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Cat. No.: HY-147198

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Antimalarial agent 13

Name: Antimalarial agent 13
Brand: MedChemExpress
SKU: HY-147198
Price: 316.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Antimalarial agent 13 (Compound 1) is a potent antimalarial agent. Antimalarial agent 13 shows inhibition with EC₅₀ values of 124 nM and 2.5 μM against P. falciparum parasite and HepG2, respectively.

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CAS No.: 431884-01-4
화학식: C₁₉H₁₅ClN₄O
분자량:350.80

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antimalarial agent 13 Chemical Structure

CAS No.: 431884-01-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
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Biological Activity

제품 설명

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	5 μM Compound: 14	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by Cell Titer-Glo assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by Cell Titer-Glo assay	[PMID: 28080063]

Chemical Information

CAS No. 431884-01-4
분자량 350.80
화학식 C₁₉H₁₅ClN₄O
SMILES

ClC1=CC=CC(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gilson PR, et al. Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity. J Med Chem. 2017 Feb 9;60(3):1171-1188. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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순도&문서
References

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Antimalarial agent 13

All Parasite Isoforms