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TPEN

(Synonyms: TPEDA)
28 Cited Publications
고객리뷰

Based on 28 publication(s) in Google Scholar

TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn2+, but a lower affinity for Mg2+ and Ca2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis.

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  • Purity : 99.91%
  • CAS No.: 16858-02-9
  • 화학식: C26H28N6
  • 분자량:424.55
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • TPEN Chemical Structure
    TPEN Chemical Structure
  • Experimental Validation Results for TPEN
  • Experimental Validation Results for TPEN
  • Experimental Validation Results for TPEN
  • Experimental Validation Results for TPEN
  • Experimental Validation Results for TPEN
  • Experimental Validation Results for TPEN
CAS No.: 16858-02-9
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Publications Citing Use of MedChemExpress (MCE) TPEN

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Flow CytometryCell Imaging/StainingCell Migration/Invasion AssayWBIHC
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  • Flow Cytometry
  • Cell Imaging/Staining
  • Cell Migration/Invasion Assay
  • WB
  • IHC

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  • TPEN Chemical Structure
    TPEN Chemical Structure
    1/16
  • 1/16

    TPEN purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep;12(33):e08280. [Abstract]

    Customer Validation
     HCT116 cells were treated with TPEN (0, 2.5, 5, and 10 μM) for 1 h, starved in PBS for 1 h, and then supplemented with ZnSO4 for the indicated time. The levels of pS473-AKT, pT308-AKT, p-S6, and the indicated protein were detected by WB.

  • 1/16

    TPEN purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2023 Sep 4;21(1):316. [Abstract]

    Customer Validation
     DPSCs were treated with TPEN (0 and 0.5 µM) combined with ZIF-8 at a concentration gradient (0, 2.5, 5, 10, 20, and 50 µg/ml). After 24 h of treatment, flow cytometry was used to detect FITC and PE.

  • 1/16

    TPEN purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2023 Sep 4;21(1):316. [Abstract]

    Customer Validation
     Fluorescent images of calcein-labeled DPSCs cells treated with TPEN (0, 0.25, 0.5, 1, 1.5, and 2 µM) with ZIF-8 (20 µg/ml) in B27 medium for 6 days.

  • 1/16

    TPEN purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2023 Sep 4;21(1):316. [Abstract]

    Customer Validation
     DPSCs were treated with TPEN (0 and 0.5 µM) combined with ZIF-8 at a concentration gradient (0 and 20 µg/ml), and the medium was co-cultured with HUVECs. Then, cells were stained with crystal violet stain for Transwell experiments. The number of transferred cells was quantified.

  • 1/16

    TPEN purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2020 Oct;26(10):1058-1068. [Abstract]

    Customer Validation
     The Western blot results show that compared to the control group, the expression of cleaved MMP9 is increased by ZnCl2 treatment and decreased by 100 μM TPEN.

  • 1/16

    TPEN purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2020 Oct;26(10):1058-1068. [Abstract]

    Customer Validation
     The immunohistochemistry assay reveales that exposure to 100 μM TPEN significantly decreases the extent of neuronal apoptosis in the GCL of the rat retina.

  • TPEN