STAT5-IN-2
Based on 2 publication(s) in Google Scholar
STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.
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- Purity: 98.90%
- CAS No.: 2111834-61-6
- 화학식: C26H27N3O
- 분자량:397.51
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Apoptosis Compound Library
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Publications Citing Use of MedChemExpress (MCE) STAT5-IN-2
More
Biological Activity
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STAT5 9 μM (EC50, in K562 cells) |
STAT5 5 μM (EC50, in KU812 cells ) |
STAT5-IN-2 has EC50 values of 9 μM and 5 μM in K562 and KU812 cells, respectively[1].
STAT5-IN-2 (100 nM-50 μM; 48 hours) has EC50 values of 2.6 μM and 3.5 μM in KG1a and MV-4-11 cells, respectively[1].
STAT5-IN-2 (10 μM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells)[1].
STAT5-IN-2 (10 μM; 24 hours) blocks phosphorylation of STAT5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:KG1a and MV-4-11 cell lines
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Concentration:100 nM, 10 µM, 20 µM, 30 µM, 40 µM, 50 µM
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Incubation Time:48 hours
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Result:Inhibited cell growth in KG1a and MV-4-11 cell lines
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Cell Line:K562, KU812, KG1a and MV-4-11 cells
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Concentration:10 µM
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Incubation Time:48 hours
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Result:Significantly increased the number of apoptotic cells.
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Cell Line:KG1a, MV-4-11 and KU812 cells
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Concentration:10 µM
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Incubation Time:24 hours
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Result:Inhibited phosphorylation of STAT5 compared to no influence on phosphorylation level of STAT3, Akt and Erk1/2.
Chemical Information
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CAS No. 2111834-61-6
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Appearance Solid
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분자량 397.51
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화학식 C26H27N3O
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Color Off-white to light yellow
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SMILES
CC(CCN1CCOC2=CC(C=CN3)=C3C=C2)(C)C4=C1C=CC(C5=CC=CN=C5)=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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J Exp Med
Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity. [Abstract]2021 Sep 6;218(9):e20210009. PMID: 34279541 -
J Immunol
Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells. [Abstract]2022 Oct 1;209(7):1401-1413. PMID: 36038289
용액&용해도
DMSO : 100 mg/mL (251.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (275 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5157 mL | 12.5783 mL | 25.1566 mL | 62.8915 mL |
| 5 mM | 0.5031 mL | 2.5157 mL | 5.0313 mL | 12.5783 mL | |
| 10 mM | 0.2516 mL | 1.2578 mL | 2.5157 mL | 6.2891 mL | |
| 15 mM | 0.1677 mL | 0.8386 mL | 1.6771 mL | 4.1928 mL | |
| 20 mM | 0.1258 mL | 0.6289 mL | 1.2578 mL | 3.1446 mL | |
| 25 mM | 0.1006 mL | 0.5031 mL | 1.0063 mL | 2.5157 mL | |
| 30 mM | 0.0839 mL | 0.4193 mL | 0.8386 mL | 2.0964 mL | |
| 40 mM | 0.0629 mL | 0.3145 mL | 0.6289 mL | 1.5723 mL | |
| 50 mM | 0.0503 mL | 0.2516 mL | 0.5031 mL | 1.2578 mL | |
| 60 mM | 0.0419 mL | 0.2096 mL | 0.4193 mL | 1.0482 mL | |
| 80 mM | 0.0314 mL | 0.1572 mL | 0.3145 mL | 0.7861 mL | |
| 100 mM | 0.0252 mL | 0.1258 mL | 0.2516 mL | 0.6289 mL |
STAT5-IN-2 Related Classifications
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