AO-022
AO-022 is a potent TALDO1 allosteric inhibitor. AO-022 decreases the expression of vimentin and snail. AO-022 shows antiproliferative activity and antitumor activity. AO-022 has the potential for the research of breast cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C21H16ClNO4S
- 분자량:413.87
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
TALDO1[1]
AO-022 (5, 10, 20, 40, 80 µM; 24 h) inhibits cell viability in a dose-dependent manner in MDA-MB-231 cells[1].
AO-022 (0, 2.5,5, 10, 20 µM; 24 h) decreases the protein expression of vimentin and snail in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:0, 2.5,5, 10, 20 µM
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Incubation Time:24 h
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Result:Inhibited the protein expression of vimentin and snail in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old female nude mice (MDA-MB-231 cells)[1]
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Dosage:50 mg/kg
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Administration:I.p.; every other day for fourteen days
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Result:Significantly reduced tumor volume and tumor weight.
Chemical Information
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분자량 413.87
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화학식 C21H16ClNO4S
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SMILES
O=C1N(CC2=CC=CS2)C3=C(C=C(Cl)C=C3)[C@]1(O)CC(C4=CC=CC=C4O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Xu G, Huang R, Wumaier R, Lyu J, Huang M, Zhang Y, Chen Q, Liu W, Tao M, Li J, Tao Z, Yu B, Xu E, Wang L, Yu G, Gires O, Zhou L, Zhu W, Ding C, Wang H. Proteomic Profiling of Serum Extracellular Vesicles Identifies Diagnostic Signatures and Therapeutic Targets in Breast Cancer. Cancer Res. 2024 Jun 20. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AO-022 Related Classifications
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