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Cat. No.: HY-183909

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EphB1-IN-2

EphB1-IN-2 is a mutant-selective kinase inhibitor of ABL and FGFR4, with an IC₅₀ of 14 nM against ABL^G321C mutant and 163 nM against FGFR4^G556C mutant. EphB1-IN-2 shows selectively over wild-type ABL and FGFR4.

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CAS No.: 2097512-73-5
화학식: C₁₇H₁₅ClN₄O₂
분자량:342.78

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

EphB1-IN-2 Chemical Structure

CAS No.: 2097512-73-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[2]

FGFR4

>10000 nM (IC₅₀)

In Vitro

EphB1-IN-2 (compound 10) shows 37-fold selective inhibition of ABL^G321C over wild-type ABL, with IC₅₀ values of 14 nM and 530 nM, respectively^[2].
EphB1-IN-2 shows greater than 61-fold selective inhibition of FGFR4^G556C over wild-type FGFR4, with an IC₅₀ of 163 nM against FGFR4^G556C and an IC₅₀ greater than 10,000 nM against wild-type FGFR4^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2097512-73-5
분자량 342.78
화학식 C₁₇H₁₅ClN₄O₂
SMILES

O=C(CCl)NC1=CC2=NC=NC(NC3=CC(OC)=CC=C3)=C2C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kung A, et al. A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem Biol. 2017;12(6):1499-1503. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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