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Cat. No.: HY-114422

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p38α-IN-13

p38α-IN-13 is p38α MAPK, BChE and AChE inhibitor with IC₅₀ values of 5.79, 16.24, 51.8 µM for p38α MAP, hBChE, hAChE, respectively. p38α-IN-13 has the potential for the research of Alzheimer’s disease.

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CAS No.: 3077831-12-7
화학식: C₂₂H₂₆F₂N₄O₂
분자량:416.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

p38α-IN-13 Chemical Structure

CAS No.: 3077831-12-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^{[1]

p38α MAPK
5.79 μM (IC₅₀)

hBCHE
16.24 μM (IC₅₀)

hAChE
51.8 μM (IC₅₀)

All p38 MAPK Isoforms :

p38 MAPK

p38α

p38β

MAPK13

p38δ

p38γ

All Cholinesterase (ChE) Isoforms :

AChE

BChE}

In Vitro

p38α-IN-13 (5-(2,4-difluorophenoxy)-N-(2-(dimethylamino)ethyl)-2-isobutyl-2H-indazole-6-carboxamide) is a p38α MAPK, BChE and AChE inhibitor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 3077831-12-7
분자량 416.46
화학식 C₂₂H₂₆F₂N₄O₂
SMILES

O=C(C1=CC2=NN(CC(C)C)C=C2C=C1OC3=CC=C(F)C=C3F)NCCN(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Svit Ferjancic BENETIK, et al. 5,6-DISUBSTITUTED ALKYL 1H AND 2H-INDAZOLES AS DUAL BUTYRYLCHOLINESTERASE AND p38α MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE AND INFLAMMATORY DISEASES. WO2025056518A1.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

p38α-IN-13

All p38 MAPK Isoforms

All Cholinesterase (ChE) Isoforms