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Cat. No.: HY-P11646

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Brazzein

Name: Brazzein
Brand: MedChemExpress
SKU: HY-P11646
Availability: PreOrder

Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities.

Brazzein inhibits COX-2 with an IC₅₀ of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC₅₀ = 12.55 μM). Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 178359-31-4
화학식: C₂₇₆H₄₁₀N₇₆O₈₉S₈
분자량:6473.18

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Brazzein Chemical Structure

CAS No.: 178359-31-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities.

IC₅₀ & Target^[1]

COX-2

12.62 μM (IC₅₀)

All COX Isoforms :

In Vitro

Brazzein (15-30 μM) shows strong ABTS radical scavenging activity with an IC₅₀ of 12.55 μM in cell-free conditions^[1].
Brazzein (15-30 μM; 30 min) shows weaker DPPH radical scavenging activity compared to ABTS, with an IC₅₀ > 30 μM in cell-free conditions^[1].
Brazzein (3-25 μM) inhibits human COX-2 activity with an IC₅₀ of 12.62 μM in cell-free conditions^[1].
Brazzein (1–15 μM) shows weak anti-inflammatory activity in RAW 264.7 cells, with an IC₅₀ > 15 μM for NO production inhibition^[1].
Brazzein (1-15 μM) has no cytotoxic effect on RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 178359-31-4
분자량 6473.18
화학식 C₂₇₆H₄₁₀N₇₆O₈₉S₈
Sequence

Glp-Asp-Lys-Cys-Lys-Lys-Val-Tyr-Glu-Asn-Tyr-Pro-Val-Ser-Lys-Cys-Gln-Leu-Ala-Asn-Gln-Cys-Asn-Tyr-Asp-Cys-Lys-Leu-Asp-Lys-His-Ala-Arg-Ser-Gly-Glu-Cys-Phe-Tyr-Asp-Glu-Lys-Arg-Asn-Leu-Gln-Cys-Ile-Cys-Asp-Tyr-Cys-Glu-Tyr (disulfide bridge:Cys4-Cys52,Cys16-Cys37,Cys22-Cys47,Cys26-Cys49)
Sequence Shortening

Glp-DKCKKVYENYPVSKCQLANQCNYDCKLDKHARSGECFYDEKRNLQCICDYCEY (disulfide bridge:Cys4-Cys52,Cys16-Cys37,Cys22-Cys47,Cys26-Cys49)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chung JH, et al. Antioxidant, anti-inflammatory, and anti-allergic activities of the sweet-tasting protein brazzein. Food Chem. 2018;267:163-169. [Content Brief]

[2]. Martinez Raquel, et al. Brazzein as a sustainable alternative to sugar: production, perception, and public health impact. J Appl Biotechnol Bioeng. 2025;12(1):45-48.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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Brazzein

All COX Isoforms