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Cat. No.: HY-170689

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CG-3-246

CG-3-246 is a dual inhibitor of FLT3/BCL-2, with the K_ds of 63 and 4.25 nM, respectibely. CG-3-246 plays an important role in acute myeloid leukemias research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₆₄H₇₃ClN₁₄O₁₀S
분자량:1265.87

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CG-3-246 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

CG-3-246 is a dual inhibitor of FLT3/BCL-2, with the K_ds of 63 and 4.25 nM, respectibely. CG-3-246 plays an important role in acute myeloid leukemias research^[1].

All Bcl-2 Family Isoforms :

Chemical Information

분자량 1265.87
화학식 C₆₄H₇₃ClN₁₄O₁₀S
SMILES

O=C(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC=C(N4CCN(C(CNC5=CC=C(S(=O)(NC(C6=CC=C(N7CCN(CC8=C(C9=CC=C(Cl)C=C9)CC(C)(C)CC8)CC7)C=C6OC%10=CN=C(NC=C%11)C%11=C%10)=O)=O)C=C5[N+]([O-])=O)=O)CC4)C(OC)=C3)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Christopher C Goodis, et al. The polypharmacy combination of the BCL-2 inhibitor venetoclax (VEN) and the FLT3 inhibitor gilteritinib (GIL) is more active in acute myeloid leukemia cells than novel polypharmacologic BCL-2/FLT3 VEN–GIL hybrid single-molecule inhibitors. Eur J Med Chem. 2024 Dec 22:285:117190. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

CG-3-246

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CG-3-246 Related Classifications

HY-170689 Related Classifications