MCC950 sodium
Based on 497 publication(s) in Google Scholar
MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.75%
- CAS No.: 256373-96-3
- 화학식: C20H23N2NaO5S
- 분자량:426.46
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) MCC950 sodium
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Customer Validation & Images
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WB
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Biological Activity
제품 설명
IC50 & Target
|
NLRP3 |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
>40 μM
Compound: CP-456,773
|
Inhibition of IL-6 production in human PBMC
Inhibition of IL-6 production in human PBMC
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[PMID: 32956781] |
| PBMC | IC50 |
>40 μM
Compound: CP-456,773
|
Inhibition of TNFalpha production in human PBMC
Inhibition of TNFalpha production in human PBMC
|
[PMID: 32956781] |
In Vitro
MCC950 blocks canonical and non-canonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibits NLRP3 but not AIM2, NLRC4 or NLRP1 activation. The effect of MCC950 on NLRP3 inflammasome activation is tested in mouse bone marrow derived macrophages (BMDM) and human monocyte derived macrophages (HMDM). The IC50 of MCC950 in BMDM is approximately 7.5 nM, while in HMDM it has a similar inhibitory capacity (IC50=8.1 nM). MCC950 also dose dependently inhibit IL-1β but not TNF-α secretion.MCC950 specifically blocks caspase-11-directed NLRP3 activation and IL-1β secretion upon stimulation of the non-canonical pathway. NLRC4-stimulated IL-1β and TNF-α secretion (as activated by Salmonella typhimurium) are not inhibited by MCC950 even at a concentration of 10 μM. MCC950 does not inhibit caspase-1 activation or IL-1β processing in response to S. typhimurium. The expression of pro-caspase-1 and pro-IL-1β in cell lysates is not substantially affected by MCC950 treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 256373-96-3
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Appearance Solid
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분자량 426.46
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화학식 C20H23N2NaO5S
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Color Off-white to yellow
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SMILES
O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
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Synonyms
CP-456773 sodium; CRID3 sodium salt
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선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (497)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels. [Abstract]2025 Nov 28;10(1):388. PMID: 41309549 -
Signal Transduct Target Ther
2025 Apr 25;10(1):154. PMID: 40280946 -
Nature
2023 Dec;624(7991):442-450. PMID: 37993714 -
Science
2020 Dec 4;370(6521):eaay2002. PMID: 33093214 -
Immunity
Disruption of the Na+/K+-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety. [Abstract]2024 Mar 12;57(3):495-512.e11. PMID: 38395698 -
Nat Immunol
2023 Jan;24(1):30-41. PMID: 36443515 -
Cell Mol Immunol
The role of the IL-9‒NLRP3 axis in insulin resistance and adipose tissue inflammation during diet-induced obesity. [Abstract]2025 Sep 18. PMID: 40962954 -
Cell Mol Immunol
2020 Mar;17(3):283-299. PMID: 31320730 -
Bioact Mater
Lysosomal destabilization: A missing link between pathological calcification and osteoarthritis. [Abstract]2023 Dec 14:34:37-50. PMID: 38173842 -
Autophagy
Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. [Abstract]2021 Oct;17(10):2975-2990. PMID: 33345685 -
Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175 -
Nat Commun
Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18. [Abstract]2025 Jul 2;16(1):6074. PMID: 40603850 -
Nat Commun
Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus. [Abstract]2023 Feb 16;14(1):872. PMID: 36797275 -
Nat Commun
Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV. [Abstract]2023 Jan 25;14(1):399. PMID: 36693889 -
ACS Nano
2023 Dec 12;17(23):23872-23888. PMID: 38084420 -
J Adv Res
Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice. [Abstract]2023 Oct:52:89-102. PMID: 36996967 -
Sci Immunol
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation. [Abstract]2022 Feb 4;7(68):eabk2092. PMID: 35119941 -
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Redox Biol
8-oxo-7,8-dihydroguanosine (8-oxo-Guo) drives pulmonary inflammatory pathways through pattern recognition receptors. [Abstract]2026 May 14:94:104211. PMID: 42190561 -
Redox Biol
Inhibition of NLRP3-mediated crosstalk between hepatocytes and liver macrophages by geniposidic acid alleviates cholestatic liver inflammatory injury. [Abstract]2022 Sep:55:102404. PMID: 35868156 -
Redox Biol
NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy. [Abstract]2020 Jul:34:101523. PMID: 32273259 -
Redox Biol
PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. [Abstract]2019 Sep:26:101254. PMID: 31229841 -
Sci Transl Med
Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models. [Abstract]2023 Jan 11;15(678):eabl7895. PMID: 36630483 -
Gut Microbes
Antibiotic cocktail-induced changes in gut microbiota drive alteration of bile acid metabolism to restrain Th17 differentiation through the FXR-NLRP3 axis. [Abstract]2025 Dec 31;17(1):2582944. PMID: 41305918 -
J Clin Invest
Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury. [Abstract]2026 Apr 2;136(12):e196112. PMID: 41926211 -
Adv Sci (Weinh)
Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31. [Abstract]2026 Jun 30:e76393. PMID: 42378650 -
Adv Sci (Weinh)
Generation of Anti-Mastitis Gene-Edited Dairy Goats with Enhancing Lysozyme Expression by Inflammatory Regulatory Sequence using ISDra2-TnpB System. [Abstract]2024 Oct;11(38):e2404408. PMID: 39099401 -
Adv Sci (Weinh)
A Bioinspired Immunostimulatory System for Inducing Powerful Antitumor Immune Function by Directly Causing Plasma Membrane Rupture. [Abstract]2024 May;11(20):e2305934. PMID: 38484186 -
Cell Death Differ
FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. [Abstract]2023 Jan;30(1):168-183. PMID: 36104448 -
Mol Biomed
ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity. [Abstract]2025 Nov 13;6(1):108. PMID: 41231359 -
Mol Biomed
Deleting fibroblast growth factor 2 in macrophages aggravates septic acute lung injury by increasing M1 polarization and inflammatory cytokine secretion. [Abstract]2024 Oct 22;5(1):50. PMID: 39436561 -
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Research (Wash D C)
Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization. [Abstract]2025 Sep 25:2025:0897. PMID: 41019284 -
J Control Release
Reversing immunotherapy resistance in cold tumors by weaponizing pyroptosis with a dual-payload nanotuner. [Abstract]2026 Jun 18:396:115116. PMID: 42314991 -
J Control Release
Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy. [Abstract]2021 Jan 10:329:445-453. PMID: 33285103 -
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Cell Death Dis
Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression. [Abstract]2024 Oct 23;15(10):770. PMID: 39438459 -
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Cell Death Dis
Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection. [Abstract]2023 Apr 21;14(4):282. PMID: 37080966 -
Cell Death Dis
HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome. [Abstract]2023 Mar 17;14(3):200. PMID: 36928344 -
Cell Death Dis
Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis. [Abstract]2023 Mar 1;14(3):174. PMID: 36859530 -
Cell Death Dis
Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages. [Abstract]2022 Apr 19;13(4):372. PMID: 35440074 -
Pharmacol Res
2022 Apr:178:106143. PMID: 35219871 -
Cell Death Dis
Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease. [Abstract]2022 Mar 30;13(3):283. PMID: 35354793 -
Cell Death Dis
Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction. [Abstract]2022 Mar 29;13(3):281. PMID: 35351877 -
Pharmacol Res
Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases. [Abstract]2021 Feb:164:105384. PMID: 33352229 -
Cell Death Dis
Rosuvastatin protects against coronary microembolization-induced cardiac injury via inhibiting NLRP3 inflammasome activation. [Abstract]2021 Jan 12;12(1):78. PMID: 33436548 -
Cell Death Dis
Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype. [Abstract]2020 May 15;11(5):377. PMID: 32415059 -
Cell Death Dis
Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. [Abstract]2018 Sep 20;9(10):946. PMID: 30237538
MCC950 sodium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Sep 20;9(10):946. [Abstract]
The efficiency of MCC950, and its effect on caspase-1 activation and IL-1β production in As2O3-treated HepG2 cells.
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Cell Death Dis
Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury. [Abstract]2017 Nov 16;8(11):e3170. PMID: 29144508 -
Small
Alpha-Emitter Radium-223 Induces STING-Dependent Pyroptosis to Trigger Robust Antitumor Immunity. [Abstract]2024 Mar;20(9):e2307448. PMID: 37845027 -
Cancer Lett
NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma. [Abstract]2021 Jan 28:497:178-189. PMID: 33091534 -
Int J Biol Sci
ANXA6 Overexpression Causes Abnormal Decidual Macrophage-Trophoblast Crosstalk in Recurrent Spontaneous Abortion. [Abstract]2025 Aug 11;21(12):5206-5222. PMID: 40959268 -
Int J Biol Sci
Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy. [Abstract]2024 Apr 29;20(7):2658-2685. PMID: 38725851 -
Int J Biol Sci
2023 Jan 16;19(3):936-949. PMID: 36778113 -
J Allergy Clin Immunol
IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP. [Abstract]2022 Aug;150(2):337-351. PMID: 35346673 -
Int J Biol Sci
The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration. [Abstract]2022 Jan 1;18(2):809-825. PMID: 35002527 -
Cell Commun Signal
NLRP3-mediated epithelial pyroptosis involved in airway hyperresponsiveness in combined eosinophilic and neutrophilic asthma. [Abstract]2026 Jan 31;24(1):144. PMID: 41620621 -
Cell Commun Signal
Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation. [Abstract]2023 May 25;21(1):123. PMID: 37231437 -
J Neuroinflammation
Herpes simplex virus 1 accelerates the progression of Alzheimer's disease by modulating microglial phagocytosis and activating NLRP3 pathway. [Abstract]2024 Jul 18;21(1):176. PMID: 39026249 -
J Neuroinflammation
NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels. [Abstract]2022 Jun 21;19(1):163. PMID: 35729645 -
J Neuroinflammation
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome. [Abstract]2022 Jun 6;19(1):133. PMID: 35668454 -
J Neuroinflammation
Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats. [Abstract]2021 Oct 19;18(1):239. PMID: 34666787 -
J Neuroinflammation
Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice. [Abstract]2021 Jun 24;18(1):142. PMID: 34162415 -
J Neuroinflammation
NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury. [Abstract]2020 Jul 23;17(1):219. PMID: 32703306 -
J Neuroinflammation
Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats. [Abstract]2018 Mar 24;15(1):95. PMID: 29573749
MCC950 sodium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2018 Mar 24;15(1):95. [Abstract]
Chronic PVN infusion of MCC950 significantly decreases apoptosis-associated speck-like protein (ASC), pro-caspase-1, and IL-1β expression in high-salt diet rats.
