DMeOB
Based on 1 Customer Validation
DMeOB (3,3'-Dimethoxybenzaldazine) is a mGluR5 receptor negative allosteric modulator with an IC50 of 3 μM. DMeOB displays reversible non-competitive inhibition of mGlu5-mediated responses.
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- Purity: 98.55%
- CAS No.: 40252-74-2
- 화학식: C16H16N2O2
- 분자량:268.31
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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mGlu5 3 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
3 μM
Compound: 17
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Negative allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
Negative allosteric modulator activity at human muscarinic acetylcholine receptor M5 expressed in CHO cells by fluorometric imaging plate reader
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[PMID: 25180768] |
Chemical Information
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CAS No. 40252-74-2
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Appearance Solid
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분자량 268.31
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화학식 C16H16N2O2
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Color Light yellow to yellow
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SMILES
COC1=CC(/C=N/N=C/C2=CC=CC(OC)=C2)=CC=C1
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Synonyms
3,3'-Dimethoxybenzaldazine
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (372.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (267 KB)
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SDS (620 KB)
- English - EN (620 KB)
- Français - FR (620 KB)
- Deutsch - DE (620 KB)
- Norwegian - NO (620 KB)
- Español - ES (620 KB)
- Swedish - SV (620 KB)
- Italian - IT (620 KB)
- Korean - KR (620 KB)
- Portuguese - PT (620 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7270 mL | 18.6352 mL | 37.2703 mL | 93.1758 mL |
| 5 mM | 0.7454 mL | 3.7270 mL | 7.4541 mL | 18.6352 mL | |
| 10 mM | 0.3727 mL | 1.8635 mL | 3.7270 mL | 9.3176 mL | |
| 15 mM | 0.2485 mL | 1.2423 mL | 2.4847 mL | 6.2117 mL | |
| 20 mM | 0.1864 mL | 0.9318 mL | 1.8635 mL | 4.6588 mL | |
| 25 mM | 0.1491 mL | 0.7454 mL | 1.4908 mL | 3.7270 mL | |
| 30 mM | 0.1242 mL | 0.6212 mL | 1.2423 mL | 3.1059 mL | |
| 40 mM | 0.0932 mL | 0.4659 mL | 0.9318 mL | 2.3294 mL | |
| 50 mM | 0.0745 mL | 0.3727 mL | 0.7454 mL | 1.8635 mL | |
| 60 mM | 0.0621 mL | 0.3106 mL | 0.6212 mL | 1.5529 mL | |
| 80 mM | 0.0466 mL | 0.2329 mL | 0.4659 mL | 1.1647 mL | |
| 100 mM | 0.0373 mL | 0.1864 mL | 0.3727 mL | 0.9318 mL |
DMeOB Related Classifications
HY-103562 Related Classifications
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