BL-1005
BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC50 of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC50 >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection.
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- 화학식: C19H17ClF2N4OS
- 분자량:422.88
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
BL-1005 (0.02-50 μM; 48 h) reduces cell viability in HEK293, HeLa and HepG2 cells with a CC50 of 37.3, 21.3 and 22.5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Note | Cmax | T1/2 |
|---|---|---|---|---|---|
| Mice | 2.5 mg/kg | i.p. | 文献审核 | 247.3 ng/mL | 1.51 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Schistosoma mansoni (adult and juvenile, 28-42-day-old)[1]
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Dosage:0.6 μM, 1.2 μM
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Administration:2 h
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Result:Induced a sustained paralysis in both adult and juvenile S. mansoni, with partial recovery of motility over 9 days.
Chemical Information
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분자량 422.88
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화학식 C19H17ClF2N4OS
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SMILES
FC(C=C(C=C1F)N)=C1C(C(Cl)=NC(C2=CC=CS2)=N3)=C3NCC4(C)COC4
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Synonyms
BS2463
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BL-1005 Related Classifications
HY-179116 Related Classifications
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