ERD-3111
Based on 1 Customer Validation
ERD-3111 is an orally active PROTAC degrader targeting estrogen receptor α (ERα), with a DC50 of 0.5 nM. ERD-3111 induces ERα degradation in breast cancer cells, and triggers tumor regression or complete inhibition of tumor growth in ER-positive breast cancer xenograft models. ERD-3111 can be used in breast cancer-related research.
(Pink: ER ligand (HY-175927); Blue: Cereblon ligand (HY-W248665); Black: linker).
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- Purity: 98.72%
- CAS No.: 2832865-25-3
- 화학식: C45H46F4N8O5
- 분자량:854.89
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보관:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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ERα 0.5 nM (DC50) |
ERD-3111 (compound 44) potently degrades ERα in MCF-7 breast cancer cells, with a DC50 of 0.5 nM and a maximum degradation efficiency of 91%[1].
ERD-3111 (0.1-30 nM) induces dose-dependent ERα degradation in MCF-7 breast cancer cells[1].
ERD-3111 (0.1-100 nM) induces dose-dependent ERα degradation in T47D breast cancer cells[1].
ERD-3111 does not significantly inhibit hERG channels in HEK293 cells at concentrations up to 30 μM, with an IC50 greater than 30 μM; it does not significantly inhibit any tested human CYP enzyme subtypes at concentrations up to 10 μM, with an IC50 value greater than 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Vss | CL | T1/2 | Cmax | AUC | F |
|---|---|---|---|---|---|---|---|---|
| Rat[1] | 1 mg/kg | i.v. | 1.3 L/kg | 7.4 mL/min/kg | 4.0 h | 141.1 ng/mL | 1317 ng·h/mL | / |
| Mice[1] | 1 mg/kg | i.v. | 3.2 L/kg | 5.7 mL/min/kg | 6.4 h | 260 ng/mL | 3366 ng·h/mL | / |
| Dog[1] | 0.5 mg/kg | i.v. | 5.2 L/kg | 11.0 mL/min/kg | 7.9 h | 87 ng/mL | 937 ng·h/mL | / |
| Rat[1] | 3 mg/kg | p.o. | / | / | / | / | / | 20 % |
| Mice[1] | 3 mg/kg | p.o. | / | / | / | / | / | 42 % |
| Dog[1] | 1 mg/kg | p.o. | / | / | / | / | / | 66 % |
ERD-3111 (10 mg/kg; p.o.; once daily; for 3 consecutive days) reduces the protein level of ESR1D538G-mutant ERα in MCF-7 xenograft tumors[1].
ERD-3111 (10-30 mg/kg; p.o.; once daily; for 35 consecutive days) induces sustained tumor regression in wild-type ERα MCF-7 xenografts, and the therapeutic effect is maintained after drug withdrawal[1].
ERD-3111 (10-30 mg/kg; p.o.; once daily; for 28 consecutive days) induces sustained tumor growth inhibition in ESR1Y537S-mutant and ESR1D538G-mutant MCF-7 xenografts, with enhanced efficacy observed even after discontinuation of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CB17 SCID (female, wild-type ERα MCF-7 xenograft and ESR1Y537S mutant MCF-7 xenograft, maintained on 17β-estradiol-supplemented drinking water)[1]
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Dosage:10 mg/kg; 30 mg/kg
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Administration:p.o.; daily; 3 days
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Result:Reduced ERα protein levels after 3-day daily oral administration in female CB17 SCID mice bearing wild-type or ESR1Y537S mutant MCF-7 xenografts.
Achieved dose-dependent depletion of wild-type ERα, reaching maximum reduction of 70% (10 mg/kg) and 78% (30 mg/kg) at 24 h, with detectable compound exposure in plasma and tumor tissues at both doses.
Induced dose-dependent downregulation of ESR1Y537S mutant ERα, achieving 70% suppression at 10 mg/kg and 85% suppression at 30 mg/kg, accompanied by measurable plasma and intratumoral drug concentrations.
