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Cat. No.: HY-147039

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BOLD-100 free base

(Synonyms: NKP-1339 free base; IT-139 free base; KP-1339 free base)

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution.

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CAS No.: 783324-98-1
화학식: C₁₄H₁₂Cl₄N₄Ru
분자량:479.15

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

BOLD-100 free base Chemical Structure

CAS No.: 783324-98-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 783324-98-1
분자량 479.15
화학식 C₁₄H₁₂Cl₄N₄Ru
SMILES

[Cl-][Ru+4]([Cl-])([Cl-])([N]1=CC2=CC=CC=C2N1)([N]3=CC4=CC=CC=C4N3)[Cl-]
Synonyms

NKP-1339 free base; IT-139 free base; KP-1339 free base
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Biomater Res

Ultrasound-Targeted Nanobubbles Codelivering NKP-1339 and miR-142-5p for Synergistic Mitochondrial Immunogenic Cell Death and PD-L1 Inhibition in Cancer Therapy. [Abstract]

2025 Aug 8:29:0232. PMID: 40785846

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Baier D, et al. The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation. Pharmaceutics. 2022;14(2):238. Published 2022 Jan 20. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

BOLD-100 free base

1 Cited Publications

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BOLD-100 free base

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BOLD-100 free base

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) BOLD-100 free base

All HSP Isoforms

Biological Activity

Chemical Information

Publications (1)

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BOLD-100 free base Related Classifications

HY-147039 Related Classifications