Fumitremorgin B
Fumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL.
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- CAS No.: 12626-17-4
- 화학식: C27H33N3O5
- 분자량:479.57
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보관:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
fungal[3]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
5 μM
Compound: 8; FTM-B
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 27865702] |
| HT-29 | IC50 |
5 μM
Compound: 8; FTM-B
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Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
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[PMID: 27865702] |
| Jurkat | IC50 |
5 μM
Compound: 8; FTM-B
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Cytotoxicity against human Jurkat cells
Cytotoxicity against human Jurkat cells
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[PMID: 27865702] |
| MCF7 | IC50 |
5 μM
Compound: 8; FTM-B
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Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
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[PMID: 27865702] |
| PC-3 | IC50 |
43.36 μM
Compound: 574
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Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38181652] |
| U-937 | IC50 |
14.12 μM
Compound: 574
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Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
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[PMID: 38181652] |
Fumitremorgin B (3 or 4 days) inhibits the proliferation of U937 and PC3 cells, with IC50 of 14.12 and 43.36 μM, respectively[2].
Fumitremorgin B exhibits antifungal activities against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum f. sp. niveum, F. oxysporum f. sp. vasinfectum, and G. saubinettii, with MICs of 6.25-50 μg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 12626-17-4
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Appearance Oil
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분자량 479.57
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화학식 C27H33N3O5
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Color Off-white to light brown
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SMILES
O=C([C@]1(O)[C@@H](O)C2=C([C@H](/C=C(C)\C)N13)N(C/C=C(C)\C)C4=C2C=CC(OC)=C4)N5[C@](CCC5)([H])C3=O
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Structure Classification
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Initial Source
fungus Aspergillus fumigatus
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Li SM, et, al. Genome mining and biosynthesis of fumitremorgin-type alkaloids in ascomycetes. J Antibiot (Tokyo). 2011 Jan;64(1):45-9. [Content Brief]
[2]. Wang Y, et, al. 2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7. Chem Biodivers. 2012 Feb;9(2):385-93. [Content Brief]
[3]. Li XJ, et, al. Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities. J Agric Food Chem. 2012 Apr 4;60(13):3424-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fumitremorgin B Related Classifications
HY-117313 Related Classifications
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