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Phytomedicine
2026 Jun 17:159:158448. PMID: 42364560 -
Phytomedicine
GSTM2 as the molecular linking of depression-driven colon cancer progression and chemoresistance: Reversal by Sinisan. [Abstract]2026 Jun:155:158113. PMID: 41962265 -
Phytomedicine
Pterostilbene mitigates scopolamine-induced cognitive impairment by modulating cholinergic pathway and reducing neuroinflammation. [Abstract]2026 Jan:150:157630. PMID: 41353883 -
Phytomedicine
Maiwei Yangfei decoction protects against pulmonary fibrosis by suppressing NLRP3 inflammasome-mediated pyroptosis of alveolar macrophage. [Abstract]2025 Sep:145:157041. PMID: 40652799 -
Phytomedicine
Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3. [Abstract]2025 Jan:136:156260. PMID: 39579610 -
Phytomedicine
Tryptanthrin suppresses multiple inflammasome activation to regulate NASH progression by targeting ASC protein. [Abstract]2024 Aug:131:155758. PMID: 38843643 -
Phytomedicine
Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARα/LACC1/NF-κB signaling pathway. [Abstract]2024 Jan:123:155193. PMID: 37976692 -
Phytomedicine
Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases. [Abstract]2024 Jan:122:155159. PMID: 37931457 -
Phytomedicine
Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis and autophagy. [Abstract]2023 Jul 25:116:154909. PMID: 37269775 -
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Mater Today Bio
Targeted inflammatory microenvironment remodeling and NIR-II photothermal therapy for abdominal aortic aneurysm. [Abstract]2026 Jan 6:36:102770. PMID: 41567736 -
-
Adv Healthc Mater
Dysregulation of Cell Adhesion in Epidermal Stem Cells of Prurigo Nodularis Reduces Their Proliferative Capacity. [Abstract]2025 Dec 17:e04017. PMID: 41409010 -
-
J Hazard Mater
NLRP3 inflammasome mediates pyroptosis of alveolar macrophages to induce radiation lung injury. [Abstract]2025 Feb 15:484:136740. PMID: 39642726 -
J Hazard Mater
2020 Nov 15:399:123034. PMID: 32544768 -
Acta Pharmacol Sin
Microglial STING activation promotes neuroinflammation and pathological changes in experimental mice with intracerebral haemorrhage. [Abstract]2025 Apr 8. PMID: 40200123 -
Cell Death Discov
IP3R2-mediated Ca2+ release promotes LPS-induced cardiomyocyte pyroptosis via the activation of NLRP3/Caspase-1/GSDMD pathway. [Abstract]2024 Feb 20;10(1):91. PMID: 38378646 -
Cell Death Discov
Coal dust nanoparticles induced pulmonary fibrosis by promoting inflammation and epithelial-mesenchymal transition via the NF-κB/NLRP3 pathway driven by IGF1/ROS-mediated AKT/GSK3β signals. [Abstract]2022 Dec 29;8(1):500. PMID: 36581638 -
Acta Pharmacol Sin
2022 Apr;43(4):992-1000. PMID: 34341510 -
Acta Pharmacol Sin
Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation. [Abstract]2021 Dec;42(12):2016-2032. PMID: 34226664 -
J Cachexia Sarcopenia Muscle
MCC950-Loaded M12-Liposome Nanoparticles for Targeted Inhibition of NLRP3 Inflammasome in Sepsis-Induced Muscle Atrophy. [Abstract]2026 Apr;17(2):e70285. PMID: 41983452 -
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J Orthop Translat
SHP2-mediated ROS activation induces chondrocyte paraptosis in osteoarthritis and is attenuated by low-intensity pulsed ultrasound. [Abstract]2025 Apr 25:52:233-248. PMID: 40337549 -
J Transl Med
L-Fucose alleviates inflammation, pyroptosis and mitochondrial injury in obesity-related cardiac injury via TLR4/MyD88/NF-κB pathway. [Abstract]2025 Dec 8;23(1):1385. PMID: 41361467 -
J Transl Med
Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease. [Abstract]2025 Jun 5;23(1):631. PMID: 40474178 -
J Transl Med
Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights. [Abstract]2024 Feb 15;22(1):155. PMID: 38360728 -
J Transl Med
C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome. [Abstract]2023 Dec 11;21(1):904. PMID: 38082306 -
Proc Natl Acad Sci U S A
Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis. [Abstract]2025 Dec 9;122(49):e2515641122. PMID: 41348733 -
Proc Natl Acad Sci U S A
Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages. [Abstract]2024 Aug 13;121(33):e2406492121. PMID: 39361877 -
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Osteoarthritis Cartilage
2024 Aug;32(8):921-937. PMID: 38719085 -
Basic Res Cardiol
Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis. [Abstract]2022 Aug 23;117(1):40. PMID: 35997820 -
Oncogene
Targeting TFAM downregulation mediated mtDNA-NLRP3 pathway suppresses TAM infiltration and HCC progression. [Abstract]2025 Sep;44(33):2956-2969. PMID: 40517169 -
Apoptosis
AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure. [Abstract]2025 Jul 23. PMID: 40702248 -
Apoptosis
The gut microbial metabolite phenylacetylglutamine increases susceptibility to atrial fibrillation after myocardial infarction through ferroptosis and NLRP3 inflammasome. [Abstract]2024 Dec 3. PMID: 39627575 -
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Int J Nanomedicine
Scutellaria baicalensis-Derived Extracellular Vesicles Alleviate Inflammatory Bowel Disease by Inhibiting the NF-κB/NLRP3 Pathway. [Abstract]2026 Apr 27:21:586382. PMID: 42079434 -
Int J Biol Macromol
Glutathion peroxidase 4 (GPX4) and Ribosomal Protein L40 (RPL40) participate in arsenic induced progression of renal cell carcinoma by regulating the NLRP3 mediated classic pyroptosis pathway. [Abstract]2025 May;310(Pt 2):143129. PMID: 40239794 -
Int J Biol Macromol
Serine protease Rv2569c inhibits inflammatory response and promotes intracellular survival of Mycobacterium tuberculosis by targeting the RhoG-NF-κB-NLRP3 pathway. [Abstract]2025 May;309(Pt 4):143022. PMID: 40228763 -
Int J Nanomedicine
Apelin-13-Loaded Macrophage Membrane-Encapsulated Nanoparticles for Targeted Ischemic Stroke Therapy via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis. [Abstract]2024 Sep 7:19:9175-9193. PMID: 39263632 -
Microbiol Res
Caspase-4/11-mediated non-canonical pyroptosis disrupts blood-brain barrier integrity via VEGFA/VEGFR2 signaling in Escherichia coli meningitis. [Abstract]2026 Aug:309:128531. PMID: 42034039 -
Int J Mol Med
Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway. [Abstract]2026 Jul;58(1):187. PMID: 42138188 -
Int J Mol Med
Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling. [Abstract]2026 Apr;57(4):85. PMID: 41645764 -
Neural Regen Res
Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss. [Abstract]2025 Oct 1;20(10):3025-3039. PMID: 39610108 -
Neural Regen Res
MCC950 suppresses NLRP3-dependent neuroinflammation and ameliorates cognitive decline in a rat model of cerebral small vessel disease. [Abstract]2025 Jun 19. PMID: 40537012 -
Int J Mol Med
Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages. [Abstract]2023 Apr;51(4):32. PMID: 36896789 -
Int J Mol Med
Silencing of miR‑155 suppresses inflammatory responses in psoriasis through inflammasome NLRP3 regulation. [Abstract]2018 Aug;42(2):1086-1095. PMID: 29767259 -
EMBO J
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11. [Abstract]2025 Aug;44(16):4419-4442. PMID: 40670771 -
EMBO J
2022 Oct 17;e111173. PMID: 36245295
MCC950 sodium purchased from MedChemExpress. Usage Cited in: EMBO J. 2022 Oct 17;e111173. [Abstract]
BMDMs isolated from Phb1F/F mice and Phb1MyeKO mice are incubated with MCC950 (50 nM) for 30 min and are subsequently stimulated by LPS (200 ng/ml) for 6 h and ATP (4 mM) for 45 min. Protein levels in whole cell lysates and culture medium are detected by WB assay.
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Mol Med
ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway. [Abstract]2025 Apr 7;31(1):131. PMID: 40197211 -
Cell Mol Gastroenterol Hepatol
Kupffer Cell-Derived Exosomal S100A8/A9 Promotes Inflammasome-Dependent Pyroptotic Lung Injury in Acute Pancreatitis. [Abstract]2026 May 12:101810. PMID: 42128052 -
Antioxidants (Basel)
Ginsenoside Rg1 Alleviates Blood-Milk Barrier Disruption in Subclinical Bovine Mastitis by Regulating Oxidative Stress-Induced Excessive Autophagy. [Abstract]2024 Nov 24;13(12):1446. PMID: 39765775 -
Antioxidants (Basel)
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Ameliorate Aging-Induced BTB Impairment in Porcine Testes by Activating Autophagy and Inhibiting ROS/NLRP3 Inflammasomes via the AMPK/mTOR Signaling Pathway. [Abstract]2024 Jan 31;13(2):183. PMID: 38397781 -
Phytother Res
Malvidin-3-O-Rhamnoside Alleviates Klebsiella pneumoniae-Induced Acute Lung Injury by Regulating Macrophage-Mediated Inflammatory and Oxidative Pathways. [Abstract]2026 Jun 14. PMID: 42290103 -
Phytother Res
Berberine Ameliorates Atrial Remodeling and Inhibits the Atrial Fibrillation of Mice via Regulating NLRP3 Inflammasome. [Abstract]2025 Jul 26. PMID: 40716066 -
Phytother Res
Emodin Promotes Peripheral Nerve Repair by Modulating Inflammasome Activation Through Autophagy via the EGFR/PI3K/AKT/mTOR Pathway. [Abstract]2025 Mar 26. PMID: 40135386 -
Phytother Res
Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap. [Abstract]2024 May;38(5):2539-2559. PMID: 38459660 -
Free Radic Biol Med
Forchlorfenuron exposure induces cardiotoxicity via NF-κB/NLRP3-mediated inflammasome activation independent of Septin2 inhibition. [Abstract]2025 Dec 16:244:348-366. PMID: 41412525 -
Free Radic Biol Med
Lipotoxicity-induced upregulation of FIS1 exacerbates mitochondrial fragmentation and promotes NLRP3-dependent pyroptosis in diabetic cardiomyopathy. [Abstract]2025 Feb 16:228:183-196. PMID: 39734056 -
Free Radic Biol Med
Inhibition of the NLRP3/caspase-1 cascade related pyroptosis relieved propofol-induced neuroinflammation and cognitive impairment in developing rats. [Abstract]2024 Nov 20:225:87-97. PMID: 39341300 -
Free Radic Biol Med
Mitochondrial GRIM-19 loss in parietal cells promotes spasmolytic polypeptide-expressing metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS) -NRF2- Heme oxygenase-1(HO-1)-NF-кB axis. [Abstract]2023 Mar 27;202:46-61. PMID: 36990300 -
Free Radic Biol Med
Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis. [Abstract]2021 Sep:173:29-40. PMID: 34246777 -
Clin Transl Med
ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury. [Abstract]2025 Apr;15(4):e70289. PMID: 40211890 -
Clin Transl Med
Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions. [Abstract]2024 Apr;14(4):e1653. PMID: 38616702 -
Clin Transl Med
Translocation of gasdermin D induced mitochondrial injury and mitophagy mediated quality control in lipopolysaccharide related cardiomyocyte injury. [Abstract]2022 Aug;12(8):e1002. PMID: 36030524 -
Am J Chin Med
Rhein Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting the Microglial NLRP3 Inflammasome/Pyroptosis Axis and Regulating Microglial M1/M2 Phenotypes. [Abstract]2026;54(1):263-284. PMID: 41684092 -
Aging Cell
Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway. [Abstract]2025 Jul;24(7):e70061. PMID: 40192010 -
Cell Rep
The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis. [Abstract]2025 Jul 26;44(8):116076. PMID: 40716062 -
