AChE-IN-63
AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 876685-78-8
- 화학식: C18H19N5O
- 분자량:321.38
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
hAChE 0.103 μM (IC50) |
hBCHE 10 μM (IC50) |
In Vitro
AChE-IN-63 (5-20 μM; 48 h) inhibits Aβ1-42 aggregation in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
AChE-IN-63 (p.o.; 5-20 mg/kg; single dose) improves learning and memory in cognitive dysfunction mice in the Scopolamine (HY-N0296) Y-Maze Model and demonstrates good antioxidant properties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Scopolamine Y-Maze Model [1]
-
Dosage:5; 10 ;20 mg/kg
-
Administration:p.o.; single dose
-
Result:Showed significant improvement in spontaneous alternation behavior.
Reduced AChE and MDA levels and increased CAT levels.
Chemical Information
-
CAS No. 876685-78-8
-
분자량 321.38
-
화학식 C18H19N5O
-
SMILES
C1(C2=NN=C(O2)CN3CCN(CC3)C4=CC=CC=N4)=CC=CC=C1
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
-
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-63 Related Classifications
HY-158261 Related Classifications
Powered by Bioz