • CB-5083 Chemical Structure
    CB-5083 Chemical Structure
    1/16
  • 1/16

    CB-5083 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Jan 24;10(1):26. [Abstract]

    Customer Validation
     CB-5083 (0-2 μM; 24 h). Immunoblot analysis of the indicated proteins in HCCLM3 cells treated with gradient concentrations of CB-5083 or Vehicle for 24 h.

  • 1/16

    CB-5083 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Jan 24;10(1):26. [Abstract]

    Customer Validation
     CB-5083 (50 mg/kg; oral gavage). Hepa1-6 tumors were dissected from the C57BL/6 mice treated with vehicle, CB-5083, aPD1, or both.

  • 1/16

    CB-5083 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Jan 24;10(1):26. [Abstract]

    Customer Validation
     CB-5083 (50 mg/kg; oral gavage). The percentage of CD8+T cells in Hepa1-6 tumors were measured by flow cytometry analysis.

  • 1/16

    CB-5083 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 12;16(1):11092. [Abstract]

    Customer Validation
     Western blotting analysis of RKIP expression in HeLa cells treated with PA, PA plus CB-5083 (2.5 μM) or Vehicle for 12 hrs.

  • 1/16

    CB-5083 purchased from MedChemExpress. Usage Cited in: Leukemia. 2019 Jul;33(7):1675-1686. [Abstract]

    Customer Validation
     CB-5083 (0-2 μM; 6 h). Jeko-1 and Z138C cells are exposed to the indicated concentrations of CB-5083 and ACY-1215 in the presence or absence of the autophagy inhibitor chloroquine for 6 h and LC3B-II and p62 expression is assessed by immunoblot analysis.

  • CB-5083