Cell Rep
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA. [Abstract]2025 Jun 13;44(6):115851. PMID: 40516055 -
Cell Rep
Myeloid-lineage-specific membrane protein LRRC25 suppresses immunity in solid tumor and is a potential cancer immunotherapy checkpoint target. [Abstract]2025 Apr 24;44(5):115631. PMID: 40279244 -
Cell Rep
2024 Sep 26;43(10):114788. PMID: 39340778 -
Aging Cell
Age-dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution. [Abstract]2023 May;22(5):e13811. PMID: 36999514 -
Cell Rep
Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome. [Abstract]2023 Feb 16;42(2):112133. PMID: 36800288 -
Neuropsychopharmacology
Enduring glucocorticoid-evoked exacerbation of synaptic plasticity disruption in male rats modelling early Alzheimer's disease amyloidosis. [Abstract]2021 Nov;46(12):2170-2179. PMID: 34188184 -
Cell Prolif
NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation. [Abstract]2021 Feb;54(2):e12973. PMID: 33382502 -
Br J Pharmacol
The deubiquitinase YOD1 in cardiomyocytes mediates septic cardiomyopathy by deubiquitinating and thus stabilizing the NLRP3 inflammasome. [Abstract]2026 Jul;183(13):3558-3577. PMID: 41913386 -
Brain Behav Immun
Remifentanil-induced inflammation in microglial cells: Activation of the PAK4-mediated NF-κB/NLRP3 pathway and onset of hyperalgesia. [Abstract]2025 Jan:123:334-352. PMID: 39322089 -
Br J Pharmacol
Cerebroprotection by dioscin after experimental subarachnoid haemorrhage via inhibiting NLRP3 inflammasome through SIRT1-dependent pathway. [Abstract]2021 Sep;178(18):3648-3666. PMID: 33904167 -
Chin Med
Dachaihu decoction alleviates septic liver injury by modulating the intestinal barrier dysfunction and suppressing the NF-κB/NLRP3/Caspase-1 signaling pathway. [Abstract]2026 Jun 16;21(1):168. PMID: 42298689 -
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J Med Chem
Deep-Learning-Driven Discovery of SN3-1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases. [Abstract]2024 Oct 10;67(19):17833-17854. PMID: 39302813 -
Atherosclerosis
Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice. [Abstract]2019 Oct:289:132-142. PMID: 31513948 -
J Invest Dermatol
Advanced Glycation End Products Promote Melanogenesis by Activating NLRP3 Inflammasome in Human Dermal Fibroblasts. [Abstract]2022 Oct;142(10):2591-2602.e8. PMID: 35421403 -
Front Immunol
The Increase in IL-1β in the Early Stage of Heatstroke Might Be Caused by Splenic Lymphocyte Pyroptosis Induced by mtROS-Mediated Activation of the NLRP3 Inflammasome. [Abstract]2019 Dec 11:10:2862. PMID: 31921131 -
Emerg Microbes Infect
Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway. [Abstract]2018 Jan 10;7(1):1. PMID: 29323102 -
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J Ethnopharmacol
Danggui-Shaoyao-San ameliorates metabolic dysfunction-associated steatohepatitis via suppressing hepatic macrophage NLRP3 inflammasome. [Abstract]2026 Jul 15:366:121578. PMID: 41905728 -
J Ethnopharmacol
Didymin alleviates neuropathic pain by targeting RKIP-mediated NF-κB/NLRP3 crosstalk to inhibit pyroptosis and neuroinflammation. [Abstract]2026 Mar 25:359:121046. PMID: 41453551 -
J Ethnopharmacol
Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition of pyroptosis. [Abstract]2026 Apr 6:360:121209. PMID: 41539636 -
J Ethnopharmacol
Ginsenoside Rg1 improves chronic neuropathic pain by inhibiting NLRP3 inflammasome activation and cell pyroptosis in microglia. [Abstract]2025 Jul 30;353(Pt A):120346. PMID: 40750033 -
J Ethnopharmacol
Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome. [Abstract]2025 Jan 10:336:118661. PMID: 39159837 -
J Ethnopharmacol
Octahydroindolizine alkaloid Homocrepidine A from Dendrobium crepidatum attenuate P. acnes-induced inflammatory in vitro and in vivo. [Abstract]2024 Oct 28:333:118455. PMID: 38871011 -
J Ethnopharmacol
Xiaoqinglong decoction improves allergic rhinitis by inhibiting NLRP3-mediated pyroptosis in BALB/C mice. [Abstract]2024 Mar 1:321:117490. PMID: 38030025 -
J Ethnopharmacol
Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome. [Abstract]2023 Dec 5:317:116777. PMID: 37311502 -
J Ethnopharmacol
Polydatin protects against atherosclerosis by activating autophagy and inhibiting pyroptosis mediated by the NLRP3 inflammasome. [Abstract]2023 Jun 12:309:116304. PMID: 36870461 -
Virulence
A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner. [Abstract]2022 Dec;13(1):1486-1501. PMID: 36040120 -
J Agric Food Chem
Chronic Arsenic Exposure Induces Neuroinflammation by Regulating the Nrf2/NLRP3 Inflammasome Signaling Pathway. [Abstract]2025 Dec 17;73(50):31853-31864. PMID: 41353618 -
J Agric Food Chem
Natural Dietary Flavonoid Apigenin Mitigates Ulcerative Colitis via Modulating the AMPK/NF-κB/NLRP3 Signaling Axis. [Abstract]2025 Dec 22. PMID: 41428381 -
J Agric Food Chem
Curcumin Alleviates Bisphenol A-Induced Blood-Testis Barrier Disruption in Mice by Targeting Surfactant Protein B (SFTPB) to Suppress Oxidative Stress-Activated NLRP3 Inflammasome. [Abstract]2025 Nov 19;73(46):29874-29885. PMID: 41212106 -
J Agric Food Chem
β-Hydroxybutyric Acid-Induced Bovine Endometrial Epithelial Cell Pyroptosis via Activating P2X7R. [Abstract]2025 Aug 27;73(34):21296-21308. PMID: 40742321 -
J Agric Food Chem
Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1/TXNIP Signaling Pathway. [Abstract]2025 Jul 2;73(26):16557-16572. PMID: 40552618 -
J Agric Food Chem
3-MCPD Induces Renal Cell Pyroptosis and Inflammation by Inhibiting ESCRT-III-Mediated Cell Repair and Mitophagy. [Abstract]2024 Jun 10. PMID: 38857427 -
J Agric Food Chem
Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway. [Abstract]2023 Aug 30;71(34):12645-12656. PMID: 37585786 -
J Agric Food Chem
Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells. [Abstract]2023 May 10;71(18):7032-7045. PMID: 37141464
MCC950 sodium purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2023 May 10;71(18):7032-7045. [Abstract]
MCC950 (10 μM; 2 h) markedly inhibits the expressionof NLRP3, Cleaved Caspase-1, and Cleaved IL-1β in HUVECs.
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J Agric Food Chem
Eugenol Alleviates TGEV-Induced Intestinal Injury via Suppressing ROS/NLRP3/GSDMD-Dependent Pyroptosis. [Abstract]2023 Jan 25;71(3):1477-1487. PMID: 36642968 -
J Agric Food Chem
Estrogen Receptor α Regulates Metabolic-Associated Fatty Liver Disease by Targeting NLRP3-GSDMD Axis-Mediated Hepatocyte Pyroptosis. [Abstract]2021 Dec 8;69(48):14544-14556. PMID: 34817168 -
J Agric Food Chem
2021 Jul 14;69(27):7755-7764. PMID: 34191510 -
Ecotoxicol Environ Saf
Embryonic exposure to bisphenol A glycidyl methacrylate induces craniofacial cartilage malformation via NLR signaling pathway in zebrafish. [Abstract]2026 May:316:120121. PMID: 41966015 -
Ecotoxicol Environ Saf
Blue light induces corneal epithelial damage by activating the NLRP3 inflammasome pathway. [Abstract]2025 Sep 15:303:118921. PMID: 40850112 -
Ecotoxicol Environ Saf
Co-exposure of microcystin-LR and nitrite induced kidney injury through TLR4/NLRP3/GSDMD-mediated pyroptosis. [Abstract]2024 Aug:281:116629. PMID: 38917587 -
Ecotoxicol Environ Saf
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice. [Abstract]2023 Jan 1:249:114359. PMID: 36508797 -
J Dent Res
2022 Jun;101(6):675-685. PMID: 35050801 -
CNS Neurosci Ther
Electroacupuncture ameliorates postoperative cognitive dysfunction and associated neuroinflammation via NLRP3 signal inhibition in aged mice. [Abstract]2022 Mar;28(3):390-400. PMID: 34951130 -
Ecotoxicol Environ Saf
NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance. [Abstract]2021 Oct 15:223:112590. PMID: 34364127 -
Biochem Pharmacol
Convergence of ER stress and ferroptosis in diabetic vasculopathy: therapeutic protection by ferrostatin-1. [Abstract]2026 Aug;250(Pt 1):117998. PMID: 42025809 -
Biochem Pharmacol
2026 May 14:118065. PMID: 42140447 -
Biochem Pharmacol
Agomir-223 treatment after lung blast injury reduces the inflammatory response by regulating the NLRP3 inflammasome to inhibit M1 macrophage function. [Abstract]2025 Aug 12;242(Pt 1):117220. PMID: 40812582 -
Acta Neuropathol Commun
Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus. [Abstract]2025 Apr 10;13(1):73. PMID: 40205503 -
Biochem Pharmacol
NLRP3 inflammasome activation contributes to the development of the pro-fibrotic phenotype of lung fibroblasts. [Abstract]2024 Nov:229:116496. PMID: 39159876 -
Life Sci
Compressive stress induces cartilage endplate degeneration through the Piezo1/YAP-TEAD/NLRP3 axis. [Abstract]2026 Mar 1:388:124195. PMID: 41506536 -
Life Sci
Exploring the hepatoprotective effects of perillyl alcohol in the experimental models of acute liver injury. [Abstract]2025 Nov 1:380:123926. PMID: 40850494 -
Life Sci
C3aR contributes to unilateral ureteral obstruction-induced renal interstitial fibrosis via the activation of the NLRP3 inflammasome. [Abstract]2022 Nov 1:308:120905. PMID: 36041502 -
Life Sci
Hydrogen sulfide reduces pyroptosis and alleviates ischemia-reperfusion-induced acute kidney injury by inhibiting NLRP3 inflammasome. [Abstract]2021 Nov 1:284:119466. PMID: 33811893 -
Life Sci
Autophagy alleviates mitochondrial DAMP-induced acute lung injury by inhibiting NLRP3 inflammasome. [Abstract]2021 Jan 15:265:118833. PMID: 33275990 -
Life Sci
Rapamycin and MCC950 modified gut microbiota in experimental autoimmune encephalomyelitis mouse by brain gut axis. [Abstract]2020 Jul 15:253:117747. PMID: 32376270 -
Food Funct
Sodium butyrate attenuates experimental neonatal necrotizing enterocolitis by suppressing TLR4-mediated NLRP3 inflammasome-dependent pyroptosis. [Abstract]2025 Apr 14. PMID: 40223745 -
Inflammopharmacology
Paeoniflorin attenuates chronic constriction injury-induced neuropathic pain by suppressing spinal NLRP3 inflammasome activation. [Abstract]2020 Dec;28(6):1495-1508. PMID: 32596762 -
J Neuroimmune Pharmacol
Lamotrigine Ameliorates Epilepsy during Pregnancy in Rats by Inhibiting Astrocyte Activation via the NLRP3/TXNIP Pathway. [Abstract]2026 Jun 3;21(1):27. PMID: 42234255 -
J Clin Transl Hepatol
Mitochondrial GRIM19 Loss Induces Liver Fibrosis through NLRP3/IL33 Activation via Reactive Oxygen Species/NF-кB Signaling. [Abstract]2024 Jun 28;12(6):539-550. PMID: 38974954 -
EMBO Rep
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction. [Abstract]2022 Feb 3;23(2):e53499. PMID: 34882936 -
Neurobiol Dis
TRPM2 contributes to neuroinflammation and cognitive deficits in a cuprizone-induced multiple sclerosis model via NLRP3 inflammasome. [Abstract]2021 Dec:160:105534. PMID: 34673151 -
Neurobiol Dis
Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury. [Abstract]2018 Sep:117:15-27. PMID: 29859317
MCC950 sodium purchased from MedChemExpress. Usage Cited in: Neurobiol Dis. 2018 Sep:117:15-27. [Abstract]
Effect of MCC950 on the expression of NLRP3 inflammasome components and substrates after traumatic brain injury (TBI).
