Enterodiol
Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Anti-cancer activities.
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- CAS No.: 80226-00-2
- 화학식: C18H22O4
- 분자량:302.36
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Enterodiol (0-100 μM; 24-72 hours) results in an apoptosis rate of up to 40% in CT26 cells. Enterodiol shows no cytotoxicity toward RAW264.7 macrophages[1].
Enterodiol (0-100 μM; 24-48 hours) also suppresses the migration of CRC cells in a concentration-dependent manner. The phosphorylation of ERK, JNK, and p38 is down-regulated with Enterodiol treatment. Enterodiol (0-100 μM; 48 hours) decreases the expression levels of anti-apoptotic proteins in CRC cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-8 weeks old female BALB/c nude mice[2]
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Dosage:1 mg/kg
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Administration:Intra-tumor injection method; once every other day until day 32
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Result:A significant reduction in the tumor volume in the experimental groups compared to the PBS group.
Chemical Information
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CAS No. 80226-00-2
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분자량 302.36
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화학식 C18H22O4
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SMILES
OC[C@H](CC1=CC=CC(O)=C1)[C@@H](CC2=CC=CC(O)=C2)CO
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Shin MK, et al. Apoptotic effect of enterodiol, the final metabolite of edible lignans, in colorectal cancer cells. J Sci Food Agric. 2019;99(5):2411-2419. [Content Brief]
[2]. Liu H, et al. Enterolactone has stronger effects than enterodiol on ovarian cancer. J Ovarian Res. 2017;10(1):49. Published 2017 Jul 24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Enterodiol Related Classifications
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