AS-85
Based on 1 Customer Validation
AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 μM.
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- Purity: 98.05%
- CAS No.: 2323623-80-7
- 화학식: C26H28F3N5O3S2
- 분자량:579.66
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보관:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
More
Biological Activity
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ASH1L/KMT2H |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KOPN-8 | GI50 |
5 μM
Compound: 45; AS-85
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Growth inhibition of human KOPN-8 cells
Growth inhibition of human KOPN-8 cells
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[PMID: 38805937] |
| MOLM-13 | GI50 |
5 μM
Compound: 45; AS-85
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Growth inhibition of human MOLM-13 cells
Growth inhibition of human MOLM-13 cells
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[PMID: 38805937] |
| MV4-11 | GI50 |
5 μM
Compound: 45; AS-85
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Growth inhibition of human MV4-11 cells after 7 days by WST-8 assay
Growth inhibition of human MV4-11 cells after 7 days by WST-8 assay
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[PMID: 38805937] |
AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring different MLL1 translocations, with GI50 values ranging from 5 μM to 25 μM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2323623-80-7
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Appearance Solid
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분자량 579.66
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화학식 C26H28F3N5O3S2
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Color Light yellow to yellow
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SMILES
O=C(C1CNC1)NCC2=CC3=C(C=C2)C(C4=CC=CC(C(N)=S)=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : 100 mg/mL (172.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7251 mL | 8.6257 mL | 17.2515 mL | 43.1287 mL |
| 5 mM | 0.3450 mL | 1.7251 mL | 3.4503 mL | 8.6257 mL | |
| 10 mM | 0.1725 mL | 0.8626 mL | 1.7251 mL | 4.3129 mL | |
| 15 mM | 0.1150 mL | 0.5750 mL | 1.1501 mL | 2.8752 mL | |
| 20 mM | 0.0863 mL | 0.4313 mL | 0.8626 mL | 2.1564 mL | |
| 25 mM | 0.0690 mL | 0.3450 mL | 0.6901 mL | 1.7251 mL | |
| 30 mM | 0.0575 mL | 0.2875 mL | 0.5750 mL | 1.4376 mL | |
| 40 mM | 0.0431 mL | 0.2156 mL | 0.4313 mL | 1.0782 mL | |
| 50 mM | 0.0345 mL | 0.1725 mL | 0.3450 mL | 0.8626 mL | |
| 60 mM | 0.0288 mL | 0.1438 mL | 0.2875 mL | 0.7188 mL | |
| 80 mM | 0.0216 mL | 0.1078 mL | 0.2156 mL | 0.5391 mL | |
| 100 mM | 0.0173 mL | 0.0863 mL | 0.1725 mL | 0.4313 mL |
AS-85 Related Classifications
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