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Neurobiol Dis
NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo. [Abstract]2018 Jun;114:24-30. PMID: 29477641 -
J Am Heart Assoc
Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway. [Abstract]2017 Sep 4;6(9):e006347. PMID: 28871042
MCC950 sodium purchased from MedChemExpress. Usage Cited in: J Am Heart Assoc. 2017 Sep 4;6(9):e006347. [Abstract]
Cells are pretreated with YVAD(10 μM) or MCC950 (10 μM) for 2 hours, and then exposed to TMAO (600 μM) for a further 24 hours. Expression of IL-1β, ICAM-1, MMP-9, and caspase-1 p20 is detected via Western blot.
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Commun Biol
Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration. [Abstract]2025 Jul 29;8(1):1118. PMID: 40731132 -
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J Affect Disord
Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway. [Abstract]2026 Jun 15:403:121439. PMID: 41698615 -
Eur J Pharmacol
Blockade of KCa3.1 ameliorates rheumatoid arthritis by suppressing macrophage M1 polarization via the NLRP3 inflammasome signaling pathway. [Abstract]2026 Mar 28:1019:178738. PMID: 41794275 -
Pharmaceuticals (Basel)
Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Inonotus obliquus Polysaccharide in the Treatment of Rheumatoid Arthritis. [Abstract]2025 Jul 8;18(7):1017. PMID: 40732305 -
Eur J Pharmacol
Targeting the ALKBH5-NLRP3 positive feedback loop alleviates cardiomyocyte pyroptosis after myocardial infarction. [Abstract]2025 Feb 15:989:177247. PMID: 39746531 -
J Gastroenterol
Heparan sulfate acts as an activator of the NLRP3 inflammasome promoting inflammatory response in the development of acute pancreatitis. [Abstract]2024 Sep;59(9):869-879. PMID: 38864913 -
Eur J Pharmacol
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats. [Abstract]2024 Apr 15:969:176428. PMID: 38432572 -
Eur J Pharmacol
Direct inhibition of microglial activation by a μ receptor selective agonist alleviates inflammatory-induced pain hypersensitivity. [Abstract]2023 Dec 15:961:176182. PMID: 37951488 -
Cell Biol Toxicol
AS3MT facilitates NLRP3 inflammasome activation by m6A modification during arsenic-induced hepatic insulin resistance. [Abstract]2023 Oct;39(5):2165-2181. PMID: 35226250 -
J Endocrinol
2023 Feb 16;256(3):e220335. PMID: 36633355 -
Eur J Pharmacol
The selective NLRP3 inflammasome inhibitor MCC950 improves isoproterenol-induced cardiac dysfunction by inhibiting cardiomyocyte senescence. [Abstract]2022 Dec 15:937:175364. PMID: 36336012 -
Biomolecules
Zearalenone Induces Gap Junction Damage in Ovine Ovarian Granulosa Cells by Upregulating GPR30 and Activating the Oxidative Stress-NLRP3 Inflammasome Axis. [Abstract]2026 Jun 7;16(6):837. PMID: 42352304 -
Int Immunopharmacol
Sensory nerve-derived semaphorin 3A promotes bone healing through macrophage immunomodulation. [Abstract]2026 Jun 17:185:117036. PMID: 42308795 -
Int Immunopharmacol
Daphnetin alleviates neuropathic pain in rats by modulating spinal microglial polarization via the Nrf2/NLRP3 inflammasome pathway. [Abstract]2026 Jun 17:185:116986. PMID: 42308799 -
Int Immunopharmacol
2026 May 1:176:116478. PMID: 41825208 -
Int Immunopharmacol
High-cholesterol-load-triggered pyroptosis of gingival fibroblasts promotes periodontitis. [Abstract]2026 Apr 1:174:116259. PMID: 41707588 -
Int Immunopharmacol
IL-5 promotes airway remodeling in asthma by mediating epithelial-mesenchymal transition via the AKT/NLRP3 pathway. [Abstract]2026 Apr 15:175:116422. PMID: 41759267 -
Int Immunopharmacol
Oridonin downregulates PD-L1 expression and promotes anti-tumor immunity via inhibiting NLRP3 and STAT3. [Abstract]2026 Apr 15:175:116423. PMID: 41740339 -
Int Immunopharmacol
α-Methylene-γ-butyrolactone 3 inhibits the activation of NLRP3 inflammasome in sepsis by blocking both the priming and inflammasome assembly. [Abstract]2026 Mar 15:173:116305. PMID: 41628514 -
Int Immunopharmacol
Early P2X7 receptor activation mitigates neonatal group B Streptococcus infection severity and long-term neurodevelopmental impairment. [Abstract]2026 Feb 15:171:116113. PMID: 41475282 -
Int Immunopharmacol
Colistin-induced acute kidney injury via zinc Dyshomeostasis-triggered GSDMD-executed Pyroptosis. [Abstract]2026 Jan 1;168(Pt 1):115768. PMID: 41176907 -
Int Immunopharmacol
Baicalin inhibits Listeria monocytogenes-induced embryonic loss through the JNK/NEK7-NLRP3/GSDMD pathway. [Abstract]2026 Jan 1;168(Pt 2):115921. PMID: 41289943 -
Int Immunopharmacol
STING knockdown blocks disease progression and inflammation in mice with alcoholic liver disease by relieving pyroptosis via suppressing NLRP3. [Abstract]2026 Jan 1;168(Pt 2):115858. PMID: 41265219 -
Int Immunopharmacol
Oridonin alleviates SiNPs-induced pulmonary fibrosis by inhibiting pyroptosis via IRE1α-XBP1s-NLRP3 pathway. [Abstract]2025 Oct 30:164:115388. PMID: 40845545 -
Int Immunopharmacol
Crocin facilitates peripheral nerve regeneration through modulation of the STAT3/Bcl-2/Beclin-1 signaling axis-mediated autophagic pathway. [Abstract]2025 Sep 5:165:115437. PMID: 40913861 -
Int Immunopharmacol
AFB1 exacerbates testicular and intestinal inflammation by increasing stearoyl ethanolamide and homocysteine levels. [Abstract]2025 Jun 26:159:114943. PMID: 40424650 -
Int Immunopharmacol
Mitigating PCOS progression: The protective effect of C-phycocyanin on ovarian granulosa cell pyroptosis via the NRF2/NLRP3/GSDMD pathway. [Abstract]2025 Jun 26:159:114917. PMID: 40412127 -
Int Immunopharmacol
Tetrabromobisphenol S (TBBPS) exposure induced the testicular aging through NLRP3-mediated inflammatory signaling pathway in vitro and in vivo. [Abstract]2025 Apr 16:152:114476. PMID: 40090078 -
Int Immunopharmacol
Long non-coding RNA NRIR inhibits osteogenesis in peri-implantitis by promoting NLRP3 inflammasome-mediated macrophage pyroptosis. [Abstract]2025 Feb 20:148:114180. PMID: 39874847 -
Int J Mol Sci
PCSK9 Enhances Cardiac Fibrogenesis via the Activation of Toll-like Receptor and NLRP3 Inflammasome Signaling. [Abstract]2025 Feb 23;26(5):1921. PMID: 40076547 -
Int Immunopharmacol
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα. [Abstract]2025 Jan 3:145:113781. PMID: 39657538 -
Int Immunopharmacol
The role of lncRNA NEAT1 in acute graft-versus-host disease: Regulation of macrophage polarization and inflammatory cytokine secretion via JNK/NLRP3 pathway. [Abstract]2025 Jan 27:146:113857. PMID: 39721453 -
Int Immunopharmacol
Progesterone suppresses rhinovirus-induced airway inflammation by inhibiting neutrophil infiltration and extracellular traps formation. [Abstract]2025 Jan 10:144:113714. PMID: 39626540 -
Int Immunopharmacol
AdipoRon exerts an antidepressant effect by inhibiting NLRP3 inflammasome activation in microglia via promoting mitophagy. [Abstract]2024 Nov 15:141:113011. PMID: 39213872 -
Int Immunopharmacol
Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson's disease induced by rotenone. [Abstract]2024 Nov 15;143(Pt 3):113608. PMID: 39549548 -
Int Immunopharmacol
MCC950 promotes diabetic wound healing through modulating macrophage polarization in an MDSC-dependent manner. [Abstract]2024 Aug 31;142(Pt A):112983. PMID: 39217887 -
Int Immunopharmacol
Renoprotective effect of rosmarinic acid by inhibition of indoxyl sulfate-induced renal interstitial fibrosis via the NLRP3 inflammasome signaling. [Abstract]2024 Jun 30:135:112314. PMID: 38788450 -
Int Immunopharmacol
Oridonin exerts anticonvulsant profile and neuroprotective activity in epileptic mice by inhibiting NLRP3-mediated pyroptosis. [Abstract]2024 Jun 15:134:112247. PMID: 38759374 -
Int Immunopharmacol
Extracellular ATP contributes to the reactive oxygen species burst and exaggerated mitochondrial damage in D-galactosamine and lipopolysaccharide-induced fulminant hepatitis. [Abstract]2024 Mar 30:130:111680. PMID: 38368772 -
J Hypertens
CTRP3 inhibits myocardial fibrosis through the P2X7R-NLRP3 inflammasome pathway in SHR rats. [Abstract]2024 Feb 1;42(2):315-328. PMID: 37850974 -
Int Immunopharmacol
CXCL5 promotes lipotoxicity of hepatocytes through upregulating NLRP3/Caspase-1/IL-1β signaling in Kupffer cells and exacerbates nonalcoholic steatohepatitis in mice. [Abstract]2023 Oct:123:110752. PMID: 37573690 -
Int Immunopharmacol
GATA6 promotes fibrotic repair of tracheal injury through NLRP3 inflammasome-mediated epithelial pyroptosis. [Abstract]2023 Oct:123:110657. PMID: 37531826 -
Int J Mol Sci
S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NF-κB/NLRP3 Inflammasome Signaling Pathway. [Abstract]2023 Aug 11;24(16):12709. PMID: 37628889 -
Int Immunopharmacol
Pyroptosis of chondrocytes activated by synovial inflammation accelerates TMJ osteoarthritis cartilage degeneration via ROS/NLRP3 signaling. [Abstract]2023 Aug 23;124(Pt A):110781. PMID: 37625369 -
Int J Mol Sci
Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin. [Abstract]2023 Jul 20;24(14):11692. PMID: 37511451 -
Int J Mol Sci
Vitamin A Promotes the Fusion of Autophagolysosomes and Prevents Excessive Inflammasome Activation in Dextran Sulfate Sodium-Induced Colitis. [Abstract]2023 May 12;24(10):8684. PMID: 37240022 -
Int Immunopharmacol
Sustained activation of NLRP3 inflammasome contributes to delayed wound healing in aged mice. [Abstract]2023 Mar:116:109828. PMID: 36774855 -
Int J Mol Sci
Hyperglycemia Aggravates Periodontitis via Autophagy Impairment and ROS-Inflammasome-Mediated Macrophage Pyroptosis. [Abstract]2023 Mar 27;24(7):6309. PMID: 37047282
MCC950 sodium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Mar 27;24(7):6309. [Abstract]
MCC950 (5 μM; every other day for four weeks) significantly decreases CD68+ and GSDMD+ cells in rats.
