MCC950 sodium

MCC950 sodium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2018 Mar 24;15(1):95. [Abstract]

Chronic PVN infusion of MCC950 significantly decreases apoptosis-associated speck-like protein (ASC), pro-caspase-1, and IL-1β expression in high-salt diet rats.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Sep 20;9(10):946.  [Abstract]

The efficiency of MCC950, and its effect on caspase-1 activation and IL-1β production in As2O3-treated HepG2 cells.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: EMBO J. 2022 Oct 17;e111173. [Abstract]

BMDMs isolated from Phb1F/F mice and Phb1MyeKO mice are incubated with MCC950 (50 nM) for 30 min and are subsequently stimulated by LPS (200 ng/ml) for 6 h and ATP (4 mM) for 45 min. Protein levels in whole cell lysates and culture medium are detected by WB assay.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2023 May 10;71(18):7032-7045. [Abstract]

MCC950 (10 μM; 2 h) markedly inhibits the expressionof NLRP3, Cleaved Caspase-1, and Cleaved IL-1β in HUVECs.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: Neurobiol Dis. 2018 Sep:117:15-27. [Abstract]

Effect of MCC950 on the expression of NLRP3 inflammasome components and substrates after traumatic brain injury (TBI).

MCC950 sodium purchased from MedChemExpress. Usage Cited in: J Am Heart Assoc. 2017 Sep 4;6(9). pii: e006347. [Abstract]

Cells are pretreated with YVAD(10 μM) or MCC950 (10 μM) for 2 hours, and then exposed to TMAO (600 μM) for a further 24 hours. Expression of IL-1β, ICAM-1, MMP-9, and caspase-1 p20 is detected via Western blot.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: Biofactors. 2018 Mar;44(2):123-136. [Abstract]

NLRP3, Casp1 p20, IL-1b, and ICAM-1 protein levels are assessed in the cell lysates by Western blotting.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Mar 27;24(7):6309. [Abstract]

MCC950 (5 μM; every other day for four weeks) significantly decreases CD68⁺ and GSDMD⁺ cells in rats.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: Molecules. 2018 Feb 27;23(3). pii: E522. [Abstract]

Effects of MCC950 on hippocampal NLRP3 inflammasome activation in db/db mice. Western blot analysis of NLRP3 inflammasome-associated NLRP3, ASC, IL-1β, and β-actin are performed in the hippocampus of each group.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: Clin Exp Immunol. 2018 Nov;194(2):231-243. [Abstract]

MCC950 treatment inhibits Nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome pathway activation.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta. 2017 Oct 3;1864(1):1-10. [Abstract]

MCC950 or vehicle control (PBS) is administered at 1, 4 and 6 day after Ang II infusion in the absence or presence of EMD638683. Representative images and quantification of picrosirius red-stained collagen in the heart at 7 days after Ang II infusion.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: J Tradit Complement Med. 2023 Mar 29;13(5):441-453. [Abstract]

MCC950 (10 μM; 1 h) inhibits the expression of NLRP3 in THP-1 cells.

MCC950 sodium purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Jan;63(1):81-91. [Abstract]

The expression of various molecules in pyroptotic and apoptotic pathways is detected by western blot. Representative bands from densitometric analysis in experimental groups are presented. M, MCC950 group (an inhibitor of NLRP3).