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Cat. No.: HY-183253

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DL149

DL149 is a component of an antibody-drug conjugate (ADC) formed by conjugating the eIF4A inhibitor FD236 (HY-186186) with an ADC linker, and exhibits potential antitumor activity. DL149 can bind to an anti-HER2 antibody to form a complete ADC molecule, which precisely binds to the HER2 receptor on the surface of tumor cells. After internalization into cells, it releases the eIF4A inhibitor payload. DL149 irreversibly blocks the mRNA translation process in tumor cells, thereby inhibiting tumor cell proliferation and inducing their death. DL149 exhibits in vivo antitumor activity in the SK-OV-3 xenograft tumor model, and can be used for the research of HER2-positive solid tumors.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₄₈H₅₉N₅O₁₃
분자량:914.01

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

DL149 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

IC₅₀ & Target

eIF4A

All Drug-Linker Conjugates for ADC Isoforms :

All EGFR Isoforms :

In Vivo

Trastuzumab (HY-P9907)-DL149 ADCs (both DAR4 and DAR8 formats) (5-10 mg/kg) exhibit robust in vivo anti-tumor efficacy in multiple HER2-expressing tumor xenograft models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

분자량 914.01
화학식 C₄₈H₅₉N₅O₁₃
SMILES

O=C(C=C1)N(CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NCOCCNC([C@@H]2[C@@H](C3=CC=CC=C3)[C@@](OC4=C5C(OC)=CC(OC)=C4)(C6=CC=C(OC)C=C6)[C@@]5(O)[C@@H]2O)=O)=O)=O)=O)C1=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Petersen M, et al. Design and evaluation of mRNA translation inhibitors for use as antibody drug conjugate paylo

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

DL149

All Drug-Linker Conjugates for ADC Isoforms

All EGFR Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vivo

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DL149 Related Classifications

HY-183253 Related Classifications

Bioz

Keywords

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