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JUND - JunD proto-oncogene, AP-1 transcription factor subunit Gene

Also Known as AP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3727

About JUND

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,279,694-18,281,622 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 2 paralogues.

Summary

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and Apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

JUND Products (2)

mRNA	Protein	Name
NM_001286968.2	NP_001273897.1	transcription factor JunD isoform deltaJunD
NM_005354.6	NP_005345.3	transcription factor JunD isoform JunD-FL

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9989505	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	1903194	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22327296	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10508860	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA
part of transcription factor AP-1 complex	IDA IDA: Inferred from direct assay	10508860	GOA
part of transcription repressor complex	IPI IPI: Inferred from physical interaction	22327296	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JUND Protein Structure

Jun

bZIP_1

0
100
200
300
347 a.a.

Protein Preferred Names	Protein Names
transcription factor JunD	activator protein 1

JUND Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	JUND	P17535	BATF3	Homo sapiens	Q9NR55	Peptide Array	20102225
Intra	JUND	P17535	ATF2	Homo sapiens	P15336	Peptide Array	20102225
Intra	JUND	P17535	ACTR3	Homo sapiens	P61158	Display Tech	20195357
Intra	JUND	P17535	FOSL2	Homo sapiens	P15408	Peptide Array	20102225
Intra	JUND	P17535	MDM2	Homo sapiens	Q00987	TAP	20195357
Intra	JUND	P17535	ATF3	Homo sapiens	P18847	Peptide Array	20102225
Intra	JUND	P17535	MAPK10	Homo sapiens	P53779	Protein Kinase Assay	22327296
Intra	JUND	P17535	MAPK10	Homo sapiens	P53779	Pull Down	22327296
Intra	JUND	P17535	BATF	Homo sapiens	Q16520	Peptide Array	20102225
Intra	JUND	P17535	ATF7	Homo sapiens	P17544	Peptide Array	20102225
Intra	JUND	P17535	FOS	Homo sapiens	P01100	Display Tech	20195357
Intra	JUND	P17535	FOS	Homo sapiens	P01100	TAP	20195357
Intra	JUND	P17535	FOS	Homo sapiens	P01100	Peptide Array	20102225
Intra	JUND	P17535	MEN1	Homo sapiens	O00255-2	Pull Down	22327296
Cross	JUND	P17535	MDV005	Gallid herpesvirus 2	Q9DGW5	Peptide Array	20102225
Cross	JUND	P17535	HBZ	Human T-cell leukemia virus 1	P0C746	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

JUND Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P82861	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606)	WB, IP	Human, Mouse, Rat
HY-P82861A	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606)(PBS only)	WB, IP	Human, Mouse, Rat
HY-P83342	Phospho-JunD (Ser255) Antibody (YA3087)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Adult T-Cell Leukemia/Lymphoma	Adult T-Cell Leukemia Atll Adult T-Cell Leukaemia Adult T-Cell Leukaemia/Lymphoma Adult T-Cell Lymphoma T Cell Leukemia Lymphoma Adult Leukemia-Lymphoma, Adult T-Cell Leukemia, T-Cell Adult T-Cell Lymphoma/Leukemia
T-Cell Adult Acute Lymphocytic Leukemia	Acute Adult T-Cell Leukemia-Lymphoma Adult Precursor T Lymphoblastic Leukemia Atll T-Cell Adult Acute Lymphoblastic Leukemia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS07060	JUND Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19345	Jund Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179594	HTS10307	Inhibitor	/	Unkown
HY-182050	YL0441	Inhibitor	/	Unkown
HY-W471288	JPC0661	Inhibitor	/	Unkown
HY-RS25836	Jund Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	JUND	RGD	RGD:2945
Felis catus	JUND	VGNC	VGNC:102618
Canis familiaris	JUND	VGNC	VGNC:42199
Mus musculus	JUND	MGD	MGI:96648
Others	JUND	NCBI