DS17701585
DS17701585 (Compound 11) is a highly selective, orally active EP300 and CBP inhibitor with IC50 values of 0.040, 0.15, 0.45 and 0.70 µM against CBP, EP300, H3K27 and SOX2. DS17701585 can be used for cancer research.
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- CAS No.: 2983027-66-1
- 화학식: C24H26N4O5S
- 분자량:482.55
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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H3K27 0.45 μM (IC50) |
SOX2 0.70 μM (IC50) |
EP300 0.04 μM (IC50) |
CBP 0.15 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LK-2 | IC50 |
0.7 μM
Compound: 11; DS17701585
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Inhibition of SOX2 mRNA expression in human LK2 cells incubated for 6 hrs by RT-qPCR analysis
Inhibition of SOX2 mRNA expression in human LK2 cells incubated for 6 hrs by RT-qPCR analysis
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[PMID: 35413416] |
Chemical Information
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CAS No. 2983027-66-1
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분자량 482.55
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화학식 C24H26N4O5S
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SMILES
O=C([C@@H](C1)N(C(C2(C3=CC=C(OC)C=C3)CCCC2)=O)CS1(=O)=O)NC4=CC=CC5=C4C=NN5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DS17701585 Related Classifications
HY-143443 Related Classifications
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