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Int Immunopharmacol
Trophoblastic mitochondrial DNA induces endothelial dysfunction and NLRP3 inflammasome activation: Implications for preeclampsia. [Abstract]2023 Jan:114:109523. PMID: 36508916 -
Int Immunopharmacol
Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis by the NOX2/NLRP3 inflammasome signaling pathway. [Abstract]2022 Dec;113(Pt A):109321. PMID: 36252479 -
Int Immunopharmacol
Co-activation of Caspase-1 and Caspase-8 in CMV-induced SGN death by inflammasome-associated pyroptosis and apoptosis. [Abstract]2022 Dec;113(Pt A):109305. PMID: 36244217 -
Int J Mol Sci
Blockage of KHSRP-NLRP3 by MCC950 Can Reverse the Effect of Manganese-Induced Neuroinflammation in N2a Cells and Rat Brain. [Abstract]2022 Oct 30;23(21):13224. PMID: 36362011 -
Int Immunopharmacol
Activation of NLRP3 inflammasome contributes to the inflammatory response to allergic rhinitis via macrophage pyroptosis. [Abstract]2022 Sep:110:109012. PMID: 35809382 -
Int Immunopharmacol
Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury. [Abstract]2021 Mar:92:107352. PMID: 33422760 -
Mol Neurobiol
NLRP3 Inflammasome Activation Contributes to Seizure Susceptibility in Anti-NMDAR Encephalitis: Evidence from Patients and a Mouse Model. [Abstract]2025 Nov 11;63(1):25. PMID: 41217696 -
Mol Neurobiol
PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis. [Abstract]2025 Jul 19. PMID: 40682720 -
Mol Neurobiol
Huang-Pu-Tong-Qiao Formula Alleviates Hippocampal Neuron Damage by Inhibiting NLRP3 Inflammasome-mediated Pyroptosis in Alzheimer's Disease. [Abstract]2025 Apr;62(4):4545-4561. PMID: 39466576 -
Invest Ophthalmol Vis Sci
Involvement of cGAS/STING Signaling in the Pathogenesis of Candida albicans Keratitis: Insights From Genetic and Pharmacological Approaches. [Abstract]2024 Jun 3;65(6):13. PMID: 38848078 -
Mol Neurobiol
Inhibiting the NLRP3 Inflammasome with MCC950 Alleviates Neurological Impairment in the Brain of EAE Mice. [Abstract]2024 Mar;61(3):1318-1330. PMID: 37702910 -
Invest Ophthalmol Vis Sci
SIRT1 Inhibits High Glucose-Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation. [Abstract]2023 Mar 1;64(3):16. PMID: 36881408 -
Invest Ophthalmol Vis Sci
The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-β1 Expression in the Corneal Epithelium. [Abstract]2022 Jul 8;63(8):15. PMID: 35838447 -
Inflammation
Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling. [Abstract]2025 Dec 20;49(1):11. PMID: 41420798 -
Immunology
TIM3/CEACAM1 pathway involves in myeloid-derived suppressor cells induced CD8+ T cells exhaustion and bone marrow inflammatory microenvironment in myelodysplastic syndrome. [Abstract]2023 Feb;168(2):273-289. PMID: 35470423 -
Front Pharmacol
Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro. [Abstract]2022 Jul 5:13:906548. PMID: 35865939 -
Front Pharmacol
Pharmacological Basis for Use of a Novel Compound in Hyperuricemia: Anti-Hyperuricemic and Anti-Inflammatory Effects. [Abstract]2021 Nov 8:12:772504. PMID: 34819865 -
Immunology
NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl- concentration. [Abstract]2021 Aug;163(4):493-511. PMID: 33835494 -
Front Pharmacol
Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling. [Abstract]2021 Jul 15:12:667644. PMID: 34335245 -
Front Pharmacol
Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis. [Abstract]2020 Mar 31:11:200. PMID: 32296329 -
Probiotics Antimicrob Proteins
Bifidobacterium breve BBr60 Enhances SCFA Levels and Restores NLRP3/NLRP6 Balance in the Gut to Improve Motor Deficits in PD Mice. [Abstract]2025 Jun 6. PMID: 40478433 -
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Front Cell Dev Biol
Long Non-coding RNA MEG3 Promotes Pyroptosis in Testicular Ischemia-Reperfusion Injury by Targeting MiR-29a to Modulate PTEN Expression. [Abstract]2021 Jun 18:9:671613. PMID: 34222244 -
Front Cell Dev Biol
Targeting TFE3 Protects Against Lysosomal Malfunction-Induced Pyroptosis in Random Skin Flaps via ROS Elimination. [Abstract]2021 Apr 8:9:643996. PMID: 33898433 -
Int Dent J
Chemerin Promotes Oral Squamous Cell Carcinoma Progression via NLRP3-Mediated Pyroptosis and the GSDMD-N Pathway. [Abstract]2026 Apr 9;76(3):109541. PMID: 41962510 -
Chem Biol Interact
Cytochrome P450-mediated detoxification and NF-κB/NLRP3 pathway-driven hepatotoxicity of emodin: Multiomics and laboratory evidence. [Abstract]2026 Mar 25:427:111934. PMID: 41579920 -
Toxicology
PM2.5 exposure exacerbates airway pyroptosis related inflammatory response in asthmatic mice by activating NLRP3 inflammasome. [Abstract]2025 Dec 18:521:154376. PMID: 41421518 -
Chem Biol Interact
Decabromodiphenyl ether (BDE-209) induces learning and memory impairment via JAK2/STAT3/NLRP3 axis-mediated pyroptosis and neuroinflammation. [Abstract]2025 Oct 8:419:111665. PMID: 40675405 -
Int Dent J
Inhibition of Dynamin-Related Protein 1-Dependent Mitochondrial Fission Ameliorates Apical Periodontitis by Attenuating NLRP3 Inflammasome-Mediated M1 Macrophage Polarisation. [Abstract]2025 Jun 14;75(4):100853. PMID: 40517458 -
J Nutr Biochem
Genistein upregulates AHR to protect against environmental toxin-induced NASH by inhibiting NLRP3 inflammasome activation and reconstructing antioxidant defense mechanisms. [Abstract]2023 Nov:121:109436. PMID: 37666477 -
Chem Biol Interact
S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome. [Abstract]2023 Aug 1:380:110541. PMID: 37169277 -
Toxicology
Zearalenone induces NLRP3-dependent pyroptosis via activation of NF-κB modulated by autophagy in INS-1 cells. [Abstract]2019 Dec 1:428:152304. PMID: 31586597 -
Biofactors
Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells. [Abstract]2018 Mar;44(2):123-136. PMID: 29193391
MCC950 sodium purchased from MedChemExpress. Usage Cited in: Biofactors. 2018 Mar;44(2):123-136. [Abstract]
NLRP3, Casp1 p20, IL-1b, and ICAM-1 protein levels are assessed in the cell lysates by Western blotting.
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Bioorg Chem
Aucubin attenuates neonatal hypoxic-ischemic brain injury by suppressing NLRP3 inflammasome-mediated microglial pyroptosis. [Abstract]2026 Jan:168:109332. PMID: 41365065 -
Molecules
Constituents from Dolichos lablab L. Flowers and Their Anti-Inflammatory Effects via Inhibition of IL-1β Release. [Abstract]2024 Aug 7;29(16):3751. PMID: 39202831 -
Molecules
MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise. [Abstract]2024 Feb 4;29(3):712. PMID: 38338456 -
Molecules
Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome. [Abstract]2023 Apr 29;28(9):3817. PMID: 37175227 -
Molecules
Downregulation of the NLRP3/Caspse-1 Pathway Ameliorates Ketamine-Induced Liver Injury and Inflammation in Developing Rats. [Abstract]2022 May 4;27(9):2931. PMID: 35566282 -
Molecules
Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. [Abstract]2018 Feb 27;23(3):522. PMID: 29495433
MCC950 sodium purchased from MedChemExpress. Usage Cited in: Molecules. 2018 Feb 27;23(3):522. [Abstract]
Effects of MCC950 on hippocampal NLRP3 inflammasome activation in db/db mice. Western blot analysis of NLRP3 inflammasome-associated NLRP3, ASC, IL-1β, and β-actin are performed in the hippocampus of each group.
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Biochim Biophys Acta Mol Basis Dis
PLUNC inhibits invasion and metastasis in nasopharyngeal carcinoma by inhibiting NLRP3 inflammasome activation. [Abstract]2024 Oct;1870(7):167352. PMID: 39004379 -
Mol Med Rep
Dapagliflozin alleviates renal podocyte pyroptosis via regulation of the HO‑1/NLRP3 axis. [Abstract]2023 Nov;28(5):200. PMID: 37711056 -
Biochim Biophys Acta Mol Basis Dis
The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation. [Abstract]2018 Jan;1864(1):1-10. PMID: 28986310
MCC950 sodium purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):1-10. [Abstract]
MCC950 or vehicle control (PBS) is administered at 1, 4 and 6 day after Ang II infusion in the absence or presence of EMD638683. Representative images and quantification of picrosirius red-stained collagen in the heart at 7 days after Ang II infusion.