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Animal Model:CB17 SCID (female, wild-type ERα MCF-7 xenograft, maintained on 17β-estradiol-supplemented drinking water)[1]
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Dosage:10 mg/kg; 30 mg/kg
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Administration:p.o.; daily; 35 days
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Result:Caused 24% tumor regression at the end of treatment (day 73) at 10 mg/kg.
Caused 42% tumor regression at the end of treatment (day 73) at 30 mg/kg.
Maintained 13% tumor regression three weeks post-treatment (day 93) at 10 mg/kg.
Maintained 42% tumor regression three weeks post-treatment (day 93) at 30 mg/kg.
Exhibited significantly better antitumor activity than 10 mg/kg ARV-471 at day 93 at 10 mg/kg.
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Animal Model:CB17 SCID (female, ESR1D538G mutant MCF-7 xenograft)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 3 days
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Result:Reduced ESR1D538G mutant ERα protein levels in tumors by 68%.
Achieved plasma concentration of 609 ng/mL and tumor concentration of 1052 ng/mL.
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Animal Model:CB17 SCID (female, ESR1Y537S mutant MCF-7 xenograft and ESR1D538G mutant MCF-7 xenograft)[1]
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Dosage:10 mg/kg; 30 mg/kg
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Administration:p.o.; daily; 28 days
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Result:Exhibited dose-dependent antitumor activity after 28-day daily oral dosing in female CB17 SCID mice bearing ESR1-mutant MCF-7 xenografts.
Achieved 72% (10 mg/kg) and 86% (30 mg/kg) tumor growth inhibition at treatment endpoint in ESR1Y537S mutant tumors; antitumor effects persisted until day 82 with 99% and 101% sustained inhibition.
Induced 38% (10 mg/kg) and 51% (30 mg/kg) tumor regression at treatment completion in ESR1D538G mutant tumors, with tumor growth suppression maintained for one week post-treatment cessation.
Chemical Information
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CAS No. 2832865-25-3
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Appearance Solid
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분자량 854.89
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화학식 C45H46F4N8O5
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Color Off-white to light yellow
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SMILES
FC(CN1[C@@H](CC2=C([C@H]1C3=C(C=C(C=C3F)N4CCC5(CC4)CCN(C(CN6CC(C=C(C7=C8)C(N(C7=O)C9CCC(NC9=O)=O)=O)=C8C6)=O)CC5)F)C=CC%10=C2C=NN%10)C)F
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
DMSO : 100 mg/mL (116.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1697 mL | 5.8487 mL | 11.6974 mL | 29.2435 mL |
| 5 mM | 0.2339 mL | 1.1697 mL | 2.3395 mL | 5.8487 mL | |
| 10 mM | 0.1170 mL | 0.5849 mL | 1.1697 mL | 2.9244 mL | |
| 15 mM | 0.0780 mL | 0.3899 mL | 0.7798 mL | 1.9496 mL | |
| 20 mM | 0.0585 mL | 0.2924 mL | 0.5849 mL | 1.4622 mL | |
| 25 mM | 0.0468 mL | 0.2339 mL | 0.4679 mL | 1.1697 mL | |
| 30 mM | 0.0390 mL | 0.1950 mL | 0.3899 mL | 0.9748 mL | |
| 40 mM | 0.0292 mL | 0.1462 mL | 0.2924 mL | 0.7311 mL | |
| 50 mM | 0.0234 mL | 0.1170 mL | 0.2339 mL | 0.5849 mL | |
| 60 mM | 0.0195 mL | 0.0975 mL | 0.1950 mL | 0.4874 mL | |
| 80 mM | 0.0146 mL | 0.0731 mL | 0.1462 mL | 0.3655 mL | |
| 100 mM | 0.0117 mL | 0.0585 mL | 0.1170 mL | 0.2924 mL |
ERD-3111 Related Classifications
HY-149480 Related Classifications
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