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Cat. No.: HY-121398

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Dipivefrin

Dipivefrin is an α/β-adrenoceptor agonist and a prodrug of epinephrine. Dipivefrin regulates intraocular pressure by agonizing α/β-adrenoceptors and modulating the aqueous humor outflow pathway. Dipivefrin acts on neuroblastoma cells and downregulates glutamate-induced intracellular calcium levels. Dipivefrin is used in research related to α/β-adrenoceptor-mediated diseases, such as glaucoma.

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CAS No.: 52365-63-6
화학식: C₁₉H₂₉NO₅
분자량:351.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Dipivefrin Chemical Structure

CAS No.: 52365-63-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

α adrenergic receptor

β adrenergic receptor

All Endogenous Metabolite Isoforms :

All Adrenergic Receptor Isoforms :

In Vitro

Dipivefrin (2.8-280 μM; 100 min) significantly inhibits the proliferation of cultured human corneal stromal cells only at a high concentration of 280 μM^[3].
Dipivefrin (0.28-28 mM; 100 seconds) dose-dependently inhibits glutamate-induced elevation of [Ca²⁺]_i and decreases basal [Ca²⁺]_i in cultured N1E-115 neuroblastoma cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dipivefrin hydrochloride (3 μL of 0.1%; topical ocular; single dose) exhibits a significant intraocular pressure-lowering effect in ddY mice^[1].
Dipivefrin (10 µg/kg; i.p.; before memory retrieval) administered before memory retrieval enhances the ability of alcohol-associated light cues to serve as conditioned reinforcers, indicating bidirectional modulation of alcohol memory reconsolidation through enhanced central adrenergic signaling^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 52365-63-6
분자량 351.44
화학식 C₁₉H₂₉NO₅
SMILES

CC(C)(C(OC1=CC=C(C=C1OC(C(C)(C)C)=O)C(CNC)O)=O)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Endogenous metabolite
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Akaishi T, et al. Ocular hypotensive effects of anti-glaucoma agents in mice. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2009 Oct;25(5):401-8.

[2]. Barak S, et al. Targeting the Reconsolidation of Licit Drug Memories to Prevent Relapse: Focus on Alcohol and Nicotine. International journal of molecular sciences. 2021 Apr 15;22(8):4090.

[3]. Wu KY, et al. Effects of antiglaucoma drugs on cellular proliferation in cultured human corneal keratocytes. The Kaohsiung journal of medical sciences. 2006 Mar;22(3):120-5.

[4]. Hong SJ, et al. Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2003 Jun;19(3):205-15.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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상품명:
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Dipivefrin

All Endogenous Metabolite Isoforms

All Adrenergic Receptor Isoforms