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Biochim Biophys Acta Mol Basis Dis
A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation. [Abstract]2017 Jun;1863(6):1556-1567. PMID: 28216285 -
PLoS Pathog
African swine fever virus pEP364R acts as an important inflammatory-inducing factor to activate NLRP3 inflammasome-mediated pyroptosis by regulating DDX3X. [Abstract]2026 Feb 25;22(2):e1013874. PMID: 41739885 -
Sci Rep
I-BET151 modulates NLRP3 inflammasome-mediated pyroptosis and exhibits anti-inflammatory activity. [Abstract]2025 Dec 3;16(1):994. PMID: 41339462 -
Sci Rep
2025 Sep 23;15(1):32637. PMID: 40987781 -
Sci Rep
HIIT and MICT mitigate endothelial dysfunction in early atherosclerotic mice via PCSK9 inhibition. [Abstract]2025 Aug 19;15(1):30411. PMID: 40830352 -
Sci Rep
The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury. [Abstract]2025 Jul 2;15(1):22990. PMID: 40594884 -
Sci Rep
RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells. [Abstract]2025 Jul 1;15(1):21294. PMID: 40595708 -
Toxics
Mechanistic Studies on the Role of IL-17/NLRP3 in Arsenic-Induced Activation of Hepatic Stellate Cells Through Hepatocyte Proptosis. [Abstract]2025 Apr 9;13(4):287. PMID: 40278603 -
Sci Rep
Ocifisertib alleviates the gasdermin D-independent pyroptosis of nucleus pulposus cells by targeting GSDME. [Abstract]2025 Apr 17;15(1):13280. PMID: 40247083 -
Sci Rep
S100 calcium-binding protein A8 exacerbates deep vein thrombosis in vascular endothelial cells. [Abstract]2025 Jan 4;15(1):831. PMID: 39755911 -
Mediators Inflamm
Cryptotanshinone Inhibits Bladder Cancer Cell Malignant Progression in a Lipopolysaccharide-Induced Inflammatory Microenvironment through NLRP3 Inhibition. [Abstract]2024 Jan 30:2024:8828367. PMID: 39144184 -
Toxics
Ginsenoside Rg1 Mitigates Porcine Intestinal Tight Junction Disruptions Induced by LPS through the p38 MAPK/ NLRP3 Inflammasome Pathway. [Abstract]2022 May 27;10(6):285. PMID: 35736894 -
Exp Neurol
Inhibiting the IRAK4/NF-κB/NLRP3 signaling pathway can reduce pyroptosis in hippocampal neurons and seizure episodes in epilepsy. [Abstract]2024 Jul:377:114794. PMID: 38685307 -
Exp Neurol
Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice. [Abstract]2024 Jan:371:114586. PMID: 37898396 -
Int J Neuropsychopharmacol
Albiflorin Attenuates Mood Disorders Under Neuropathic Pain State by Suppressing the Hippocampal NLRP3 Inflammasome Activation During Chronic Constriction Injury. [Abstract]2021 Jan 20;24(1):64-76. PMID: 33000169 -
Curr Res Toxicol
The NLRP3 inhibitor, MCC950, attenuates environmental pollutant PM2.5-induced acute lung injury by inhibiting alveolar macrophage pyroptosis. [Abstract]2026 Jan 22:10:100282. PMID: 41743188 -
J Cell Mol Med
2025 Oct;29(19):e70802. PMID: 41078093 -
Cell Signal
Rescuing fertility: Itaconic acid prevents ovarian damage through NRF2-mediated pyroptosis pathways in diminished ovarian reserve models. [Abstract]2025 Jul:131:111766. PMID: 40147551 -
Microorganisms
Lactobacillus johnsonii L531 Alleviates the Damage Caused by Salmonella Typhimurium via Inhibiting TLR4, NF-κB, and NLRP3 Inflammasome Signaling Pathways. [Abstract]2021 Sep 17;9(9):1983. PMID: 34576878 -
J Inflamm Res
IL-17RA Promotes Cigarette Smoke-Induced Alveolar Epithelial Cell Pyroptosis in COPD via Dual Activation of the NLRP3/Caspase1/GSDMD and NF-κB/GSDME Pathways. [Abstract]2026 Jun 18:19:578571. PMID: 42339301 -
J Inflamm Res
MCC950 Alleviates Experimental Autoimmune Neuritis by Inhibiting NLRP3 Inflammasome Activity and Down-Regulating Interleukin-23/Interleukin-17 Axis Expression. [Abstract]2025 Dec 6:18:17113-17127. PMID: 41394901 -
J Inflamm Res
Cigarette Smoking Induces Skeletal Muscle Atrophy in Mice by Activated Macrophage-Mediated Pyroptosis. [Abstract]2025 Feb 19:18:2447-2464. PMID: 39991657 -
Aquat Toxicol
Perfluorooctane sulfonate causes pyroptosis and lipid metabolism disorders through ROS-mediated NLRP3 inflammasome activation in grass carp hepatocyte. [Abstract]2024 Feb:267:106839. PMID: 38228041 -
J Inflamm Res
Neutrophil Extracellular Traps Induce Alveolar Macrophage Pyroptosis by Regulating NLRP3 Deubiquitination, Aggravating the Development of Septic Lung Injury. [Abstract]2023 Feb 27:16:861-877. PMID: 36876152 -
Environ Toxicol Pharmacol
Annexin A1 inhibition facilitates NLRP3 inflammasome activation in arsenic-induced insulin resistance in rat liver. [Abstract]2022 Nov:96:103981. PMID: 36182042 -
J Inflamm Res
Regulation of the Immune Microenvironment by an NLRP3 Inhibitor Contributes to Attenuation of Acute Right Ventricular Failure in Rats with Pulmonary Arterial Hypertension. [Abstract]2021 Nov 2;14:5699-5711. PMID: 34754216 -
Metabolites
2026 Jan 8;16(1):53. PMID: 41590661 -
Brain Res Bull
Pharmacological inhibition of Kv1.3 channel reduces sevoflurane-induced cognitive impairment through NLRP3-dependent microglial modulation. [Abstract]2025 Jun 1:225:111351. PMID: 40252702 -
iScience
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats. [Abstract]2023 Jun 7;26(7):107022. PMID: 37360683 -
Poultry Sci
Hydroxytyrosol mitigates Mycoplasma gallisepticum-induced pulmonary injury through downregulation of the NF-κB/NLRP3/IL-1β signaling pathway in chicken. [Abstract]2023 May;102(5):102582. PMID: 36940652 -
Neurochem Res
2022 Jul;47(7):1904-1916. PMID: 35352213 -
Acta Biochim Biophys Sin (Shanghai)
NLRP3 inflammasome signal pathway involves in Vibrio harveyi-induced inflammatory response in murine peritoneal macrophages in vitro. [Abstract]2021 Dec 8;53(12):1590-1601. PMID: 34569606 -
FASEB J
The Mechanism of Action of NMN in Inhibiting NLRP3 Acetylation-Mediated Granulosa Cell Pyroptosis to Improve Ovarian Reserve Function in Ionizing Radiation-Exposed Mice. [Abstract]2025 Dec 31;39(24):e71335. PMID: 41395774 -
FASEB J
TREM-1 Promotes Microglial Pyroptosis and Mitochondrial Fission in Intracerebral Hemorrhage via the PI3K/AKT Pathway. [Abstract]2025 Oct 15;39(19):e71115. PMID: 41065767 -
Biology (Basel)
7-Methoxyflavanone Alleviates LPS-Induced Acute Lung Injury by Suppressing TLR4/NF-κB p65 and ROS/Txnip/NLRP3 Signaling. [Abstract]2025 Sep 2;14(9):1170. PMID: 41007315 -
FASEB J
2025 Apr 15;39(7):e70530. PMID: 40193045 -
Biochim Biophys Acta Mol Cell Res
FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3. [Abstract]2024 Apr;1871(4):119689. PMID: 38367916 -
Biochim Biophys Acta Mol Cell Res
Modified 5-aminolevulinic acid photodynamic therapy induces cutaneous squamous cell carcinoma cell pyroptosis via the JNK signaling pathway. [Abstract]2024 Jan;1871(1):119603. PMID: 37805058 -
Drug Dev Res
Secoisolariciresinol Diglucoside Alleviates LPS-Induced Acute Lung Injury by Inhibiting the NF-κB/NLRP3 Signaling Pathway. [Abstract]2026 May;87(3):e70285. PMID: 42041133 -
Microbiol Spectr
Inhibiting NLRP3 enhances cellular autophagy induced by outer membrane vesicles from Pseudomonas aeruginosa. [Abstract]2025 Mar 4;13(3):e0181924. PMID: 39873509 -
Immunotargets Ther
NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment. [Abstract]2024 Dec 14:13:775-788. PMID: 39703562 -
Cell Stress Chaperones
Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis. [Abstract]2024 Jun;29(3):440-455. PMID: 38653383 -
Clin Immunol
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis. [Abstract]2023 May:250:109300. PMID: 36963448 -
Microbiol Spectr
Senecavirus a 3D Interacts with NLRP3 to Induce IL-1β Production by Activating NF-κB and Ion Channel Signals. [Abstract]2022 Apr 27;10(2):e0209721. PMID: 35254168 -
Ther Adv Med Oncol
Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine. [Abstract]2021 Jan 21:13:1758835920987056. PMID: 33613696 -
Naunyn Schmiedebergs Arch Pharmacol
Integration of network pharmacology and transcriptomics to reveal the ROS/NLRP3/Caspase-1/GSDMD-mediated mechanism of baicalin in alleviating contrast-induced acute kidney injury. [Abstract]2025 Dec 12. PMID: 41384955 -
Toxins
2023 May 29;15(6):366. PMID: 37368667 -
Naunyn Schmiedebergs Arch Pharmacol
RETRACTED ARTICLE: Physcion 8-O-β-glucopyranoside mediates the NLRP3-associated pyroptosis and cell metastasis in the human osteosarcoma cells via ER stress activation. [Abstract]2021 Mar;394(3):555. PMID: 32072190 -
Microb Pathog
Autophagy induced by Trichinella spiralis infection alleviate TNBS-induced colitis in mice through inhibiting the NLRP3 inflammasome. [Abstract]2026 Jul:216:108526. PMID: 42069093 -
Microb Pathog
Mechanism of tea saponin in alleviating intestinal damage induced by E. coli infection via the NF-κB/NLRP3 pathway. [Abstract]2026 Apr:213:108326. PMID: 41605328 -
Microb Pathog
C. albicans airway colonization amplifies inflammation in emphysema through the ROS/NLRP3 pathway of macrophages. [Abstract]2025 Oct:207:107853. PMID: 40588176 -
Reprod Biomed Online
Blockage of the NLRP3 inflammasome by MCC950 inhibits migration and invasion in adenomyosis. [Abstract]2024 Oct;49(4):104319. PMID: 39121559 -
Clin Exp Immunol
Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome. [Abstract]2024 Jun 20;217(1):89-98. PMID: 38517050 -
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J Tradit Complement Med
Xin-Li formula attenuates heart failure induced by a combination of hyperlipidemia and myocardial infarction in rats via Treg immunomodulation and NLRP3 inflammasome inhibition. [Abstract]2023 Mar 29;13(5):441-453. PMID: 37693100
MCC950 sodium purchased from MedChemExpress. Usage Cited in: J Tradit Complement Med. 2023 Mar 29;13(5):441-453. [Abstract]
MCC950 (10 μM; 1 h) inhibits the expression of NLRP3 in THP-1 cells.
