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AZ-TAK1

AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines.

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CAS No.: 1413440-36-4
화학식: C₂₅H₂₈FN₇O₂
분자량:477.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AZ-TAK1 Chemical Structure

CAS No.: 1413440-36-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Bioz

Biological Activity

제품 설명

AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines^[1].

All MAP3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
LoVo	IC₅₀	75 nM Compound: 2	Growth inhibition of human LoVo cells after 96 hrs by SRB assay Growth inhibition of human LoVo cells after 96 hrs by SRB assay	[PMID: 30576901]
SK-CO-1	IC₅₀	61 nM Compound: 2	Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay Growth inhibition of human SKCO1 cells after 96 hrs by SRB assay	[PMID: 30576901]
SW-620	IC₅₀	38 nM Compound: 2	Growth inhibition of human SW620 cells after 96 hrs by SRB assay Growth inhibition of human SW620 cells after 96 hrs by SRB assay	[PMID: 30576901]

In Vitro

AZ-TAK1 (0.1μM) induces apoptosis in 28%, 24%, and 74% of Mino, SP53, and Jeko cells, respectively^[1].
AZ-TAK1 increases mitochondrial depolarization, indicated by a decrease in the red/green fluorescence intensity ratio^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1413440-36-4
분자량 477.53
화학식 C₂₅H₂₈FN₇O₂
SMILES

FC1=C(C2=CN=C3C=CC=NN32)N=C(NC4=CC(OCCN5CCC(CC5)O)=CC(CC)=C4)N=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Daniela Buglio, et al. Essential role of TAK1 in regulating mantle cell lymphoma survival. Blood. 2012 Jul 12;120(2):347-55. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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