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Cat. No.: HY-P99845

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Dazodalibep

Name: Dazodalibep
Brand: MedChemExpress
SKU: HY-P99845
Price: 480.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: MEDI-4920; VIB 4920)

고객리뷰

Based on 1 Customer Validation

Dazodalibep (MEDI-4920) is a non-antibody fusion protein that acts as a CD40 ligand (CD40L) antagonist. Dazodalibep is used in the research of rheumatoid arthritis and Sj?gren's syndrome.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 99.0%
CAS No.: 2245953-10-8
분자량:87.82 kDa

보관:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Dazodalibep Chemical Structure

CAS No.: 2245953-10-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Isotype
- Species Reactivity
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Dazodalibep (MEDI-4920) is a non-antibody fusion protein that acts as a CD40 ligand (CD40L) antagonist. Dazodalibep is used in the research of rheumatoid arthritis and Sj?gren's syndrome^[1]^[2]^[3].

Isotype

Fusion - Alternative to antigen receptors (domain scaffold: TNC-F3, tenascin domain F3) 2 TNC-F3 domains

Species Reactivity

Human

All TNF Receptor Isoforms :

In Vitro

Innate ImmunityAdaptive Immunity

Innate Immunity

Adaptive Immunity

Dazodalibep blocks the CD40-CD40L costimulatory interaction between T cells and CD40-expressing B cells and antigen-presenting cells^[2].
Dazodalibep blocks costimulatory signal transduction between T cells, B cells, and antigen-presenting cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Collagen-Induced Arthritis

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

959 [NCBI]

Accession

P29965

Target

TNFSF5/CD40L/CD154

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Alternative to antigen receptors (domain scaffold: TNC-F3, tenascin domain F3)2 TNC-F3 domains

신청

ELISA, FACS, Functional assay

Chemical Information

CAS No. 2245953-10-8
Appearance Liquid
분자량 87.82 kDa
Color Colorless to light yellow
SMILES

[Dazodalibep]
Synonyms

MEDI-4920; VIB 4920
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Bustos AH, et al. Citrullinated peptides as drug candidates for rheumatoid arthritis. Frontiers in immunology. 2025;16:1648913.

[2]. Aung T, et al. Bridging the Gap in Sjögren's Disease: A Comprehensive Review of Unmet Needs, Diagnostic Challenges, and Emerging Therapeutic Strategies. Cureus. 2026 Jul;18(7):e113186.

[3]. Palla P, et al. Infections in Sjögren's disease: a clinical concern or not?. Clinical and experimental rheumatology. 2024 Dec;42(12):2531-2541.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- Isotype
- Species Reactivity
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- 신청
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Dazodalibep

All TNF Receptor Isoforms