FC-11
Based on 1 Customer Validation
FC-11 is a PROTAC FAK degrader (DC90: 1 nM) . FC-11 contains CRBN ligand Pomalidomide (HY-10984), linker and FAK ligand PF562271 (HY-10459).
(Pink: FAK Target protein ligand; Blue: Cereblon ligand (HY-10984); Black: linker).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.95%
- CAS No.: 2271035-37-9
- 화학식: C41H42F3N13O9S
- 분자량:949.91
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보관:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
FC-11 degrades FAK in various cell types, with DC50s being: 310 pM in TM3, 80 pM in PA1, 330 pM in MDA-MB-436, 370 pM in LNCaP, and 40 pM in Ramos[1].
FC-11 (1-10 nM, 8 h) degrades FAK in PA1 cells (compared to DMSO protein degradation) by 99%[1].
FC-11 (1-100 nM, 8 h) induces FAK degradation in PA1 through a CRBN-mediated and proteasome-dependent mechanism[1].
FC-11 (1-3000 nM, 0-9 h) inhibits FAK autophosphorylation in TM3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2271035-37-9
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Appearance Solid
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분자량 949.91
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화학식 C41H42F3N13O9S
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Color Light yellow to yellow
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SMILES
O=C(C1=CN(CCOCCOCCNC2=CC=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(S(=O)(C)=O)C)=N6)C=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
DMSO : 66.67 mg/mL (70.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Gao H, et al. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862. Gao H, Wu Y, Sun Y, Yang Y, Zhou G, Rao Y. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0527 mL | 5.2637 mL | 10.5273 mL | 26.3183 mL |
| 5 mM | 0.2105 mL | 1.0527 mL | 2.1055 mL | 5.2637 mL | |
| 10 mM | 0.1053 mL | 0.5264 mL | 1.0527 mL | 2.6318 mL | |
| 15 mM | 0.0702 mL | 0.3509 mL | 0.7018 mL | 1.7546 mL | |
| 20 mM | 0.0526 mL | 0.2632 mL | 0.5264 mL | 1.3159 mL | |
| 25 mM | 0.0421 mL | 0.2105 mL | 0.4211 mL | 1.0527 mL | |
| 30 mM | 0.0351 mL | 0.1755 mL | 0.3509 mL | 0.8773 mL | |
| 40 mM | 0.0263 mL | 0.1316 mL | 0.2632 mL | 0.6580 mL | |
| 50 mM | 0.0211 mL | 0.1053 mL | 0.2105 mL | 0.5264 mL | |
| 60 mM | 0.0175 mL | 0.0877 mL | 0.1755 mL | 0.4386 mL |
FC-11 Related Classifications
HY-139344 Related Classifications
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