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Cat. No.: HY-137852

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BW284C51

BW284C51 is a highly selective Acetylcholinesterase inhibitor. BW284C51 exerts non-competitive, voltage-dependent blocking effects on the Torpedo nicotinic acetylcholine receptor channel. BW284C51 impairs acetylcholine clearance to increase acetylcholine exposure, and enhances the acetylcholine-mediated expression response of melanogenesis-related genes. BW284C51 can be used in research related to Alzheimer's disease, Parkinson's disease, congenital myasthenia, schizophrenia and familial epilepsy.

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CAS No.: 402-40-4
화학식: C₂₇H₃₈Br₂N₂O
분자량:566.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BW284C51 Chemical Structure

CAS No.: 402-40-4

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

AChE

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

BW284C51 acts as a potent, reversible, voltage-dependent noncompetitive antagonist of Torpedo marmorata nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes, with an IC₅₀ of 0.5 μM for inhibition of 10 μM acetylcholine-elicited currents, and selectively targets nicotinic over muscarinic receptors^[2].
BW284C51 (20 μM) enhances acetylcholine-mediated suppression of melanogenesis, including reduced melanin content, decreased CRE/MITF/TYR promoter activity, and lowered MITF and TYR protein levels, in B16F10 murine melanoma cells^[3].
BW284C51 (20 μM) does not enhance muscarinic acetylcholine receptor agonist-mediated suppression of CRE and MITF promoter activity in B16F10 murine melanoma cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BW284C51 (0.2 mg/kg/day; i.p.; daily; 5 days) increases the proportion of peri-arteriolar and sinusoidal endothelial cells in the marrow of healthy C57BL/6 mice, with endothelial gene expression changes linked to hematopoiesis and immune-related pathways^[1].
BW284C51 (0.2 mg/kg/day; i.p.; daily; 5 days pre-transplant) decreases marrow endothelial cells in syngeneic hematopoietic cell transplant-treated C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6^[1]
Dosage:

0.2 mg/kg/day
Administration:

i.p.; daily; 5 days
Result:

Increased marrow peri-arteriolar endothelial cells to 0.00396 as a proportion of stromal cells, compared to 0.00204 in controls.
Increased sinusoidal endothelial cells to 0.0814 as a proportion of stromal cells, compared to 0.0461 in controls.
Induced differential gene expression in sorted marrow endothelial cells clustered in pathways involving hematopoiesis, leukocyte activation and differentiation, inflammatory responses, and immune regulation.

Animal Model:

C57BL/6^[1]
Dosage:

0.2 mg/kg/day
Administration:

i.p.; daily; 5 days pre-transplant
Result:

Decreased marrow endothelial cells post-hematopoietic cell transplant.

Chemical Information

CAS No. 402-40-4
분자량 566.41
화학식 C₂₇H₃₈Br₂N₂O
SMILES

O=C(CCC1=CC=C([N+](C)(C)CC=C)C=C1)CCC2=CC=C([N+](C)(C)CC=C)C=C2.[Br-].[Br-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Jacobson S, et al. Acetylcholine Affects the Endothelial Marrow Niche: Implications for Engraftment[J]. Transplantation and Cellular Therapy, Official Publication of the American Society for Transplantation and Cellular Therapy, 2026, 32(2): S328.

[2]. Olivera-Bravo S, et al. The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane. British journal of pharmacology. 2005 Jan;144(1):88-97.

[3]. Wu Q, et al. Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. The Journal of biological chemistry. 2018 Sep 14;293(37):14417-14428.

Calculators

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Mass Mass

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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