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Cell Cycle
Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling. [Abstract]2021 Oct;20(20):2160-2173. PMID: 34494933 -
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Clin Exp Immunol
2018 Nov;194(2):231-243. PMID: 30277570
MCC950 sodium purchased from MedChemExpress. Usage Cited in: Clin Exp Immunol. 2018 Nov;194(2):231-243. [Abstract]
MCC950 treatment inhibits Nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome pathway activation.
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Viruses
H6N6 Avian Influenza Virus Infection Induced Pyroptosis of M1 Macrophages by Activating Caspase-1. [Abstract]2025 Nov 12;17(11):1492. PMID: 41305513 -
Vet Res
2025 Oct 16;56(1):199. PMID: 41102826 -
Biochim Biophys Acta Mol Cell Biol Lipids
Palmitic acid activates NLRP3 inflammasome through NF-κB and AMPK-mitophagy-ROS pathways to induce IL-1β production in large yellow croaker (Larimichthys crocea). [Abstract]2024 Mar;1869(2):159428. PMID: 38029958 -
Exp Biol Med
TXNIP activates NLRP3/IL-1β and participate in inflammatory response and oxidative stress to promote deep venous thrombosis. [Abstract]2023 Sep;248(18):1588-1597. PMID: 37749991 -
J Microbiol
NF-κB/ROS and ERK pathways regulate NLRP3 inflammasome activation in Listeria monocytogenes infected BV2 microglia cells. [Abstract]2021 Aug;59(8):771-781. PMID: 34061343 -
Front Psychiatry
Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation. [Abstract]2019 Jan 7:9:734. PMID: 30666218 -
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Mol Immunol
Curcumin mitigates testicular ischemia-reperfusion injury by suppressing NLRP3-mediated pyroptosis. [Abstract]2025 Sep:185:71-80. PMID: 40706257 -
Parasit Vectors
A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4-ROS-NLRP3 pathway. [Abstract]2022 Sep 23;15(1):334. PMID: 36151570 -
Int J Med Sci
Ginsenoside Rg1 alleviates acute liver injury through the induction of autophagy and suppressing NF-κB/NLRP3 inflammasome signaling pathway. [Abstract]2021 Jan 23;18(6):1382-1389. PMID: 33628094 -
Mol Immunol
Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity. [Abstract]2020 Jul:123:74-87. PMID: 32438202 -
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Exp Cell Res
ALPK1 promotes cardiomyocyte hypertrophy by activating NF-κB/NLRP3 inflammasome-mediated pyroptosis. [Abstract]2026 Jul 1;460(1):115048. PMID: 42061549 -
Npj Viruses
The soluble G protein of respiratory syncytial virus promotes viral dissemination via TLR2-mediated NLRP3 priming and pyroptosis. [Abstract]2026 Jan 27;4(1):6. PMID: 41593203 -
Exp Cell Res
HMGB1 contributes to pancreatic fibrosis by regulating TLR4-mediated autophagy and the NLRP3 inflammasome pathway in chronic pancreatitis. [Abstract]2025 Sep 1;452(1):114745. PMID: 40915340 -
J Diabetes Res
2024 Nov 23:2024:9378405. PMID: 39619569 -
Exp Cell Res
Exosomes derived from diabetic microenvironment-preconditioned mesenchymal stem cells ameliorate nonalcoholic fatty liver disease and inhibit pyroptosis of hepatocytes. [Abstract]2024 Nov 7;443(2):114325. PMID: 39521106 -
Exp Cell Res
Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia. [Abstract]2024 Apr 30;438(2):114061. PMID: 38692345 -
Arch Biochem Biophys
Increased mitochondrial fission induces NLRP3/cGAS-STING mediated pro-inflammatory pathways and apoptosis in UVB-irradiated immortalized human keratinocyte HaCaT cells. [Abstract]2023 Apr:738:109558. PMID: 36878340 -
Exp Cell Res
2022 Sep 1;418(1):113264. PMID: 35714941 -
Exp Cell Res
Role of NLR family pyrin domain-containing 3 inflammasome in the activation of pancreatic stellate cells. [Abstract]2021 Jul 15;404(2):112634. PMID: 34004193 -
Exp Cell Res
NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation. [Abstract]2019 Oct 1;383(1):111488. PMID: 31276670 -
Endocrinol Diabetes Metab
Targeting the NEK7/NLRP3 Inflammasome Axis: Synergistic Protection of Intravitreal MCC950 and Systemic Metformin Against Diabetic Retinopathy in Rats. [Abstract]2026 Jan;9(1):e70151. PMID: 41588940 -
Mol Cell Endocrinol
NLRP3 blockade by MCC950 suppressed osteoclastogenesis via NF-κB/c-Fos/NFATc1 signal pathway and alleviated bone loss in diabetes mellitus. [Abstract]2024 Dec 1:594:112382. PMID: 39349237 -
Int Immunol
IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjögren's syndrome. [Abstract]2023 Nov 7;35(11):531-542. PMID: 37756640 -
Front Oncol
Antidiabetic DPP-4 Inhibitors Reprogram Tumor Microenvironment That Facilitates Murine Breast Cancer Metastasis Through Interaction With Cancer Cells via a ROS-NF-кB-NLRP3 Axis. [Abstract]2021 Sep 24:11:728047. PMID: 34631556 -
Neural Plast
Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice. [Abstract]2018 Apr 24:2018:9163521. PMID: 29853850 -
BMC Neurosci
Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats. [Abstract]2023 Jan 28;24(1):9. PMID: 36709248 -
Int J Cardiol
H2S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome. [Abstract]2021 Sep 1:338:215-225. PMID: 34157359 -
PPAR Res
Rosiglitazone Alleviates Mechanical Allodynia of Rats with Bone Cancer Pain through the Activation of PPAR- γ to Inhibit the NF- κ B/NLRP3 Inflammatory Axis in Spinal Cord Neurons. [Abstract]2021 Aug 25:2021:6086265. PMID: 34484316 -
Food Chem Toxicol
Targeting the MLKL-F-actin-NLRP3 axis attenuates arsenic-induced myocardial necroinflammation. [Abstract]2025 Nov 21:208:115861. PMID: 41275903 -
Mol Biol Rep
Microglial NLRP3 inflammasome activation leads to perineuronal net loss in cocultured neurons. [Abstract]2025 Oct 13;52(1):1023. PMID: 41082132 -
Pflugers Arch
Targeting NLRP3 inflammasome attenuates cardiac pyroptosis and fibrosis in estrogen-deficient diabetic rats. [Abstract]2025 Jul;477(7):935-952. PMID: 40383837 -
Int J Med Microbiol
E. coli Nissle 1917 improves gut microbiota composition and serum metabolites to counteract atherosclerosis via the homocitrulline/Caspase 1/NLRP3/GSDMD axis. [Abstract]2025 Mar:318:151642. PMID: 39742694 -
Food Chem Toxicol
2023 Nov:181:114060. PMID: 37748573 -
Food Chem Toxicol
L-theanine attenuates porcine intestinal tight junction damage induced by LPS via p38 MAPK/NLRP3 signaling in IPEC-J2 cells. [Abstract]2023 Aug:178:113870. PMID: 37271275 -
Brain Res
Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS/autophagy/NLRP3 signal axis in fibrillar Aβ-activated microglia. [Abstract]2023 Feb 15:1801:148206. PMID: 36539049 -
Food Chem Toxicol
2021 Jan:147:111867. PMID: 33217525 -
Pflugers Arch
2020 Nov;472(11):1577-1586. PMID: 32915316 -
Food Chem Toxicol
Inorganic arsenic induces pyroptosis and pancreatic β cells dysfunction through stimulating the IRE1α/TNF-α pathway and protective effect of taurine. [Abstract]2019 Mar:125:392-402. PMID: 30660605 -
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Exp Eye Res
A novel optic nerve demyelination mouse model: Insights into secondary impairment of the visual cortical circuit. [Abstract]2026 Jun:267:110999. PMID: 41932640 -
Tissue Cell
ROS-TXNIP-NLRP3 inflammasome axis-driven macrophage activation contributes to endothelial dysfunction in Kawasaki disease. [Abstract]2026 May 25. PMID: 42263501 -
BMC Cardiovasc Disord
AdipoRon ameliorates vascular endothelial injury in type 2 diabetes mellitus and is associated with suppression of the NLRP3-Caspase-1-GSDMD pyroptosis axis. [Abstract]2026 May 21. PMID: 42168864 -
Tissue Cell
Melatonin attenuates chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis in alveolar macrophages. [Abstract]2026 Apr:99:103305. PMID: 41500094 -
3 Biotech
Mitochondria-mediated pyroptosis: anti-glioblastoma mechanism of the frankincense-derived compound β-boswellic acid. [Abstract]2026 Feb;16(2):73. PMID: 41550484 -
3 Biotech
Aloe-emodin attenuates Aβ25-35-induced HT22 cell pyroptosis via inhibiting NLRP3 inflammasome pathway. [Abstract]2026 Feb;16(2):71. PMID: 41550486 -
Exp Eye Res
2026 Apr:265:110867. PMID: 41548834 -
3 Biotech
Tao Hong Si Wu decoction attenuates myocardial injury in diabetic mice by regulating the cGAS/STING/NLRP3 axis. [Abstract]2025 Dec;15(12):413. PMID: 41250668 -
Tissue Cell
Ling-Gui-Zhu-Gan decoction inhibits cardiomyocyte pyroptosis via the NLRP3/Caspase-1 signaling pathway. [Abstract]2024 Dec:91:102588. PMID: 39442311 -
BMC Cardiovasc Disord
Effect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury. [Abstract]2024 Jul 10;24(1):351. PMID: 38987672 -
BMC Cardiovasc Disord
Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway. [Abstract]2024 Jul 12;24(1):354. PMID: 38992615 -
Immunobiology
The involvement of oxidative stress and the TLR4/NF-κB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia. [Abstract]2024 May 17;229(3):152809. PMID: 38788361 -
Platelets
Platelet-derived microparticles stimulated by anti-β2GPI/β2GPI complexes induce pyroptosis of endothelial cells in antiphospholipid syndrome. [Abstract]2023 Dec;34(1):2156492. PMID: 36550078 -
BMC Cardiovasc Disord
Sodium tanshinone IIA sulfonate ameliorates neointima by protecting endothelial progenitor cells in diabetic mice. [Abstract]2023 Sep 11;23(1):446. PMID: 37697234 -
Kaohsiung J Med Sci
Total saponins of Aralia elata (Miq.) Seem. alleviate myocardial ischemia-reperfusion injury by promoting NLRP3-inflammasome inactivation via PI3K/Akt signaling. [Abstract]2023 Mar;39(3):290-301. PMID: 36408810 -
Exp Eye Res
Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation. [Abstract]2021 Aug:209:108668. PMID: 34144035 -
J Neuroimmunol
A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease. [Abstract]2021 May 15:354:577543. PMID: 33714750 -
Am J Physiol Gastrointest Liver Physiol
Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease. [Abstract]2021 Jun 1;320(6):G1034-G1044. PMID: 33728991 -
J Cell Biochem
Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis. [Abstract]2019 Apr;120(4):5160-5168. PMID: 30320900 -
Fitoterapia
The processed Euphorbia lathyris L. alleviates the inflammatory injury via regulating LXRα/ABCA1 expression and TLR4 positioning to lipid rafts. [Abstract]2024 Sep:177:106111. PMID: 38971330 -
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PLoS One
Impact of blast exposure on visual pathway: Mechanism exploration and novel diagnostic perspectives. [Abstract]2026 Mar 25;21(3):e0344993. PMID: 41880282 -
PLoS One
Inhibition of TREM1 attenuates myocardial ischemia-reperfusion injury-induced cardiomyocyte pyroptosis by suppressing the activation of the NF-κB signaling pathway. [Abstract]2026 Jan 9;21(1):e0340382. PMID: 41511954 -
Vet Microbiol
The critical role of NLRP3 inflammasome activation in Streptococcus suis-induced blood-brain barrier disruption. [Abstract]2024 Aug:295:110161. PMID: 38945021 -
Vet Microbiol
ATP-dependent activation of NLRP3 inflammasome in primary murine macrophages infected by pseudorabies virus. [Abstract]2021 Aug:259:109130. PMID: 34052623 -
PLoS One
Estrogen protects against liver damage in sepsis through inhibiting oxidative stress mediated activation of pyroptosis signaling pathway. [Abstract]2020 Oct 1;15(10):e0239659. PMID: 33002070 -
Dig Dis Sci
Propofol Does Not Reduce Pyroptosis of Enterocytes and Intestinal Epithelial Injury After Lipopolysaccharide Challenge. [Abstract]2018 Jan;63(1):81-91. PMID: 29063417
MCC950 sodium purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Jan;63(1):81-91. [Abstract]
The expression of various molecules in pyroptotic and apoptotic pathways is detected by western blot. Representative bands from densitometric analysis in experimental groups are presented. M, MCC950 group (an inhibitor of NLRP3).
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Vet Sci
Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion. [Abstract]2024 Dec 12;11(12):643. PMID: 39728983 -
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Burns
Nucleotide-binding domain-like receptor protein 3 inflammasome contributes to vascular endothelial barrier dysfunction and shock after burn injury. [Abstract]2025 Jun 27;51(7):107589. PMID: 40651119 -
Anat Rec
Resibufogenin suppresses growth and metastasis through inducing caspase-1-dependent pyroptosis via ROS-mediated NF-κB suppression in non-small cell lung cancer. [Abstract]2021 Feb;304(2):302-312. PMID: 32396707 -
Biochem Biophys Res Commun
2025 Aug 15:775:152110. PMID: 40450990 -
Biochem Biophys Res Commun
2019 Jun 30;514(3):998-1003. PMID: 31092335 -
Immunol Invest
Astragalus Polysaccharide Promotes NLRP3+ Macrophages Polarization via Suppression of OGT in Hepatocellular Carcinoma. [Abstract]2026 May;55(4):750-773. PMID: 41877503 -
Arch Oral Biol
Ginsenoside Rg1 alleviates lipopolysaccharide-induced pyroptosis in human periodontal ligament cells via inhibiting Drp1-mediated mitochondrial fission. [Abstract]2023 Mar:147:105632. PMID: 36736069 -
Arch Oral Biol
Targeting the Nod-like receptor protein 3 Inflammasome with inhibitor MCC950 rescues lipopolysaccharide-induced inhibition of osteogenesis in Human periodontal ligament cells. [Abstract]2021 Nov:131:105269. PMID: 34601319 -
Cytotechnology
Panax notoginseng-Bletilla striata ameliorates reflux esophagitis by modulating NLRP3 inflammasomes and p38 MAPK pathway. [Abstract]2026 Feb;78(1):3. PMID: 41280658 -
Exp Ther Med
A20 affects macrophage polarization through the NLRP3 inflammasome signaling pathway and promotes breast cancer progression. [Abstract]2023 Feb 15;25(4):147. PMID: 36911385 -
Exp Ther Med
Dexmedetomidine alleviates inflammation in neuropathic pain by suppressing NLRP3 via Nrf2 activation. [Abstract]2021 Oct;22(4):1046. PMID: 34434260 -
Oncol Lett
2020 Nov;20(5):170. PMID: 32934737 -
Microbiol Immunol
Human Cytomegalovirus infection activates NLRP3 inflammasome by releasing mtDNA into cytosol in human THP-1 cells. [Abstract]2023 Jun;67(6):303-313. PMID: 36932814 -
Biosci Biotechnol Biochem
Mito-tempo alleviates ox-LDL-provoked foam cell formation by regulating Nrf2/NLRP3 signaling. [Abstract]2024 Jun 21;88(7):759-767. PMID: 38719485 -
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bioRxiv
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3. [Abstract]2025 Oct 30:2025.10.29.685328. PMID: 41279623 -
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Heliyon
NLRP3 inhibitor combined with Yimusake improves erectile dysfunction in rats with diabetes mellitus through the attenuation of pyroptosis. [Abstract]2024 Sep 27;10(19):e38626. PMID: 39391494 -
Biomed Pharmacother
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. [Abstract]2024 Aug:177:117006. PMID: 38908197 -
Heliyon
New compatible pair of TCM: Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation. [Abstract]2024 Jul 14;10(14):e34591. PMID: 39130485 -
Sci Total Environ
NLRP3 inflammasome activation triggers severe inflammatory liver injury in N, N-dimethylformamide-exposed mice. [Abstract]2024 Jun 15:929:172653. PMID: 38649053 -
Heliyon
Asprosin promotes vascular inflammation via TLR4-NFκB-mediated NLRP3 inflammasome activation in hypertension. [Abstract]2024 May 23;10(11):e31659. PMID: 38841464 -
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Heliyon
Shengmai injection inhibits palmitic acid-induced myocardial cell inflammatory death via regulating NLRP3 inflammasome activation. [Abstract]2023 Nov 2;9(11):e21522. PMID: 38027923 -
Environ Sci Pollut Res Int
Filamin A facilitates NLRP3 inflammasome activation during arsenic-induced nonalcoholic steatohepatitis. [Abstract]2023 Oct;30(49):107703-107715. PMID: 37740811 -
Sci Total Environ
Activation of NLRP3 signaling contributes to cadmium-induced bone defects, associated with autophagic flux obstruction. [Abstract]2023 Oct 1:893:164787. PMID: 37321488 -
Biomed Pharmacother
Daphnetin ameliorates PM2.5-induced airway inflammation by inhibiting NLRP3 inflammasome-mediated pyroptosis in CS-exposed mice. [Abstract]2023 Sep:165:115047. PMID: 37390709 -
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Sci Total Environ
Combined exposure to benzo(a)pyrene and dibutyl phthalate aggravates pro-inflammatory macrophage polarization in spleen via pyroptosis involving cathepsin B. [Abstract]2023 Jul 10:881:163460. PMID: 37061049 -
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Biomed Pharmacother
Mechanical stress protects against chondrocyte pyroptosis through TGF-β1-mediated activation of Smad2/3 and inhibition of the NF-κB signaling pathway in an osteoarthritis model. [Abstract]2023 Mar:159:114216. PMID: 36634591 -
Oxid Med Cell Longev
Curcumin Ameliorates Age-Induced Tight Junction Impaired in Porcine Sertoli Cells by Inactivating the NLRP3 Inflammasome through the AMPK/SIRT3/SOD2/mtROS Signaling Pathway. [Abstract]2023 Feb 17:2023:1708251. PMID: 36846717 -
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Biomed Pharmacother
Inhibition of the NLRP3/caspase-1 signaling cascades ameliorates ketamine-induced renal injury and pyroptosis in neonatal rats. [Abstract]2022 Aug:152:113229. PMID: 35679721 -
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Oxid Med Cell Longev
Inhibiting Microglia-Derived NLRP3 Alleviates Subependymal Edema and Cognitive Dysfunction in Posthemorrhagic Hydrocephalus after Intracerebral Hemorrhage via AMPK/Beclin-1 Pathway. [Abstract]2022 May 17;2022:4177317. PMID: 35620574 -
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Bioengineered
Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model. [Abstract]2022 Mar;13(3):4810-4820. PMID: 35188436 -
Oxid Med Cell Longev
HBO Alleviates Neural Stem Cell Pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 Axis and Improves Neurogenesis after Oxygen Glucose Deprivation. [Abstract]2022 Feb 7;2022:9030771. PMID: 35178162 -
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Aging (Albany NY)
2021 Aug 25;13(16):20534-20551. PMID: 34432650 -
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Oxid Med Cell Longev
Resveratrol Confers Vascular Protection by Suppressing TLR4/Syk/NLRP3 Signaling in Oxidized Low-Density Lipoprotein-Activated Platelets. [Abstract]2021 Feb 25:2021:8819231. PMID: 33728029 -
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Chemosphere
Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis. [Abstract]2020 Mar:242:124959. PMID: 31669990 -
Evid Based Complement Alternat Med
Bushen-Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson's Disease. [Abstract]2018 Aug 26:2018:3571604. PMID: 30224927
용액&용해도
In Vitro:
DMSO : 100 mg/mL (234.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 30 mg/mL (70.35 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 5% DMSO 95% PBS
Solubility: ≥ 5 mg/mL (11.72 mM); Clear solution
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 2% DMSO 98% PBS
Solubility: ≥ 2 mg/mL (4.69 mM); Clear solution
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 6.25 mg/mL (14.66 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55. [Content Brief]
[2]. Zhai Y, et al. Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. Molecules. 2018 Feb 27;23(3). pii: E522. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.3449 mL | 11.7244 mL | 23.4489 mL | 58.6221 mL |
| 5 mM | 0.4690 mL | 2.3449 mL | 4.6898 mL | 11.7244 mL | |
| 10 mM | 0.2345 mL | 1.1724 mL | 2.3449 mL | 5.8622 mL | |
| 15 mM | 0.1563 mL | 0.7816 mL | 1.5633 mL | 3.9081 mL | |
| 20 mM | 0.1172 mL | 0.5862 mL | 1.1724 mL | 2.9311 mL | |
| 25 mM | 0.0938 mL | 0.4690 mL | 0.9380 mL | 2.3449 mL | |
| 30 mM | 0.0782 mL | 0.3908 mL | 0.7816 mL | 1.9541 mL | |
| 40 mM | 0.0586 mL | 0.2931 mL | 0.5862 mL | 1.4656 mL | |
| 50 mM | 0.0469 mL | 0.2345 mL | 0.4690 mL | 1.1724 mL | |
| 60 mM | 0.0391 mL | 0.1954 mL | 0.3908 mL | 0.9770 mL | |
| DMSO | 80 mM | 0.0293 mL | 0.1466 mL | 0.2931 mL | 0.7328 mL |
| 100 mM | 0.0234 mL | 0.1172 mL | 0.2345 mL | 0.5862 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MCC950 sodium Related Classifications
HY-12815A Related Classifications
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